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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

GU3_00335

Organism
Oceanimonas sp. (strain GK1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciOSP511062:GI6E-68-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
Ordered Locus Names:GU3_00335Imported
OrganismiOceanimonas sp. (strain GK1)Imported
Taxonomic identifieri511062 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeOceanimonas
ProteomesiUP000007742 Componenti: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H2G1D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTSTIVY TLTDEAPALA TYSLLPIIRT FTDAAGIDVT LSDISLAGRV
60 70 80 90 100
LAAFPERLTD EQRVADGLAE LGKLTQDPHA NIIKLPNISA SVPQLRACIK
110 120 130 140 150
ELQSQGYNVP DFPEEPKTDE DKAIREAYSK ILGSAVNPVL RQGNSDRRAP
160 170 180 190 200
AAVKAFARKY PHSMGAWSKA SRSHADYMNG GDFFSSEQSV TMDKAQTVRI
210 220 230 240 250
EFIGQDGKPQ LKKELALQAG EVLDSMFMSA KALEAFFEQT LQDCKDAGVM
260 270 280 290 300
WSLHVKATMM KVSHPIVFGH AVKVFYKEVF DKYGKLFEEL GVNPNNGMSS
310 320 330 340 350
VLEKIKTLPQ STQEEIEQAI HDCYEHRPEM AMVDSVKGIT NLHVPSDVIV
360 370 380 390 400
DASMPAMIRN SGQMWGRDGK LKDTKAVMPE STYARIYQEV INFCKTNGAF
410 420 430 440 450
DPRTMGSVSN VGLMAMKAEE YGSHDKTFEM TENGTMRVVN EAGEVLMQHE
460 470 480 490 500
VEKGDIWRAC QTKDAAIRDW VKLAVNRARN SATPAVFWLD DERAHDNELR
510 520 530 540 550
KKVNTYLQEH DLTGLDIHIM SYNEAIRFSM ERMKRGKDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPIMEL GTSAKMLSIV PMLAGGGMYE TGAGGSAPKH VQQLMEENHL
610 620 630 640 650
RWDSLGEFLA LAVSLEELGI KEGNDRAKLL AKCLDKATEL LLDNGKSPSR
660 670 680 690 700
RAGELDNRGS HFYLALYWAQ ELAAQTEDEA LAAHFAPLAK ALADNEAKIV
710 720 730 740
AELNAVQGKS AGVHGYYHAS PAELEQVMRP SATLNQTLAQ LNG
Length:743
Mass (Da):82,090
Last modified:March 20, 2012 - v1
Checksum:i91323AD118B672FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003171 Genomic DNA. Translation: AEX99823.1.
RefSeqiWP_014290560.1. NC_016745.1.
YP_005090574.1. NC_016745.1.

Genome annotation databases

EnsemblBacteriaiAEX99823; AEX99823; GU3_00335.
KEGGioce:GU3_00335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003171 Genomic DNA. Translation: AEX99823.1.
RefSeqiWP_014290560.1. NC_016745.1.
YP_005090574.1. NC_016745.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEX99823; AEX99823; GU3_00335.
KEGGioce:GU3_00335.

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Enzyme and pathway databases

BioCyciOSP511062:GI6E-68-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Oceanimonas sp. GK1, a halotolerant bacterium from Gavkhouni Wetland in Iran."
    Parsa Yeganeh L., Azarbaijani R., Sarikhan S., Mousavi H., Ramezani M., Amoozegar M.A., Shahzadeh Fazeli A., Salekdeh G.H.
    J. Bacteriol. 194:2123-2124(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GK1Imported.

Entry informationi

Entry nameiH2G1D1_OCESG
AccessioniPrimary (citable) accession number: H2G1D1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2012
Last sequence update: March 20, 2012
Last modified: March 31, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.