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H2FR23 (H2FR23_CORPS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetate kinase HAMAP-Rule MF_00020
EC=2.7.2.1 HAMAP-Rule MF_00020
Alternative name(s):
Acetokinase HAMAP-Rule MF_00020
Gene names
Name:ackA HAMAP-Rule MF_00020 EMBL AEX40333.1
ORF Names:Cp3995_1883 EMBL AEX40333.1
OrganismCorynebacterium pseudotuberculosis 3/99-5 EMBL AEX40333.1
Taxonomic identifier1087452 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction By similarity. HAMAP-Rule MF_00020

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP-Rule MF_00020

Cofactor

Mg2+. Can also accept Mn2+ By similarity. HAMAP-Rule MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP-Rule MF_00020

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00020

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00020 SAAS SAAS023865.

Sequence similarities

Belongs to the acetokinase family. RuleBase RU003835

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding209 – 2135ATP By similarity HAMAP-Rule MF_00020
Nucleotide binding283 – 2853ATP By similarity HAMAP-Rule MF_00020
Nucleotide binding331 – 3355ATP By similarity HAMAP-Rule MF_00020

Sites

Active site1491Proton donor/acceptor By similarity HAMAP-Rule MF_00020
Metal binding81Magnesium By similarity HAMAP-Rule MF_00020
Metal binding3851Magnesium By similarity HAMAP-Rule MF_00020
Binding site151ATP By similarity HAMAP-Rule MF_00020
Binding site921Substrate By similarity HAMAP-Rule MF_00020
Site1811Transition state stabilizer By similarity HAMAP-Rule MF_00020
Site2421Transition state stabilizer By similarity HAMAP-Rule MF_00020

Sequences

Sequence LengthMass (Da)Tools
H2FR23 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 3A32ECB8502BE121

FASTA40042,855
        10         20         30         40         50         60 
MALVLVLNSG SSSIKFQLVD PTQHATDAPF ASGLVEQIGE PKGKITLKHG GEKYVVEAPI 

        70         80         90        100        110        120 
ADHTAGLDLA FKLMGEHGCG PKDVELEAVG HRVVHGGQVF SQPELITDEV VEAIRGLIPL 

       130        140        150        160        170        180 
APLHNPANIS GIEVARTLLP ELPHVAVFDT GFFYSMPPAS ALYAIESETA TKNGVRRYGF 

       190        200        210        220        230        240 
HGTSHEYISQ QVPKLLGKDP EDVNQITLHL GNGASAAAIR QGNPIDTSMG MTPLAGLAMG 

       250        260        270        280        290        300 
TRSGDIDPGI IFHLYRTAGM SIDEIDDLLN KRSGVKGISG VNDFRELHQL IAEGNEDARL 

       310        320        330        340        350        360 
AYKVYIQQLR RFIGSYMISL GRIDAITFTA GVGENDDAVR ADALADLENF GIKIDLEANA 

       370        380        390        400 
VRADGAREIS TPDSTIKVFV VPTNEELAIA RYAKTIAESV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003152 Genomic DNA. Translation: AEX40333.1.
RefSeqYP_005123982.1. NC_016781.1.

3D structure databases

ProteinModelPortalH2FR23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEX40333; AEX40333; Cp3995_1883.
GeneID11674761.
KEGGcpl:Cp3995_1883.

Phylogenomic databases

KOK00925.

Enzyme and pathway databases

UniPathwayUPA00340; UER00458.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERPTHR21060. PTHR21060. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. ackA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2FR23_CORPS
AccessionPrimary (citable) accession number: H2FR23
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 1, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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