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Protein

Cellular tumor antigen p53

Gene

TP53

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

ApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:TP53Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiH2EHT1.
PRIDEiH2EHT1.

PTM databases

iPTMnetiH2EHT1.

Expressioni

Gene expression databases

BgeeiH2EHT1.
ExpressionAtlasiH2EHT1. baseline and differential.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000269305.

Chemistry

BindingDBiH2EHT1.

Structurei

3D structure databases

ProteinModelPortaliH2EHT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 249194P53InterPro annotationAdd
BLAST
Domaini280 – 31839P53_tetramerInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2EHT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLMLSPDD IEQWFTEDPG PDEAPRMPEA APPVAPAPAA PTPAAPAPAP
60 70 80 90 100
SWPLSSSVPS QKTYQGSYGF RLGFLHSGTA KSVTCTYSPA LNKMFCQLAK
110 120 130 140 150
TCPVQLWVDS TPPPGTRVRA MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA
160 170 180 190 200
PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP YEPPEVGSDC TTIHYNYMCN
210 220 230 240 250
SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG RDRRTEEENL
260 270 280 290 300
RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE
310 320 330 340 350
MFRELNEALE LKDAQAGKEP GGSRAHSSHL KSKKGQSTSR HKKLMFKTEG

PDSD
Length:354
Mass (Da):39,320
Last modified:March 21, 2012 - v1
Checksum:i6F12310423325770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN900492 mRNA. Translation: AEX20383.1.
RefSeqiNP_001119590.1. NM_001126118.1.
NP_001263689.1. NM_001276760.1.
NP_001263690.1. NM_001276761.1.
UniGeneiHs.437460.
Hs.740601.

Genome annotation databases

GeneIDi7157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN900492 mRNA. Translation: AEX20383.1.
RefSeqiNP_001119590.1. NM_001126118.1.
NP_001263689.1. NM_001276760.1.
NP_001263690.1. NM_001276761.1.
UniGeneiHs.437460.
Hs.740601.

3D structure databases

ProteinModelPortaliH2EHT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269305.

Chemistry

BindingDBiH2EHT1.

PTM databases

iPTMnetiH2EHT1.

Proteomic databases

PaxDbiH2EHT1.
PRIDEiH2EHT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7157.

Organism-specific databases

CTDi7157.

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.

Miscellaneous databases

ChiTaRSiTP53. human.
GenomeRNAii7157.
NextBioi28006.

Gene expression databases

BgeeiH2EHT1.
ExpressionAtlasiH2EHT1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms."
    Marcel V., Tran P.L., Sagne C., Martel-Planche G., Vaslin L., Teulade-Fichou M.P., Hall J., Mergny J.L., Hainaut P., Van Dyck E.
    Carcinogenesis 32:271-278(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiH2EHT1_HUMAN
AccessioniPrimary (citable) accession number: H2EHT1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: March 16, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.