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Protein

Sterol 24-C-methyltransferase

Gene

KAFR0C05410

Organism
Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.UniRule annotation

Pathwayi: ergosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ergosterol from zymosterol.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Sterol 24-C-methyltransferase (KAFR0C05410)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway ergosterol biosynthesis, which is itself part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ergosterol from zymosterol, the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferaseUniRule annotation (EC:2.1.1.41UniRule annotation)
Alternative name(s):
Delta(24)-sterol C-methyltransferaseUniRule annotation
Gene namesi
Name:KAFR0C05410Imported
ORF Names:KAFR_0C05410Imported
OrganismiKazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)Imported
Taxonomic identifieri1071382 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania
Proteomesi
  • UP000005220 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliH2AT32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 371SAM_MT_ERG6_SMTInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiH2AT32
KOiK00559
OrthoDBiEOG092C2LI4

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit

Sequencei

Sequence statusi: Complete.

H2AT32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEENNQELR RRQAEFSKKL HGEDSATKTG LKAFLSKDKS AQKEAVSKYL
60 70 80 90 100
KHWDGKVDTE AENARLEDYN ESTHAYYNVV TDFYEYGWGS SFHFCRFSKG
110 120 130 140 150
ENFNAAMARH EHYLAYMADI KANDLVLDVG CGVGGPAREI VKFTDCNVIG
160 170 180 190 200
LNNNDYQIEK AKWYAKKTGL QDKMDFVKGD FMNMDFDENT FDKVYAIEAT
210 220 230 240 250
CHAPDLAKCY SEIYKVLKPG GRFAVYEWVM TENYDENNEA HRKVAYEIEL
260 270 280 290 300
GDGIPKMFKV EVAKDALVKA GFNVLVDKDL ADNDDPVPWY YPLTGDWKYV
310 320 330 340 350
QSLGDLATFF RTSYLGRKFT SSMVSLMEKI GVAPEGSCKV TEALEQAAVG
360 370
LVAGGKSKLF TPMMLFVAEK PLQTDTDQ
Length:378
Mass (Da):42,805
Last modified:March 21, 2012 - v1
Checksum:iAE8C3486242516A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE650823 Genomic DNA Translation: CCF57532.1
RefSeqiXP_003956667.1, XM_003956618.1

Genome annotation databases

EnsemblFungiiCCF57532; CCF57532; KAFR_0C05410
GeneIDi13885450
KEGGikaf:KAFR_0C05410

Similar proteinsi

Entry informationi

Entry nameiH2AT32_KAZAF
AccessioniPrimary (citable) accession number: H2AT32
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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