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Protein

Glutamate decarboxylase

Gene

KAFR0B03640

Organism
Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:KAFR0B03640Imported
ORF Names:KAFR_0B03640Imported
OrganismiKazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)Imported
Taxonomic identifieri1071382 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania
ProteomesiUP000005220: Chromosome 2

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

InParanoidiH2AQL1.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

H2AQL1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLHRHSAKHR NPRTVFTHKK SDLPPESKLL SYQEQELEKG KLSGVESVDD
60 70 80 90 100
ARPTLANKYK IPKQGIEEKY AYQLVHNELT LDGNPHLNLA SFVNTYSTDE
110 120 130 140 150
AKRLITENLN KNLADNDEYP QLIEITQRCI SILSQLWHCD ENMEPMGCST
160 170 180 190 200
TGSSEAIMLG GLAMKKNWVK KMEKAGKPID KPNIVMSCAC QVALEKFARY
210 220 230 240 250
FDVECRLVPV SAKSHHMLDP SLLHEYVDEN TIGLFVIMGT TYTGHLEDVE
260 270 280 290 300
DVSNTLTKLE KEHPEWSNTQ IPIHVDGASG GFIVPFAFEN SHMKEFGLER
310 320 330 340 350
WAFNNPRVVS INTSSHKFGL TTPGLGWVLW KDEAYLPQEL RFRLKYLGGV
360 370 380 390 400
EETFGLNFSR PGFQVVHQYF NFISKGAAGY RETFRRSLFV ARVFSHGLLT
410 420 430 440 450
SNKLKGCFDI VSSIHEKITD SSTPKGVNEY WESPSLFKPG VPLVAFKLTK
460 470 480 490 500
EFQAEYSEIP QVLISSMLRA RGWIIPNYPL PKSTDESDKD EVLRVVFRHE
510 520 530 540 550
MKLDLAQLLL FDIEMVMQRL VNSYRRVCMH VDKKLTESDE SKGLRRSFIY
560 570 580 590
DMLLTLASPE GEEISEGDLN AKEDELNKKH KKKQEIRERT SRNYRGTC
Length:598
Mass (Da):68,409
Last modified:March 21, 2012 - v1
Checksum:i41BB2166061BD43A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE650822 Genomic DNA. Translation: CCF56661.1.
RefSeqiXP_003955796.1. XM_003955747.1.

Genome annotation databases

GeneIDi13883121.
KEGGikaf:KAFR_0B03640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE650822 Genomic DNA. Translation: CCF56661.1.
RefSeqiXP_003955796.1. XM_003955747.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13883121.
KEGGikaf:KAFR_0B03640.

Phylogenomic databases

InParanoidiH2AQL1.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents."
    Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276Imported.

Entry informationi

Entry nameiH2AQL1_KAZAF
AccessioniPrimary (citable) accession number: H2AQL1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: February 4, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.