Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-structural protein NS-S

Gene

N

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in the inhibition of the host immune response by intefering with the production of interferon in infected cells.1 Publication

GO - Biological processi

  1. viral process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:N
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9191Non-structural protein NS-SPRO_0000422474Add
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 374Poly-Ser

Sequence similaritiesi

Family and domain databases

InterProiIPR000797. Bunya_NSs.
[Graphical view]
PfamiPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform NSS (identifier: H2AM14-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYHNGMQLHL TRRSGMWHLL VSMGNNSTSV LLESSSSTRR RPRWSYIRRH
60 70 80 90
NQVSILLLVG SNLQWLITIF PNMSQILCQT MPLHFTGCQD I

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:91
Mass (Da):10,598
Last modified:March 21, 2012 - v1
Checksum:iB2A97F19CD8EBFDB
GO
Isoform N (identifier: H2AM13-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry H2AM13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:233
Mass (Da):26,181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853181 Viral cRNA. Translation: AGC84163.1.
KC139379 Viral cRNA. Translation: AGD94637.1.
KC139380 Viral cRNA. Translation: AGD94639.1.
KC139381 Viral cRNA. Translation: AGD94641.1.
HE649914 Genomic RNA. Translation: CCF55032.1.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853181 Viral cRNA. Translation: AGC84163.1.
KC139379 Viral cRNA. Translation: AGD94637.1.
KC139380 Viral cRNA. Translation: AGD94639.1.
KC139381 Viral cRNA. Translation: AGD94641.1.
HE649914 Genomic RNA. Translation: CCF55032.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000797. Bunya_NSs.
[Graphical view]
PfamiPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: BH80/11-4.
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: BH80/11-4.
  3. "In vivo and in vitro identification of a hypervariable region in Schmallenberg virus."
    Coupeau D., Claine F., Wiggers L., Kirschvink N., Muylkens B.
    J. Gen. Virol. 94:1168-1174(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Na2.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], FUNCTION.
    Strain: Germany.

Entry informationi

Entry nameiNSS_SBVBH
AccessioniPrimary (citable) accession number: H2AM14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 1, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.