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H2AM14 (NSS_SBVBH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein NS-S
Gene names
Name:N
OrganismBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifier1318464 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in the inhibition of the host immune response by intefering with the production of interferon in infected cells. Ref.4

Sequence similarities

Belongs to the orthobunyavirus NS-S protein family.

Ontologies

Keywords
   Coding sequence diversityAlternative initiation
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform NSS (identifier: H2AM14-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.
Isoform N (identifier: H2AM13-1)

The sequence of this isoform can be found in the external entry H2AM13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9191Non-structural protein NS-S
PRO_0000422474

Regions

Compositional bias34 – 374Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Isoform NSS [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: B2A97F19CD8EBFDB

FASTA9110,598
        10         20         30         40         50         60 
MYHNGMQLHL TRRSGMWHLL VSMGNNSTSV LLESSSSTRR RPRWSYIRRH NQVSILLLVG 

        70         80         90 
SNLQWLITIF PNMSQILCQT MPLHFTGCQD I 

« Hide

Isoform N [UniParc].

See H2AM13.

References

[1]"Novel orthobunyavirus in cattle, europe, 2011."
Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H., Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A., Mettenleiter T.C., Beer M.
Emerg. Infect. Dis. 18:469-472(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: BH80/11-4.
[2]Hoeper D.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: BH80/11-4.
[3]"In vivo and in vitro identification of a hypervariable region in Schmallenberg virus."
Coupeau D., Claine F., Wiggers L., Kirschvink N., Muylkens B.
J. Gen. Virol. 94:1168-1174(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Na2.
[4]"Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host."
Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M., McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M., Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.
PLoS Pathog. 9:E1003133-E1003133(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], FUNCTION.
Strain: Germany.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JX853181 Viral cRNA. Translation: AGC84163.1.
KC139379 Viral cRNA. Translation: AGD94637.1.
KC139380 Viral cRNA. Translation: AGD94639.1.
KC139381 Viral cRNA. Translation: AGD94641.1.
HE649914 Genomic RNA. Translation: CCF55032.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000797. Bunya_NSs.
[Graphical view]
PfamPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSS_SBVBH
AccessionPrimary (citable) accession number: H2AM14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 16, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families