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H2AM14

- NSS_SBVBH

UniProt

H2AM14 - NSS_SBVBH

Protein

Non-structural protein NS-S

Gene

N

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Plays a role in the inhibition of the host immune response by intefering with the production of interferon in infected cells.1 Publication

    GO - Biological processi

    1. viral process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:N
    OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
    Taxonomic identifieri1318464 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9191Non-structural protein NS-SPRO_0000422474Add
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 374Poly-Ser

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000797. Bunya_NSs.
    [Graphical view]
    PfamiPF01104. Bunya_NS-S. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform NSS (identifier: H2AM14-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYHNGMQLHL TRRSGMWHLL VSMGNNSTSV LLESSSSTRR RPRWSYIRRH   50
    NQVSILLLVG SNLQWLITIF PNMSQILCQT MPLHFTGCQD I 91

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:91
    Mass (Da):10,598
    Last modified:March 21, 2012 - v1
    Checksum:iB2A97F19CD8EBFDB
    GO
    Isoform N (identifier: H2AM13-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry H2AM13.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:233
    Mass (Da):26,181
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853181 Viral cRNA. Translation: AGC84163.1.
    KC139379 Viral cRNA. Translation: AGD94637.1.
    KC139380 Viral cRNA. Translation: AGD94639.1.
    KC139381 Viral cRNA. Translation: AGD94641.1.
    HE649914 Genomic RNA. Translation: CCF55032.1.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853181 Viral cRNA. Translation: AGC84163.1 .
    KC139379 Viral cRNA. Translation: AGD94637.1 .
    KC139380 Viral cRNA. Translation: AGD94639.1 .
    KC139381 Viral cRNA. Translation: AGD94641.1 .
    HE649914 Genomic RNA. Translation: CCF55032.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000797. Bunya_NSs.
    [Graphical view ]
    Pfami PF01104. Bunya_NS-S. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: BH80/11-4.
    2. Hoeper D.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: BH80/11-4.
    3. "In vivo and in vitro identification of a hypervariable region in Schmallenberg virus."
      Coupeau D., Claine F., Wiggers L., Kirschvink N., Muylkens B.
      J. Gen. Virol. 94:1168-1174(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Na2.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], FUNCTION.
      Strain: Germany.

    Entry informationi

    Entry nameiNSS_SBVBH
    AccessioniPrimary (citable) accession number: H2AM14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2013
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3