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H2AM13

- NCAP_SBVBH

UniProt

H2AM13 - NCAP_SBVBH

Protein

Nucleoprotein

Gene

N

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
    Taxonomic identifieri1318464 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

    Subcellular locationi

    Virion
    Note: Internal protein of virus particle.By similarity

    GO - Cellular componenti

    1. ribonucleoprotein complex Source: UniProtKB-KW
    2. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233NucleoproteinPRO_0000422475Add
    BLAST

    Interactioni

    Subunit structurei

    omomultimerizes to form the nucleocapsid. Binds to viral genomic RNA By similarity.By similarity

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 3112
    Helixi32 – 343
    Helixi37 – 459
    Helixi47 – 5610
    Beta strandi59 – 668
    Beta strandi69 – 746
    Helixi79 – 813
    Helixi93 – 11018
    Helixi112 – 12110
    Turni125 – 1273
    Helixi128 – 1303
    Helixi134 – 1363
    Helixi138 – 1425
    Helixi148 – 1514
    Turni152 – 1576
    Helixi158 – 16811
    Helixi177 – 1815
    Beta strandi185 – 1873
    Helixi190 – 1967
    Helixi198 – 20912
    Helixi222 – 2254
    Turni226 – 2283

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZL9X-ray2.75A/B/C/D1-233[»]
    4IDUX-ray3.08A/B/C/D1-233[»]
    4IDXX-ray3.21A/B/C1-233[»]
    4JNGX-ray2.12A/B/C/D1-233[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001784. Bunya_nucleocap.
    [Graphical view]
    PfamiPF00952. Bunya_nucleocap. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
    ProDomiPD001909. Bunya_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform N (identifier: H2AM13-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSQFIFEDV PQRNAATFNP EVGYVAFIGK YGQQLNFGVA RVFFLNQKKA    50
    KMVLHKTAQP SVDLTFGGVK FTVVNNHFPQ YVSNPVPDNA ITLHRMSGYL 100
    ARWIADTCKA SVLKLAEASA QIVMPLAEVK GCTWADGYTM YLGFAPGAEM 150
    FLDAFDFYPL VIEMHRVLKD NMDVNFMKKV LRQRYGTMTA EEWMTQKITE 200
    IKAAFNSVGQ LAWAKSGFSP AARTFLQQFG INI 233
    Length:233
    Mass (Da):26,181
    Last modified:March 21, 2012 - v1
    Checksum:i78093278B94464E9
    GO
    Isoform NSS (identifier: H2AM14-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry H2AM14.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:91
    Mass (Da):10,598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853181 Viral cRNA. Translation: AGC84162.1.
    KC108842 Viral cRNA. Translation: AGC93537.1.
    KC108848 Viral cRNA. Translation: AGC93540.1.
    KC108852 Viral cRNA. Translation: AGC93542.1.
    KC108856 Viral cRNA. Translation: AGC93544.1.
    KC108866 Viral cRNA. Translation: AGC93549.1.
    KC108874 Viral cRNA. Translation: AGC93553.1.
    KC108878 Viral cRNA. Translation: AGC93555.1.
    KC108880 Viral cRNA. Translation: AGC93556.1.
    KC108882 Viral cRNA. Translation: AGC93557.1.
    KC108884 Viral cRNA. Translation: AGC93558.1.
    KC108886 Viral cRNA. Translation: AGC93559.1.
    HE649914 Genomic RNA. Translation: CCF55031.1.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853181 Viral cRNA. Translation: AGC84162.1 .
    KC108842 Viral cRNA. Translation: AGC93537.1 .
    KC108848 Viral cRNA. Translation: AGC93540.1 .
    KC108852 Viral cRNA. Translation: AGC93542.1 .
    KC108856 Viral cRNA. Translation: AGC93544.1 .
    KC108866 Viral cRNA. Translation: AGC93549.1 .
    KC108874 Viral cRNA. Translation: AGC93553.1 .
    KC108878 Viral cRNA. Translation: AGC93555.1 .
    KC108880 Viral cRNA. Translation: AGC93556.1 .
    KC108882 Viral cRNA. Translation: AGC93557.1 .
    KC108884 Viral cRNA. Translation: AGC93558.1 .
    KC108886 Viral cRNA. Translation: AGC93559.1 .
    HE649914 Genomic RNA. Translation: CCF55031.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZL9 X-ray 2.75 A/B/C/D 1-233 [» ]
    4IDU X-ray 3.08 A/B/C/D 1-233 [» ]
    4IDX X-ray 3.21 A/B/C 1-233 [» ]
    4JNG X-ray 2.12 A/B/C/D 1-233 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001784. Bunya_nucleocap.
    [Graphical view ]
    Pfami PF00952. Bunya_nucleocap. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
    ProDomi PD001909. Bunya_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Hoeper D.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Hot spot of mutation in the Schmallenberg virus M-segment detected in German field isolates."
      Fischer M., Hoffmann B., Goller K.V., Wernike K., Beer M.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: BH02/12-1, BH148/12-9, BH200/12-2, BH248/12-1, BH336/12-1, BH336/12-3, BH37/12-2, BH619/12-1, BH635/12-2, BH652/12-1 and BH77/12-1.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Germany.

    Entry informationi

    Entry nameiNCAP_SBVBH
    AccessioniPrimary (citable) accession number: H2AM13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2013
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3