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H2AM13

- NCAP_SBVBH

UniProt

H2AM13 - NCAP_SBVBH

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Protein
Nucleoprotein
Gene
N
Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Subcellular locationi

Virion
Note: Internal protein of virus particle By similarity.

GO - Cellular componenti

  1. ribonucleoprotein complex Source: UniProtKB-KW
  2. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Nucleoprotein
PRO_0000422475Add
BLAST

Interactioni

Subunit structurei

omomultimerizes to form the nucleocapsid. Binds to viral genomic RNA By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 3112
Helixi32 – 343
Helixi37 – 459
Helixi47 – 5610
Beta strandi59 – 668
Beta strandi69 – 746
Helixi79 – 813
Helixi93 – 11018
Helixi112 – 12110
Turni125 – 1273
Helixi128 – 1303
Helixi134 – 1363
Helixi138 – 1425
Helixi148 – 1514
Turni152 – 1576
Helixi158 – 16811
Helixi177 – 1815
Beta strandi185 – 1873
Helixi190 – 1967
Helixi198 – 20912
Helixi222 – 2254
Turni226 – 2283

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZL9X-ray2.75A/B/C/D1-233[»]
4IDUX-ray3.08A/B/C/D1-233[»]
4IDXX-ray3.21A/B/C1-233[»]
4JNGX-ray2.12A/B/C/D1-233[»]

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform N (identifier: H2AM13-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSQFIFEDV PQRNAATFNP EVGYVAFIGK YGQQLNFGVA RVFFLNQKKA    50
KMVLHKTAQP SVDLTFGGVK FTVVNNHFPQ YVSNPVPDNA ITLHRMSGYL 100
ARWIADTCKA SVLKLAEASA QIVMPLAEVK GCTWADGYTM YLGFAPGAEM 150
FLDAFDFYPL VIEMHRVLKD NMDVNFMKKV LRQRYGTMTA EEWMTQKITE 200
IKAAFNSVGQ LAWAKSGFSP AARTFLQQFG INI 233
Length:233
Mass (Da):26,181
Last modified:March 21, 2012 - v1
Checksum:i78093278B94464E9
GO
Isoform NSS (identifier: H2AM14-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry H2AM14.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:91
Mass (Da):10,598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853181 Viral cRNA. Translation: AGC84162.1.
KC108842 Viral cRNA. Translation: AGC93537.1.
KC108848 Viral cRNA. Translation: AGC93540.1.
KC108852 Viral cRNA. Translation: AGC93542.1.
KC108856 Viral cRNA. Translation: AGC93544.1.
KC108866 Viral cRNA. Translation: AGC93549.1.
KC108874 Viral cRNA. Translation: AGC93553.1.
KC108878 Viral cRNA. Translation: AGC93555.1.
KC108880 Viral cRNA. Translation: AGC93556.1.
KC108882 Viral cRNA. Translation: AGC93557.1.
KC108884 Viral cRNA. Translation: AGC93558.1.
KC108886 Viral cRNA. Translation: AGC93559.1.
HE649914 Genomic RNA. Translation: CCF55031.1.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853181 Viral cRNA. Translation: AGC84162.1 .
KC108842 Viral cRNA. Translation: AGC93537.1 .
KC108848 Viral cRNA. Translation: AGC93540.1 .
KC108852 Viral cRNA. Translation: AGC93542.1 .
KC108856 Viral cRNA. Translation: AGC93544.1 .
KC108866 Viral cRNA. Translation: AGC93549.1 .
KC108874 Viral cRNA. Translation: AGC93553.1 .
KC108878 Viral cRNA. Translation: AGC93555.1 .
KC108880 Viral cRNA. Translation: AGC93556.1 .
KC108882 Viral cRNA. Translation: AGC93557.1 .
KC108884 Viral cRNA. Translation: AGC93558.1 .
KC108886 Viral cRNA. Translation: AGC93559.1 .
HE649914 Genomic RNA. Translation: CCF55031.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZL9 X-ray 2.75 A/B/C/D 1-233 [» ]
4IDU X-ray 3.08 A/B/C/D 1-233 [» ]
4IDX X-ray 3.21 A/B/C 1-233 [» ]
4JNG X-ray 2.12 A/B/C/D 1-233 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001784. Bunya_nucleocap.
[Graphical view ]
Pfami PF00952. Bunya_nucleocap. 1 hit.
[Graphical view ]
PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
ProDomi PD001909. Bunya_nucleocap. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Hot spot of mutation in the Schmallenberg virus M-segment detected in German field isolates."
    Fischer M., Hoffmann B., Goller K.V., Wernike K., Beer M.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: BH02/12-1, BH148/12-9, BH200/12-2, BH248/12-1, BH336/12-1, BH336/12-3, BH37/12-2, BH619/12-1, BH635/12-2, BH652/12-1 and BH77/12-1.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Germany.

Entry informationi

Entry nameiNCAP_SBVBH
AccessioniPrimary (citable) accession number: H2AM13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: January 22, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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