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H2AM13 (NCAP_SBVBH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:N
OrganismBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifier1318464 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) By similarity.

Subunit structure

omomultimerizes to form the nucleocapsid. Binds to viral genomic RNA By similarity.

Subcellular location

Virion. Note: Internal protein of virus particle By similarity.

Sequence similarities

Belongs to the orthobunyavirus nucleocapsid protein family.

Ontologies

Keywords
   Cellular componentVirion
   Coding sequence diversityAlternative initiation
   LigandRNA-binding
Viral nucleoprotein
   Molecular functionRibonucleoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Cellular_componentribonucleoprotein complex

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform N (identifier: H2AM13-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform NSS (identifier: H2AM14-1)

The sequence of this isoform can be found in the external entry H2AM14.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Nucleoprotein
PRO_0000422475

Secondary structure

........................................ 233
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform N [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 78093278B94464E9

FASTA23326,181
        10         20         30         40         50         60 
MSSQFIFEDV PQRNAATFNP EVGYVAFIGK YGQQLNFGVA RVFFLNQKKA KMVLHKTAQP 

        70         80         90        100        110        120 
SVDLTFGGVK FTVVNNHFPQ YVSNPVPDNA ITLHRMSGYL ARWIADTCKA SVLKLAEASA 

       130        140        150        160        170        180 
QIVMPLAEVK GCTWADGYTM YLGFAPGAEM FLDAFDFYPL VIEMHRVLKD NMDVNFMKKV 

       190        200        210        220        230 
LRQRYGTMTA EEWMTQKITE IKAAFNSVGQ LAWAKSGFSP AARTFLQQFG INI 

« Hide

Isoform NSS [UniParc].

See H2AM14.

References

[1]"Novel orthobunyavirus in cattle, europe, 2011."
Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H., Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A., Mettenleiter T.C., Beer M.
Emerg. Infect. Dis. 18:469-472(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Hoeper D.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Hot spot of mutation in the Schmallenberg virus M-segment detected in German field isolates."
Fischer M., Hoffmann B., Goller K.V., Wernike K., Beer M.
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: BH02/12-1, BH148/12-9, BH200/12-2, BH248/12-1, BH336/12-1, BH336/12-3, BH37/12-2, BH619/12-1, BH635/12-2, BH652/12-1 and BH77/12-1.
[4]"Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host."
Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M., McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M., Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.
PLoS Pathog. 9:E1003133-E1003133(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Germany.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JX853181 Viral cRNA. Translation: AGC84162.1.
KC108842 Viral cRNA. Translation: AGC93537.1.
KC108848 Viral cRNA. Translation: AGC93540.1.
KC108852 Viral cRNA. Translation: AGC93542.1.
KC108856 Viral cRNA. Translation: AGC93544.1.
KC108866 Viral cRNA. Translation: AGC93549.1.
KC108874 Viral cRNA. Translation: AGC93553.1.
KC108878 Viral cRNA. Translation: AGC93555.1.
KC108880 Viral cRNA. Translation: AGC93556.1.
KC108882 Viral cRNA. Translation: AGC93557.1.
KC108884 Viral cRNA. Translation: AGC93558.1.
KC108886 Viral cRNA. Translation: AGC93559.1.
HE649914 Genomic RNA. Translation: CCF55031.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZL9X-ray2.75A/B/C/D1-233[»]
4IDUX-ray3.08A/B/C/D1-233[»]
4IDXX-ray3.21A/B/C1-233[»]
4JNGX-ray2.12A/B/C/D1-233[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001784. Bunya_nucleocap.
[Graphical view]
PfamPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFPIRSF003947. N_OrthobunV. 1 hit.
ProDomPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNCAP_SBVBH
AccessionPrimary (citable) accession number: H2AM13
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: January 22, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references