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H2AM12

- GP_SBVBH

UniProt

H2AM12 - GP_SBVBH

Protein

Envelope glycoprotein

Gene

GP

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. modulation by virus of host morphology or physiology Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
    Taxonomic identifieri1318464 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.By similarity
    Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
    Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 14031386Envelope glycoproteinPRO_0000422470Add
    BLAST
    Chaini18 – 308291Glycoprotein G2PRO_0000422471Add
    BLAST
    Chaini309 – 466158Non-structural protein NSmPRO_0000422472Add
    BLAST
    Chaini467 – 1403937Glycoprotein G1PRO_0000422473Add
    BLAST

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini231 – 31484CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini336 – 36126LumenalSequence AnalysisAdd
    BLAST
    Topological domaini383 – 44866CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini470 – 1361892LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1383 – 140321CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1362 – 138221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    [Graphical view]
    PfamiPF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    H2AM12-1 [UniParc]FASTAAdd to Basket

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    MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV     50
    KDDISIIKSN AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI 100
    LDIDNTGTLI PKMHTCRVEC EIALNKDTGE VILNSYRINH YRISGTMHVS 150
    GWFKNKIEIP LENTCESIEV TCGLKTLNFH ACFHTHKSCT RYFKGSILPE 200
    LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP IFYPFVKLYA 250
    YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG 300
    YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI 350
    TCKRELANIK SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM 400
    VHERRGLKIM DNFTNKCLSC VCAENKGLTI HRASEKCLFK FESSYNRTGL 450
    IIFMLLLVPT IVMTQETSIN CKNIQSTQLT IEHLSKCMAF YQNKTSSPVV 500
    INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV YYEYIKSQLC 550
    PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS 600
    TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK 650
    DYQALRHIQG KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS 700
    LIKGAHRNLD QKDPGPTPIL VCKSPQKVVC YSPRGVTHPG DYISCKSKMY 750
    KWPSLGVYKH NRDQQQACSS DTHCLEMFEP AERTITTKIC KVSDMTYSES 800
    PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK AHSKTNDITL 850
    YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ 900
    SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA 950
    INGLSAGINI AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH 1000
    EEVCTGKCPS PIPHQDGWVT FSKERSSNWG CEEWGCLAIN DGCLYGSCQD 1050
    IIRPEYKIYK KSSIEQKDVE VCITMAHESF CSTVDVLQPL ISDRIQLDIQ 1100
    TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS EGIIGSGTPK 1150
    FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS 1200
    SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST 1250
    NTIGSCSIKS NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA 1300
    YTKPSISKNQ PKIVLNSLDE TSYIEQHDKK CSTWLCRVYK EGISVIFQPL 1350
    FGNLSFYWRL TIYIIISLIM LILFLYILIP LCKRLKGLLE YNERIYQMEN 1400
    KFK 1403
    Length:1,403
    Mass (Da):158,806
    Last modified:March 21, 2012 - v1
    Checksum:i90B360E3EE5BA3E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853180 Viral cRNA. Translation: AGC84161.1.
    HE649913 Genomic RNA. Translation: CCF55030.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853180 Viral cRNA. Translation: AGC84161.1 .
    HE649913 Genomic RNA. Translation: CCF55030.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    [Graphical view ]
    Pfami PF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Hoeper D.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Germany.

    Entry informationi

    Entry nameiGP_SBVBH
    AccessioniPrimary (citable) accession number: H2AM12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2013
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3