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H2AM12

- GP_SBVBH

UniProt

H2AM12 - GP_SBVBH

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Protein

Envelope glycoprotein

Gene

GP

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs (By similarity).By similarity
Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 14031386Envelope glycoproteinPRO_0000422470Add
BLAST
Chaini18 – 308291Glycoprotein G2PRO_0000422471Add
BLAST
Chaini309 – 466158Non-structural protein NSmPRO_0000422472Add
BLAST
Chaini467 – 1403937Glycoprotein G1PRO_0000422473Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini231 – 31484CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini336 – 36126LumenalSequence AnalysisAdd
BLAST
Topological domaini383 – 44866CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini470 – 1361892LumenalSequence AnalysisAdd
BLAST
Topological domaini1383 – 140321CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei210 – 23021HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Transmembranei449 – 46921HelicalSequence AnalysisAdd
BLAST
Transmembranei1362 – 138221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

H2AM12-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV
60 70 80 90 100
KDDISIIKSN AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI
110 120 130 140 150
LDIDNTGTLI PKMHTCRVEC EIALNKDTGE VILNSYRINH YRISGTMHVS
160 170 180 190 200
GWFKNKIEIP LENTCESIEV TCGLKTLNFH ACFHTHKSCT RYFKGSILPE
210 220 230 240 250
LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP IFYPFVKLYA
260 270 280 290 300
YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG
310 320 330 340 350
YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI
360 370 380 390 400
TCKRELANIK SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM
410 420 430 440 450
VHERRGLKIM DNFTNKCLSC VCAENKGLTI HRASEKCLFK FESSYNRTGL
460 470 480 490 500
IIFMLLLVPT IVMTQETSIN CKNIQSTQLT IEHLSKCMAF YQNKTSSPVV
510 520 530 540 550
INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV YYEYIKSQLC
560 570 580 590 600
PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS
610 620 630 640 650
TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK
660 670 680 690 700
DYQALRHIQG KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS
710 720 730 740 750
LIKGAHRNLD QKDPGPTPIL VCKSPQKVVC YSPRGVTHPG DYISCKSKMY
760 770 780 790 800
KWPSLGVYKH NRDQQQACSS DTHCLEMFEP AERTITTKIC KVSDMTYSES
810 820 830 840 850
PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK AHSKTNDITL
860 870 880 890 900
YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ
910 920 930 940 950
SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA
960 970 980 990 1000
INGLSAGINI AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH
1010 1020 1030 1040 1050
EEVCTGKCPS PIPHQDGWVT FSKERSSNWG CEEWGCLAIN DGCLYGSCQD
1060 1070 1080 1090 1100
IIRPEYKIYK KSSIEQKDVE VCITMAHESF CSTVDVLQPL ISDRIQLDIQ
1110 1120 1130 1140 1150
TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS EGIIGSGTPK
1160 1170 1180 1190 1200
FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS
1210 1220 1230 1240 1250
SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST
1260 1270 1280 1290 1300
NTIGSCSIKS NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA
1310 1320 1330 1340 1350
YTKPSISKNQ PKIVLNSLDE TSYIEQHDKK CSTWLCRVYK EGISVIFQPL
1360 1370 1380 1390 1400
FGNLSFYWRL TIYIIISLIM LILFLYILIP LCKRLKGLLE YNERIYQMEN

KFK
Length:1,403
Mass (Da):158,806
Last modified:March 21, 2012 - v1
Checksum:i90B360E3EE5BA3E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853180 Viral cRNA. Translation: AGC84161.1.
HE649913 Genomic RNA. Translation: CCF55030.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853180 Viral cRNA. Translation: AGC84161.1 .
HE649913 Genomic RNA. Translation: CCF55030.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Germany.

Entry informationi

Entry nameiGP_SBVBH
AccessioniPrimary (citable) accession number: H2AM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3