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H2AM12 (GP_SBVBH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 3 chains:

  1. Glycoprotein G2
    Short name=Gn
  2. Non-structural protein NSm
  3. Glycoprotein G1
    Short name=Gc
Gene names
Name:GP
OrganismBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifier1318464 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Protein attributes

Sequence length1403 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Non-structural protein NSm: Host Golgi apparatus membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the orthobunyavirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 14031386Envelope glycoprotein
PRO_0000422470
Chain18 – 308291Glycoprotein G2
PRO_0000422471
Chain309 – 466158Non-structural protein NSm
PRO_0000422472
Chain467 – 1403937Glycoprotein G1
PRO_0000422473

Regions

Transmembrane210 – 23021Helical; Potential
Topological domain231 – 31484Cytoplasmic Potential
Transmembrane315 – 33521Helical; Potential
Topological domain336 – 36126Lumenal Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 44866Cytoplasmic Potential
Transmembrane449 – 46921Helical; Potential
Topological domain470 – 1361892Lumenal Potential
Transmembrane1362 – 138221Helical; Potential
Topological domain1383 – 140321Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
H2AM12 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 90B360E3EE5BA3E5

FASTA1,403158,806
        10         20         30         40         50         60 
MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV KDDISIIKSN 

        70         80         90        100        110        120 
AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI LDIDNTGTLI PKMHTCRVEC 

       130        140        150        160        170        180 
EIALNKDTGE VILNSYRINH YRISGTMHVS GWFKNKIEIP LENTCESIEV TCGLKTLNFH 

       190        200        210        220        230        240 
ACFHTHKSCT RYFKGSILPE LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP 

       250        260        270        280        290        300 
IFYPFVKLYA YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG 

       310        320        330        340        350        360 
YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI TCKRELANIK 

       370        380        390        400        410        420 
SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM VHERRGLKIM DNFTNKCLSC 

       430        440        450        460        470        480 
VCAENKGLTI HRASEKCLFK FESSYNRTGL IIFMLLLVPT IVMTQETSIN CKNIQSTQLT 

       490        500        510        520        530        540 
IEHLSKCMAF YQNKTSSPVV INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV 

       550        560        570        580        590        600 
YYEYIKSQLC PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS 

       610        620        630        640        650        660 
TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK DYQALRHIQG 

       670        680        690        700        710        720 
KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS LIKGAHRNLD QKDPGPTPIL 

       730        740        750        760        770        780 
VCKSPQKVVC YSPRGVTHPG DYISCKSKMY KWPSLGVYKH NRDQQQACSS DTHCLEMFEP 

       790        800        810        820        830        840 
AERTITTKIC KVSDMTYSES PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK 

       850        860        870        880        890        900 
AHSKTNDITL YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ 

       910        920        930        940        950        960 
SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA INGLSAGINI 

       970        980        990       1000       1010       1020 
AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH EEVCTGKCPS PIPHQDGWVT 

      1030       1040       1050       1060       1070       1080 
FSKERSSNWG CEEWGCLAIN DGCLYGSCQD IIRPEYKIYK KSSIEQKDVE VCITMAHESF 

      1090       1100       1110       1120       1130       1140 
CSTVDVLQPL ISDRIQLDIQ TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS 

      1150       1160       1170       1180       1190       1200 
EGIIGSGTPK FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS 

      1210       1220       1230       1240       1250       1260 
SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST NTIGSCSIKS 

      1270       1280       1290       1300       1310       1320 
NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA YTKPSISKNQ PKIVLNSLDE 

      1330       1340       1350       1360       1370       1380 
TSYIEQHDKK CSTWLCRVYK EGISVIFQPL FGNLSFYWRL TIYIIISLIM LILFLYILIP 

      1390       1400 
LCKRLKGLLE YNERIYQMEN KFK 

« Hide

References

[1]"Novel orthobunyavirus in cattle, europe, 2011."
Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H., Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A., Mettenleiter T.C., Beer M.
Emerg. Infect. Dis. 18:469-472(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Hoeper D.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host."
Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M., McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M., Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.
PLoS Pathog. 9:E1003133-E1003133(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Germany.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JX853180 Viral cRNA. Translation: AGC84161.1.
HE649913 Genomic RNA. Translation: CCF55030.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
[Graphical view]
PfamPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
TIGRFAMsTIGR04210. bunya_NSm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_SBVBH
AccessionPrimary (citable) accession number: H2AM12
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families