SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

H2AM12

- GP_SBVBH

UniProt

H2AM12 - GP_SBVBH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Envelope glycoprotein
Gene
GP
Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei210 – 23021Helical; Reviewed prediction
Add
BLAST
Topological domaini231 – 31484Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST
Topological domaini336 – 36126Lumenal Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Topological domaini383 – 44866Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei449 – 46921Helical; Reviewed prediction
Add
BLAST
Topological domaini470 – 1361892Lumenal Reviewed prediction
Add
BLAST
Transmembranei1362 – 138221Helical; Reviewed prediction
Add
BLAST
Topological domaini1383 – 140321Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 14031386Envelope glycoprotein
PRO_0000422470Add
BLAST
Chaini18 – 308291Glycoprotein G2
PRO_0000422471Add
BLAST
Chaini309 – 466158Non-structural protein NSm
PRO_0000422472Add
BLAST
Chaini467 – 1403937Glycoprotein G1
PRO_0000422473Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

H2AM12-1 [UniParc]FASTAAdd to Basket

« Hide

MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV     50
KDDISIIKSN AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI 100
LDIDNTGTLI PKMHTCRVEC EIALNKDTGE VILNSYRINH YRISGTMHVS 150
GWFKNKIEIP LENTCESIEV TCGLKTLNFH ACFHTHKSCT RYFKGSILPE 200
LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP IFYPFVKLYA 250
YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG 300
YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI 350
TCKRELANIK SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM 400
VHERRGLKIM DNFTNKCLSC VCAENKGLTI HRASEKCLFK FESSYNRTGL 450
IIFMLLLVPT IVMTQETSIN CKNIQSTQLT IEHLSKCMAF YQNKTSSPVV 500
INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV YYEYIKSQLC 550
PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS 600
TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK 650
DYQALRHIQG KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS 700
LIKGAHRNLD QKDPGPTPIL VCKSPQKVVC YSPRGVTHPG DYISCKSKMY 750
KWPSLGVYKH NRDQQQACSS DTHCLEMFEP AERTITTKIC KVSDMTYSES 800
PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK AHSKTNDITL 850
YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ 900
SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA 950
INGLSAGINI AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH 1000
EEVCTGKCPS PIPHQDGWVT FSKERSSNWG CEEWGCLAIN DGCLYGSCQD 1050
IIRPEYKIYK KSSIEQKDVE VCITMAHESF CSTVDVLQPL ISDRIQLDIQ 1100
TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS EGIIGSGTPK 1150
FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS 1200
SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST 1250
NTIGSCSIKS NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA 1300
YTKPSISKNQ PKIVLNSLDE TSYIEQHDKK CSTWLCRVYK EGISVIFQPL 1350
FGNLSFYWRL TIYIIISLIM LILFLYILIP LCKRLKGLLE YNERIYQMEN 1400
KFK 1403
Length:1,403
Mass (Da):158,806
Last modified:March 21, 2012 - v1
Checksum:i90B360E3EE5BA3E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853180 Viral cRNA. Translation: AGC84161.1.
HE649913 Genomic RNA. Translation: CCF55030.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853180 Viral cRNA. Translation: AGC84161.1 .
HE649913 Genomic RNA. Translation: CCF55030.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Germany.

Entry informationi

Entry nameiGP_SBVBH
AccessioniPrimary (citable) accession number: H2AM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi