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H2AM11

- L_SBVBH

UniProt

H2AM11 - L_SBVBH

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. cysteine-type peptidase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Ubl conjugation pathway, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22542254RNA-directed RNA polymerase L
PRO_0000422476Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1023 – 1214192RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2AM11-1 [UniParc]FASTAAdd to Basket

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METYKINIFR DRINQCRSAE EAKDIVADLL MARHDYFGRE VCYYLDIEFR     50
QDVPAYDILL EFLPAGTAFN IRNCTPDNFI IHNGKLYIID YKVSTDHAYG 100
QKTYEKYTQI FGDALSELPF DFEVVIIRAD PLRDTIHVNS NQFLEIFGPL 150
NINLDFTWFF NLRSLIYEKY KDDDRFLEIV NQGEFTMTGP WIDEDTPELY 200
SHPVFLEFYD SLDEMAKLTF HESMTFDATR GEKWNQNLQK VINRYGNDYN 250
IFVKEAAAGI FRCEGNYPKP NHDEITIGWN QMVQRVSTER NLTQDVSKQK 300
PSIHFIWGQP DETSNATTPK LIKIAKALQN ISGESTYISA FRALGMLMDF 350
SENTALYEAH TSKLKSMARQ TSKRIDTKLE PIKIGTATIY WEQQFKLDTE 400
IMNTKDKSHL LKDFLGIGGH VQFSKKTIDD LDTDKPTILD FNKKEVIDFC 450
KFQYENVKKI LSGDNNLERI GCYLEEYGAN IASCSKDTWD QINQIGKSNY 500
WACIKDFSVL MKNMLAVSQY NRHNTFRVVC CANNNLFGFV MPSSDIKAKR 550
STLVYFLAVL HSTPQNVMHH GALHATFKTG SKYLSISKGM RLDKERCQRI 600
VSSPGLFMLT TLMFAGDNPT LNLTDVMNFT FHTSLSITKA MLSLTEPSRY 650
MIMNSLAISS HVRDYIAEKF GPYTKTSFSV VMANLIKRGC YMAYNQRDKV 700
DMRNICLTDY EITQKGVRDN RDLSSIWFEG YVSLKEYINQ IYLPFYFNSK 750
GLHEKHHVMI DLAKTILDIE RDQRLNIPGI WSTTPRKQTA NLNITIYAVA 800
KNLIMDTARH NYIRSRIENT NNLNRSICTI STFTSSKSCI KVGDFEKEKS 850
SATKKAADCM SKEIKKYTIA NPEFVDEELL NATIRHSRYE DLKKAIPNYI 900
DIMSTKVFDS LYQKIKRKEI DDKPTVYHIL SAMKNHTDFK FTFFNKGQKT 950
AKDREIFVGE FEAKMCLYLV ERISKERCKL NPDEMISEPG DSKLKKLEEL 1000
AESEIRFTAA TMKQIKERYL AEMGEASHMI AYKPHSVKIE INADMSKWSA 1050
QDVLFKYFWL FALDPALYLQ EKERILYFLC NYMQKKLILP DEMLCSILDQ 1100
RIKHEDDIIY EMTNGLSQNW VNIKRNWLQG NLNYTSSYLH SCSMNVYKDI 1150
LKRAATLLEG EVLVNSMVHS DDNHTSIVMI QDKLDDDIVI EFSAKLFEKI 1200
CLTFGNQANM KKTYITNFIK EFVSLFNIYG EPFSVYGRFI LTSVGDCAFL 1250
GPYEDVASRL SATQTAIKHG APPSLAWTAI ALTQWITHST YNMLPGQIND 1300
PTSSLPSHDR FELPIELCGL INSELPTIAI AGLEADNLSY LVRLSKRMSP 1350
IHLCREPIQH QYENIHTWDI SKLTQCDIFR LKLLRYMTLD STMSSDDGMG 1400
ETSEMRSRSL LTPRKFTTAS SLSRLHSYAD YQKTIQDQQK IEELFEYFIA 1450
NPQLLVTKGE TCEEFCMSVL FRYNSRKFKE SLSIQNPAQL FIEQVLFANK 1500
PMIDYTSIHD RLFGIQDDPN INDATCIIGK KTFVETYQQI KIDVEKFTLD 1550
VEDIKTIYSF CIMNDPILVA CANNLLISIQ GVEMQRLGMT CCYMPEIKSL 1600
KVIYHSPALV LRAYVTDNYE QKGMEPDEMR RDIYHLEEFI EKTKLRTNMQ 1650
GRIANNEIKL MKRDLKFEVQ ELTKFYQICY EYVKSTEHKI KIFILPKKAY 1700
TPIDFCSLVT GNLISDNKWM VVHYLKQITV PAKKAQIATS IDLEIQIAYE 1750
CFRLIAHFAD MFLNDDSKKA YINAIINTYT YKDVQVSSLY KKIKNSRLRS 1800
KIIPLLYHLG DLQQIDVDRF DAEKAEEQIT WNNWQTSREF TTGPIDLSIK 1850
GYGRSIRIVG EDNKLTAAEM QLSRVRSDIV SRHGQALLNK PHGLKLEKME 1900
PVTDLNPKLW YIAYQLREKK RYHYGVFSTS YIEEHNSRIE ASRIRKTNKW 1950
IPVCPIAISK QSSDGKPSLA KIPMLNIGEI KFTKLQIAVD DHAMIRKAPF 2000
SKMVFFDGPP IQSGGIDIGK LMKNQNILNL RLDNIQSITL LDLCRIFSCR 2050
GSKVDQDAFE FLSDEPLDED VIDELDSSPA LVVSYTKKST KSNSFKNVIV 2100
RALIRECDIF EDIMDITDDG FTSDSNLEVL ENLTWILNML ATNQWSTELL 2150
ACIHMCLYRN EMDHIYHNFQ VPEIFVDNPI SLNVKWDEVI MFLNILRDRD 2200
YKFEPWVSIL NHSLTKAIEY AYKKMEEERK QKSTGINKFL KGKKMGGRSK 2250
FDFQ 2254
Length:2,254
Mass (Da):261,027
Last modified:March 21, 2012 - v1
Checksum:i4FE8F8FCEC43B644
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853179 Viral cRNA. Translation: AGC84160.1.
HE649912 Genomic RNA. Translation: CCF55029.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX853179 Viral cRNA. Translation: AGC84160.1 .
HE649912 Genomic RNA. Translation: CCF55029.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Germany.

Entry informationi

Entry nameiL_SBVBH
AccessioniPrimary (citable) accession number: H2AM11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi