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H2AM11 (L_SBVBH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifier1318464 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Protein attributes

Sequence length2254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the orthobunyavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22542254RNA-directed RNA polymerase L
PRO_0000422476

Regions

Domain1023 – 1214192RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
H2AM11 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 4FE8F8FCEC43B644

FASTA2,254261,027
        10         20         30         40         50         60 
METYKINIFR DRINQCRSAE EAKDIVADLL MARHDYFGRE VCYYLDIEFR QDVPAYDILL 

        70         80         90        100        110        120 
EFLPAGTAFN IRNCTPDNFI IHNGKLYIID YKVSTDHAYG QKTYEKYTQI FGDALSELPF 

       130        140        150        160        170        180 
DFEVVIIRAD PLRDTIHVNS NQFLEIFGPL NINLDFTWFF NLRSLIYEKY KDDDRFLEIV 

       190        200        210        220        230        240 
NQGEFTMTGP WIDEDTPELY SHPVFLEFYD SLDEMAKLTF HESMTFDATR GEKWNQNLQK 

       250        260        270        280        290        300 
VINRYGNDYN IFVKEAAAGI FRCEGNYPKP NHDEITIGWN QMVQRVSTER NLTQDVSKQK 

       310        320        330        340        350        360 
PSIHFIWGQP DETSNATTPK LIKIAKALQN ISGESTYISA FRALGMLMDF SENTALYEAH 

       370        380        390        400        410        420 
TSKLKSMARQ TSKRIDTKLE PIKIGTATIY WEQQFKLDTE IMNTKDKSHL LKDFLGIGGH 

       430        440        450        460        470        480 
VQFSKKTIDD LDTDKPTILD FNKKEVIDFC KFQYENVKKI LSGDNNLERI GCYLEEYGAN 

       490        500        510        520        530        540 
IASCSKDTWD QINQIGKSNY WACIKDFSVL MKNMLAVSQY NRHNTFRVVC CANNNLFGFV 

       550        560        570        580        590        600 
MPSSDIKAKR STLVYFLAVL HSTPQNVMHH GALHATFKTG SKYLSISKGM RLDKERCQRI 

       610        620        630        640        650        660 
VSSPGLFMLT TLMFAGDNPT LNLTDVMNFT FHTSLSITKA MLSLTEPSRY MIMNSLAISS 

       670        680        690        700        710        720 
HVRDYIAEKF GPYTKTSFSV VMANLIKRGC YMAYNQRDKV DMRNICLTDY EITQKGVRDN 

       730        740        750        760        770        780 
RDLSSIWFEG YVSLKEYINQ IYLPFYFNSK GLHEKHHVMI DLAKTILDIE RDQRLNIPGI 

       790        800        810        820        830        840 
WSTTPRKQTA NLNITIYAVA KNLIMDTARH NYIRSRIENT NNLNRSICTI STFTSSKSCI 

       850        860        870        880        890        900 
KVGDFEKEKS SATKKAADCM SKEIKKYTIA NPEFVDEELL NATIRHSRYE DLKKAIPNYI 

       910        920        930        940        950        960 
DIMSTKVFDS LYQKIKRKEI DDKPTVYHIL SAMKNHTDFK FTFFNKGQKT AKDREIFVGE 

       970        980        990       1000       1010       1020 
FEAKMCLYLV ERISKERCKL NPDEMISEPG DSKLKKLEEL AESEIRFTAA TMKQIKERYL 

      1030       1040       1050       1060       1070       1080 
AEMGEASHMI AYKPHSVKIE INADMSKWSA QDVLFKYFWL FALDPALYLQ EKERILYFLC 

      1090       1100       1110       1120       1130       1140 
NYMQKKLILP DEMLCSILDQ RIKHEDDIIY EMTNGLSQNW VNIKRNWLQG NLNYTSSYLH 

      1150       1160       1170       1180       1190       1200 
SCSMNVYKDI LKRAATLLEG EVLVNSMVHS DDNHTSIVMI QDKLDDDIVI EFSAKLFEKI 

      1210       1220       1230       1240       1250       1260 
CLTFGNQANM KKTYITNFIK EFVSLFNIYG EPFSVYGRFI LTSVGDCAFL GPYEDVASRL 

      1270       1280       1290       1300       1310       1320 
SATQTAIKHG APPSLAWTAI ALTQWITHST YNMLPGQIND PTSSLPSHDR FELPIELCGL 

      1330       1340       1350       1360       1370       1380 
INSELPTIAI AGLEADNLSY LVRLSKRMSP IHLCREPIQH QYENIHTWDI SKLTQCDIFR 

      1390       1400       1410       1420       1430       1440 
LKLLRYMTLD STMSSDDGMG ETSEMRSRSL LTPRKFTTAS SLSRLHSYAD YQKTIQDQQK 

      1450       1460       1470       1480       1490       1500 
IEELFEYFIA NPQLLVTKGE TCEEFCMSVL FRYNSRKFKE SLSIQNPAQL FIEQVLFANK 

      1510       1520       1530       1540       1550       1560 
PMIDYTSIHD RLFGIQDDPN INDATCIIGK KTFVETYQQI KIDVEKFTLD VEDIKTIYSF 

      1570       1580       1590       1600       1610       1620 
CIMNDPILVA CANNLLISIQ GVEMQRLGMT CCYMPEIKSL KVIYHSPALV LRAYVTDNYE 

      1630       1640       1650       1660       1670       1680 
QKGMEPDEMR RDIYHLEEFI EKTKLRTNMQ GRIANNEIKL MKRDLKFEVQ ELTKFYQICY 

      1690       1700       1710       1720       1730       1740 
EYVKSTEHKI KIFILPKKAY TPIDFCSLVT GNLISDNKWM VVHYLKQITV PAKKAQIATS 

      1750       1760       1770       1780       1790       1800 
IDLEIQIAYE CFRLIAHFAD MFLNDDSKKA YINAIINTYT YKDVQVSSLY KKIKNSRLRS 

      1810       1820       1830       1840       1850       1860 
KIIPLLYHLG DLQQIDVDRF DAEKAEEQIT WNNWQTSREF TTGPIDLSIK GYGRSIRIVG 

      1870       1880       1890       1900       1910       1920 
EDNKLTAAEM QLSRVRSDIV SRHGQALLNK PHGLKLEKME PVTDLNPKLW YIAYQLREKK 

      1930       1940       1950       1960       1970       1980 
RYHYGVFSTS YIEEHNSRIE ASRIRKTNKW IPVCPIAISK QSSDGKPSLA KIPMLNIGEI 

      1990       2000       2010       2020       2030       2040 
KFTKLQIAVD DHAMIRKAPF SKMVFFDGPP IQSGGIDIGK LMKNQNILNL RLDNIQSITL 

      2050       2060       2070       2080       2090       2100 
LDLCRIFSCR GSKVDQDAFE FLSDEPLDED VIDELDSSPA LVVSYTKKST KSNSFKNVIV 

      2110       2120       2130       2140       2150       2160 
RALIRECDIF EDIMDITDDG FTSDSNLEVL ENLTWILNML ATNQWSTELL ACIHMCLYRN 

      2170       2180       2190       2200       2210       2220 
EMDHIYHNFQ VPEIFVDNPI SLNVKWDEVI MFLNILRDRD YKFEPWVSIL NHSLTKAIEY 

      2230       2240       2250 
AYKKMEEERK QKSTGINKFL KGKKMGGRSK FDFQ 

« Hide

References

[1]"Novel orthobunyavirus in cattle, europe, 2011."
Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H., Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A., Mettenleiter T.C., Beer M.
Emerg. Infect. Dis. 18:469-472(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Hoeper D.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host."
Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M., McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M., Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.
PLoS Pathog. 9:E1003133-E1003133(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Germany.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JX853179 Viral cRNA. Translation: AGC84160.1.
HE649912 Genomic RNA. Translation: CCF55029.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_SBVBH
AccessionPrimary (citable) accession number: H2AM11
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families