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H2AM11

- L_SBVBH

UniProt

H2AM11 - L_SBVBH

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome.By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Ubl conjugation pathway, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic identifieri1318464 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22542254RNA-directed RNA polymerase LPRO_0000422476Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1023 – 1214192RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2AM11-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
METYKINIFR DRINQCRSAE EAKDIVADLL MARHDYFGRE VCYYLDIEFR
60 70 80 90 100
QDVPAYDILL EFLPAGTAFN IRNCTPDNFI IHNGKLYIID YKVSTDHAYG
110 120 130 140 150
QKTYEKYTQI FGDALSELPF DFEVVIIRAD PLRDTIHVNS NQFLEIFGPL
160 170 180 190 200
NINLDFTWFF NLRSLIYEKY KDDDRFLEIV NQGEFTMTGP WIDEDTPELY
210 220 230 240 250
SHPVFLEFYD SLDEMAKLTF HESMTFDATR GEKWNQNLQK VINRYGNDYN
260 270 280 290 300
IFVKEAAAGI FRCEGNYPKP NHDEITIGWN QMVQRVSTER NLTQDVSKQK
310 320 330 340 350
PSIHFIWGQP DETSNATTPK LIKIAKALQN ISGESTYISA FRALGMLMDF
360 370 380 390 400
SENTALYEAH TSKLKSMARQ TSKRIDTKLE PIKIGTATIY WEQQFKLDTE
410 420 430 440 450
IMNTKDKSHL LKDFLGIGGH VQFSKKTIDD LDTDKPTILD FNKKEVIDFC
460 470 480 490 500
KFQYENVKKI LSGDNNLERI GCYLEEYGAN IASCSKDTWD QINQIGKSNY
510 520 530 540 550
WACIKDFSVL MKNMLAVSQY NRHNTFRVVC CANNNLFGFV MPSSDIKAKR
560 570 580 590 600
STLVYFLAVL HSTPQNVMHH GALHATFKTG SKYLSISKGM RLDKERCQRI
610 620 630 640 650
VSSPGLFMLT TLMFAGDNPT LNLTDVMNFT FHTSLSITKA MLSLTEPSRY
660 670 680 690 700
MIMNSLAISS HVRDYIAEKF GPYTKTSFSV VMANLIKRGC YMAYNQRDKV
710 720 730 740 750
DMRNICLTDY EITQKGVRDN RDLSSIWFEG YVSLKEYINQ IYLPFYFNSK
760 770 780 790 800
GLHEKHHVMI DLAKTILDIE RDQRLNIPGI WSTTPRKQTA NLNITIYAVA
810 820 830 840 850
KNLIMDTARH NYIRSRIENT NNLNRSICTI STFTSSKSCI KVGDFEKEKS
860 870 880 890 900
SATKKAADCM SKEIKKYTIA NPEFVDEELL NATIRHSRYE DLKKAIPNYI
910 920 930 940 950
DIMSTKVFDS LYQKIKRKEI DDKPTVYHIL SAMKNHTDFK FTFFNKGQKT
960 970 980 990 1000
AKDREIFVGE FEAKMCLYLV ERISKERCKL NPDEMISEPG DSKLKKLEEL
1010 1020 1030 1040 1050
AESEIRFTAA TMKQIKERYL AEMGEASHMI AYKPHSVKIE INADMSKWSA
1060 1070 1080 1090 1100
QDVLFKYFWL FALDPALYLQ EKERILYFLC NYMQKKLILP DEMLCSILDQ
1110 1120 1130 1140 1150
RIKHEDDIIY EMTNGLSQNW VNIKRNWLQG NLNYTSSYLH SCSMNVYKDI
1160 1170 1180 1190 1200
LKRAATLLEG EVLVNSMVHS DDNHTSIVMI QDKLDDDIVI EFSAKLFEKI
1210 1220 1230 1240 1250
CLTFGNQANM KKTYITNFIK EFVSLFNIYG EPFSVYGRFI LTSVGDCAFL
1260 1270 1280 1290 1300
GPYEDVASRL SATQTAIKHG APPSLAWTAI ALTQWITHST YNMLPGQIND
1310 1320 1330 1340 1350
PTSSLPSHDR FELPIELCGL INSELPTIAI AGLEADNLSY LVRLSKRMSP
1360 1370 1380 1390 1400
IHLCREPIQH QYENIHTWDI SKLTQCDIFR LKLLRYMTLD STMSSDDGMG
1410 1420 1430 1440 1450
ETSEMRSRSL LTPRKFTTAS SLSRLHSYAD YQKTIQDQQK IEELFEYFIA
1460 1470 1480 1490 1500
NPQLLVTKGE TCEEFCMSVL FRYNSRKFKE SLSIQNPAQL FIEQVLFANK
1510 1520 1530 1540 1550
PMIDYTSIHD RLFGIQDDPN INDATCIIGK KTFVETYQQI KIDVEKFTLD
1560 1570 1580 1590 1600
VEDIKTIYSF CIMNDPILVA CANNLLISIQ GVEMQRLGMT CCYMPEIKSL
1610 1620 1630 1640 1650
KVIYHSPALV LRAYVTDNYE QKGMEPDEMR RDIYHLEEFI EKTKLRTNMQ
1660 1670 1680 1690 1700
GRIANNEIKL MKRDLKFEVQ ELTKFYQICY EYVKSTEHKI KIFILPKKAY
1710 1720 1730 1740 1750
TPIDFCSLVT GNLISDNKWM VVHYLKQITV PAKKAQIATS IDLEIQIAYE
1760 1770 1780 1790 1800
CFRLIAHFAD MFLNDDSKKA YINAIINTYT YKDVQVSSLY KKIKNSRLRS
1810 1820 1830 1840 1850
KIIPLLYHLG DLQQIDVDRF DAEKAEEQIT WNNWQTSREF TTGPIDLSIK
1860 1870 1880 1890 1900
GYGRSIRIVG EDNKLTAAEM QLSRVRSDIV SRHGQALLNK PHGLKLEKME
1910 1920 1930 1940 1950
PVTDLNPKLW YIAYQLREKK RYHYGVFSTS YIEEHNSRIE ASRIRKTNKW
1960 1970 1980 1990 2000
IPVCPIAISK QSSDGKPSLA KIPMLNIGEI KFTKLQIAVD DHAMIRKAPF
2010 2020 2030 2040 2050
SKMVFFDGPP IQSGGIDIGK LMKNQNILNL RLDNIQSITL LDLCRIFSCR
2060 2070 2080 2090 2100
GSKVDQDAFE FLSDEPLDED VIDELDSSPA LVVSYTKKST KSNSFKNVIV
2110 2120 2130 2140 2150
RALIRECDIF EDIMDITDDG FTSDSNLEVL ENLTWILNML ATNQWSTELL
2160 2170 2180 2190 2200
ACIHMCLYRN EMDHIYHNFQ VPEIFVDNPI SLNVKWDEVI MFLNILRDRD
2210 2220 2230 2240 2250
YKFEPWVSIL NHSLTKAIEY AYKKMEEERK QKSTGINKFL KGKKMGGRSK

FDFQ
Length:2,254
Mass (Da):261,027
Last modified:March 21, 2012 - v1
Checksum:i4FE8F8FCEC43B644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853179 Viral cRNA. Translation: AGC84160.1.
HE649912 Genomic RNA. Translation: CCF55029.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853179 Viral cRNA. Translation: AGC84160.1 .
HE649912 Genomic RNA. Translation: CCF55029.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Hoeper D.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Germany.

Entry informationi

Entry nameiL_SBVBH
AccessioniPrimary (citable) accession number: H2AM11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3