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H2AM11

- L_SBVBH

UniProt

H2AM11 - L_SBVBH

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome.By similarity

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

    Keywords - Biological processi

    Ubl conjugation pathway, Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
    Taxonomic identifieri1318464 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirusunclassified Orthobunyavirus

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22542254RNA-directed RNA polymerase LPRO_0000422476Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1023 – 1214192RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR026382. CapSnatchArena.
    IPR029124. L_protein_N.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF15518. L_protein_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2AM11-1 [UniParc]FASTAAdd to Basket

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    METYKINIFR DRINQCRSAE EAKDIVADLL MARHDYFGRE VCYYLDIEFR     50
    QDVPAYDILL EFLPAGTAFN IRNCTPDNFI IHNGKLYIID YKVSTDHAYG 100
    QKTYEKYTQI FGDALSELPF DFEVVIIRAD PLRDTIHVNS NQFLEIFGPL 150
    NINLDFTWFF NLRSLIYEKY KDDDRFLEIV NQGEFTMTGP WIDEDTPELY 200
    SHPVFLEFYD SLDEMAKLTF HESMTFDATR GEKWNQNLQK VINRYGNDYN 250
    IFVKEAAAGI FRCEGNYPKP NHDEITIGWN QMVQRVSTER NLTQDVSKQK 300
    PSIHFIWGQP DETSNATTPK LIKIAKALQN ISGESTYISA FRALGMLMDF 350
    SENTALYEAH TSKLKSMARQ TSKRIDTKLE PIKIGTATIY WEQQFKLDTE 400
    IMNTKDKSHL LKDFLGIGGH VQFSKKTIDD LDTDKPTILD FNKKEVIDFC 450
    KFQYENVKKI LSGDNNLERI GCYLEEYGAN IASCSKDTWD QINQIGKSNY 500
    WACIKDFSVL MKNMLAVSQY NRHNTFRVVC CANNNLFGFV MPSSDIKAKR 550
    STLVYFLAVL HSTPQNVMHH GALHATFKTG SKYLSISKGM RLDKERCQRI 600
    VSSPGLFMLT TLMFAGDNPT LNLTDVMNFT FHTSLSITKA MLSLTEPSRY 650
    MIMNSLAISS HVRDYIAEKF GPYTKTSFSV VMANLIKRGC YMAYNQRDKV 700
    DMRNICLTDY EITQKGVRDN RDLSSIWFEG YVSLKEYINQ IYLPFYFNSK 750
    GLHEKHHVMI DLAKTILDIE RDQRLNIPGI WSTTPRKQTA NLNITIYAVA 800
    KNLIMDTARH NYIRSRIENT NNLNRSICTI STFTSSKSCI KVGDFEKEKS 850
    SATKKAADCM SKEIKKYTIA NPEFVDEELL NATIRHSRYE DLKKAIPNYI 900
    DIMSTKVFDS LYQKIKRKEI DDKPTVYHIL SAMKNHTDFK FTFFNKGQKT 950
    AKDREIFVGE FEAKMCLYLV ERISKERCKL NPDEMISEPG DSKLKKLEEL 1000
    AESEIRFTAA TMKQIKERYL AEMGEASHMI AYKPHSVKIE INADMSKWSA 1050
    QDVLFKYFWL FALDPALYLQ EKERILYFLC NYMQKKLILP DEMLCSILDQ 1100
    RIKHEDDIIY EMTNGLSQNW VNIKRNWLQG NLNYTSSYLH SCSMNVYKDI 1150
    LKRAATLLEG EVLVNSMVHS DDNHTSIVMI QDKLDDDIVI EFSAKLFEKI 1200
    CLTFGNQANM KKTYITNFIK EFVSLFNIYG EPFSVYGRFI LTSVGDCAFL 1250
    GPYEDVASRL SATQTAIKHG APPSLAWTAI ALTQWITHST YNMLPGQIND 1300
    PTSSLPSHDR FELPIELCGL INSELPTIAI AGLEADNLSY LVRLSKRMSP 1350
    IHLCREPIQH QYENIHTWDI SKLTQCDIFR LKLLRYMTLD STMSSDDGMG 1400
    ETSEMRSRSL LTPRKFTTAS SLSRLHSYAD YQKTIQDQQK IEELFEYFIA 1450
    NPQLLVTKGE TCEEFCMSVL FRYNSRKFKE SLSIQNPAQL FIEQVLFANK 1500
    PMIDYTSIHD RLFGIQDDPN INDATCIIGK KTFVETYQQI KIDVEKFTLD 1550
    VEDIKTIYSF CIMNDPILVA CANNLLISIQ GVEMQRLGMT CCYMPEIKSL 1600
    KVIYHSPALV LRAYVTDNYE QKGMEPDEMR RDIYHLEEFI EKTKLRTNMQ 1650
    GRIANNEIKL MKRDLKFEVQ ELTKFYQICY EYVKSTEHKI KIFILPKKAY 1700
    TPIDFCSLVT GNLISDNKWM VVHYLKQITV PAKKAQIATS IDLEIQIAYE 1750
    CFRLIAHFAD MFLNDDSKKA YINAIINTYT YKDVQVSSLY KKIKNSRLRS 1800
    KIIPLLYHLG DLQQIDVDRF DAEKAEEQIT WNNWQTSREF TTGPIDLSIK 1850
    GYGRSIRIVG EDNKLTAAEM QLSRVRSDIV SRHGQALLNK PHGLKLEKME 1900
    PVTDLNPKLW YIAYQLREKK RYHYGVFSTS YIEEHNSRIE ASRIRKTNKW 1950
    IPVCPIAISK QSSDGKPSLA KIPMLNIGEI KFTKLQIAVD DHAMIRKAPF 2000
    SKMVFFDGPP IQSGGIDIGK LMKNQNILNL RLDNIQSITL LDLCRIFSCR 2050
    GSKVDQDAFE FLSDEPLDED VIDELDSSPA LVVSYTKKST KSNSFKNVIV 2100
    RALIRECDIF EDIMDITDDG FTSDSNLEVL ENLTWILNML ATNQWSTELL 2150
    ACIHMCLYRN EMDHIYHNFQ VPEIFVDNPI SLNVKWDEVI MFLNILRDRD 2200
    YKFEPWVSIL NHSLTKAIEY AYKKMEEERK QKSTGINKFL KGKKMGGRSK 2250
    FDFQ 2254
    Length:2,254
    Mass (Da):261,027
    Last modified:March 21, 2012 - v1
    Checksum:i4FE8F8FCEC43B644
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853179 Viral cRNA. Translation: AGC84160.1.
    HE649912 Genomic RNA. Translation: CCF55029.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX853179 Viral cRNA. Translation: AGC84160.1 .
    HE649912 Genomic RNA. Translation: CCF55029.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR026382. CapSnatchArena.
    IPR029124. L_protein_N.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF15518. L_protein_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Hoeper D.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Germany.

    Entry informationi

    Entry nameiL_SBVBH
    AccessioniPrimary (citable) accession number: H2AM11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2013
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3