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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus macedonicus (strain ACA-DC 198)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei263Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei310Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SMA_1798Imported
OrganismiStreptococcus macedonicus (strain ACA-DC 198)Imported
Taxonomic identifieri1116231 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000007152 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi1116231.SMA_1798.

Structurei

3D structure databases

ProteinModelPortaliH2A8I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 367Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiPWEILCS.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2A8I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSLHRPTK AVIDLDAICQ NIDAVKANIP QDKKAFAVVK ANAYGHGATN
60 70 80 90 100
VAQAIHHLVD GFCVSNIDEA LELREAGIEE TILILGVIMP DEVALARDYH
110 120 130 140 150
VTLTVASQEW LDLANEQGIS LAGLDVHLKV DSGMGRIGVR SLDEAENVIA
160 170 180 190 200
NLKKAGANVE GIFTHFATAD EADDTKFNEQ LEFFTNLVNN LSDKPGIVHA
210 220 230 240 250
SNSATSIWHS ETIFNLVRLG IVMYGLNPSG TELDLPYPLK PALSLESSLV
260 270 280 290 300
HVKMIPAGAT VGYGATYTAQ KEEYIATVPI GYADGWTRDL QGFSVLVNGE
310 320 330 340 350
FCEIVGRVSM DQITIRLPEK LTIGTKVTLI GQEGDKVISA TDLAQKRGTI
360
NYEVLCLLSD RIPRVYSK
Length:368
Mass (Da):39,871
Last modified:March 21, 2012 - v1
Checksum:iBEF8000BFAC56E2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE613569 Genomic DNA. Translation: CCF03089.1.
RefSeqiWP_014295213.1. NC_016749.1.

Genome annotation databases

EnsemblBacteriaiCCF03089; CCF03089; SMA_1798.
KEGGismn:SMA_1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE613569 Genomic DNA. Translation: CCF03089.1.
RefSeqiWP_014295213.1. NC_016749.1.

3D structure databases

ProteinModelPortaliH2A8I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1116231.SMA_1798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCF03089; CCF03089; SMA_1798.
KEGGismn:SMA_1798.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiPWEILCS.
OrthoDBiPOG091H022F.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2A8I8_STRMD
AccessioniPrimary (citable) accession number: H2A8I8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 30, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.