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H2A8I8

- H2A8I8_STRMD

UniProt

H2A8I8 - H2A8I8_STRMD

Protein

Alanine racemase

Gene

alr

Organism
Streptococcus macedonicus (strain ACA-DC 198)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:SMA_1798Imported
    OrganismiStreptococcus macedonicus (strain ACA-DC 198)Imported
    Taxonomic identifieri1116231 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000007152: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH2A8I8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2A8I8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISSLHRPTK AVIDLDAICQ NIDAVKANIP QDKKAFAVVK ANAYGHGATN    50
    VAQAIHHLVD GFCVSNIDEA LELREAGIEE TILILGVIMP DEVALARDYH 100
    VTLTVASQEW LDLANEQGIS LAGLDVHLKV DSGMGRIGVR SLDEAENVIA 150
    NLKKAGANVE GIFTHFATAD EADDTKFNEQ LEFFTNLVNN LSDKPGIVHA 200
    SNSATSIWHS ETIFNLVRLG IVMYGLNPSG TELDLPYPLK PALSLESSLV 250
    HVKMIPAGAT VGYGATYTAQ KEEYIATVPI GYADGWTRDL QGFSVLVNGE 300
    FCEIVGRVSM DQITIRLPEK LTIGTKVTLI GQEGDKVISA TDLAQKRGTI 350
    NYEVLCLLSD RIPRVYSK 368
    Length:368
    Mass (Da):39,871
    Last modified:March 21, 2012 - v1
    Checksum:iBEF8000BFAC56E2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE613569 Genomic DNA. Translation: CCF03089.1.
    RefSeqiYP_005095394.1. NC_016749.1.

    Genome annotation databases

    EnsemblBacteriaiCCF03089; CCF03089; SMA_1798.
    GeneIDi11602221.
    KEGGismn:SMA_1798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE613569 Genomic DNA. Translation: CCF03089.1 .
    RefSeqi YP_005095394.1. NC_016749.1.

    3D structure databases

    ProteinModelPortali H2A8I8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCF03089 ; CCF03089 ; SMA_1798 .
    GeneIDi 11602221.
    KEGGi smn:SMA_1798.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dairy isolate Streptococcus macedonicus ACA-DC 198."
      Papadimitriou K., Ferreira S., Papandreou N.C., Mavrogonatou E., Supply P., Pot B., Tsakalidou E.
      J. Bacteriol. 194:1838-1839(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ACA-DC 198Imported.

    Entry informationi

    Entry nameiH2A8I8_STRMD
    AccessioniPrimary (citable) accession number: H2A8I8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3