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H2A8I8 (H2A8I8_STRMD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. RuleBase RU004247 HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site401Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2631Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1361Substrate By similarity HAMAP-Rule MF_01201
Binding site3101Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
H2A8I8 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: BEF8000BFAC56E2D

FASTA36839,871
        10         20         30         40         50         60 
MISSLHRPTK AVIDLDAICQ NIDAVKANIP QDKKAFAVVK ANAYGHGATN VAQAIHHLVD 

        70         80         90        100        110        120 
GFCVSNIDEA LELREAGIEE TILILGVIMP DEVALARDYH VTLTVASQEW LDLANEQGIS 

       130        140        150        160        170        180 
LAGLDVHLKV DSGMGRIGVR SLDEAENVIA NLKKAGANVE GIFTHFATAD EADDTKFNEQ 

       190        200        210        220        230        240 
LEFFTNLVNN LSDKPGIVHA SNSATSIWHS ETIFNLVRLG IVMYGLNPSG TELDLPYPLK 

       250        260        270        280        290        300 
PALSLESSLV HVKMIPAGAT VGYGATYTAQ KEEYIATVPI GYADGWTRDL QGFSVLVNGE 

       310        320        330        340        350        360 
FCEIVGRVSM DQITIRLPEK LTIGTKVTLI GQEGDKVISA TDLAQKRGTI NYEVLCLLSD 


RIPRVYSK 

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References

[1]"Complete genome sequence of the dairy isolate Streptococcus macedonicus ACA-DC 198."
Papadimitriou K., Ferreira S., Papandreou N.C., Mavrogonatou E., Supply P., Pot B., Tsakalidou E.
J. Bacteriol. 194:1838-1839(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ACA-DC 198 EMBL CCF03089.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE613569 Genomic DNA. Translation: CCF03089.1.
RefSeqYP_005095394.1. NC_016749.1.

3D structure databases

ProteinModelPortalH2A8I8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCF03089; CCF03089; SMA_1798.
GeneID11602221.
KEGGsmn:SMA_1798.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2A8I8_STRMD
AccessionPrimary (citable) accession number: H2A8I8
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)