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H2A0L6

- HEX_PINMG

UniProt

H2A0L6 - HEX_PINMG

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Protein

Putative beta-hexosaminidase

Gene
N/A
Organism
Pinctada margaritifera (Black-lipped pearl oyster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

Pathwayi

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. chitin catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00349.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
OrganismiPinctada margaritifera (Black-lipped pearl oyster)
Taxonomic identifieri102329 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPterioidaPterioideaPteriidaePinctada

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 11351112Putative beta-hexosaminidasePRO_0000418019Add
BLAST

Expressioni

Tissue specificityi

Prismatic layer of shell (at protein level). Expressed primarily in the mantle with highest level in the mantle edge and lower level in the mantle pallium.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi937 – 100468Pro-richAdd
BLAST
Compositional biasi1006 – 1133128Gln-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

H2A0L6-1 [UniParc]FASTAAdd to Basket

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MKWVKSGVGI LGILLTICHA VTSQGHILDI TDSLKITFKT LSNFGPRAQS     50
IQNVTIENVG IKDIPDSGWR CYFCHDQLLF PGTFNLARNQ YFLRPILDNY 100
VVLSDGFLLE FIKGCMYRIT PIPRNAPIKT RDKREFTLLA EQFSVSKYDS 150
FPKWYCETIS GGNTEVGIIR NTENLKYVED FDSSYNWFRI PHDFRSVPLQ 200
PQDRFSANHK ASSVDECKYK VIPTPVKASV SKVQRNFGTT VYYGTTDTSI 250
RGREKLFKVA EQLALKHNLG LVEITPGLTV NNGISLVVTG NYVERNIPSP 300
DEAYSLTVTA DLISIEAPAL PGLINGIETI HSLSAWDMAL PYGGIKDFPR 350
FPFRGIFLDI ASNFPGYNYI KKFLTVMAQY KLNKLVLPMY NNEGFRLQLN 400
DSPRYEFQAL HMIGGKRCHD LKEEKCLFSQ LGSGPDSSGG YLTKAQMTDL 450
IKTADLLNIE IIMSMNIGES ARGAIVPLKQ SPHSRLLYDP DDTDFVDRFY 500
PQKDTSMNPC REETTYFYDH MLKQLKDIYN AASVPLKTIM IGSKVNFDQV 550
LNSKYCYASN LNSTQRLMAR GNLERNINGF KLNFTKRLVK TAHDNGIKEV 600
MAIDDVFTTE FDAEGNTPNT VYDTKNSDNS TRFNATVTAV HSRYDTVRDE 650
RLWKRGDRFA ELGYKVILSP PILDFNYAVE PDPDRPGDYD SVIRNISFSK 700
LFRFVPDSRC CNIPNAIQHD CALESDCTTA GAKDSYIGTL GKLDTRKLRS 750
LKDWNELLFP RLLIFAERSW HKSSWEDSFG PHRASVNNIT RQLITNYTVP 800
NWNDINNEES KVLGCISRKE KLRLMHEDGL KPYVEPPGAR LLGGNTMRIA 850
ASTTEDSFWV QASVNGNPWT DNVKILDVNP TDSVRLRTVH PAKAELRSKE 900
VKLNLTSLPT PRERFRKIAQ DALSRRIGID IQRARMPPMP VNPAYRPPVP 950
LPSFDPADDR APDLAAIAAA HPPPLPPGMP SHMMPNMPPP FPPRPPFGPP 1000
MLPPGQMRAL GQQAGQALRG QGTALGPQTG QQPMPAQPRG PLTGQAAGTG 1050
VAGQTGQQPS TAGQGTQQGL PGQQRGGVLP GQWPFFPGMP AAQFPPMFNP 1100
QMQRALQMRG QGQIPQRTQG AAAGAGQSRI PQQAG 1135
Length:1,135
Mass (Da):126,661
Last modified:March 21, 2012 - v1
Checksum:i208E25A2E93AA61E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE610383 mRNA. Translation: CCE46157.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE610383 mRNA. Translation: CCE46157.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00349 .

Family and domain databases

Gene3Di 2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Transcriptome and proteome analysis of Pinctada margaritifera calcifying mantle and shell: focus on biomineralization."
    Joubert C., Piquemal D., Marie B., Manchon L., Pierrat F., Zanella-Cleon I., Cochennec-Laureau N., Gueguen Y., Montagnani C.
    BMC Genomics 11:613-613(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
    Tissue: Mantle.
  2. "Different secretory repertoires control the biomineralization processes of prism and nacre deposition of the pearl oyster shell."
    Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C., Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.
    Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 259-266, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Shell.

Entry informationi

Entry nameiHEX_PINMG
AccessioniPrimary (citable) accession number: H2A0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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