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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Shewanella frigidimarina
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (AWJ07_14945)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Multifunctional fusion protein (trpC)
  4. Multifunctional fusion protein (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton acceptorUniRule annotation1
Active sitei61Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotationSAAS annotation (EC:4.2.1.20UniRule annotationSAAS annotation)
Gene namesi
Name:trpAUniRule annotationImported
OrganismiShewanella frigidimarinaImported
Taxonomic identifieri56812 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VNDX-ray2.60A/B/C/D/E/F/G/H1-267[»]
SMRiH1AFK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105F6H. Bacteria.
COG0159. LUCA.

Family and domain databases

CDDicd04724. Tryptophan_synthase_alpha. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
PfamiView protein in Pfam
PF00290. Trp_syntA. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiView protein in PROSITE
PS00167. TRP_SYNTHASE_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

H1AFK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRYQAKFA ALKAQDKGAF VPFVTIGDPS PELSLKIIQT LVDNGADALE
60 70 80 90 100
LGFPFSDPLA DGPVIQGANL RSLAAGTTSS DCFDIITKVR AQHPDMPIGL
110 120 130 140 150
LLYANLVFAN GIDEFYTKAQ AAGVDSVLIA DVPVEESAPF SKAAKAHGIA
160 170 180 190 200
PIFIAPPNAD ADTLKMVSEQ GEGYTYLLSR AGVTGTESKA GEPIENILTQ
210 220 230 240 250
LAEFNAPPPL LGFGIAEPEQ VRAAIKAGAA GAISGSAVVK IIEAHQHDEA
260
TLLAKLAEFT TAMKAAT
Length:267
Mass (Da):27,806
Last modified:March 21, 2012 - v1
Checksum:iFC55FDE6C55A3E40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB690266 Genomic DNA. Translation: BAL45195.1.

Similar proteinsi

Entry informationi

Entry nameiH1AFK5_SHEFR
AccessioniPrimary (citable) accession number: H1AFK5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 27, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources