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Protein

Histone deacetylase

Gene

HDAC3

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Active sitei135Proton acceptorUniRule annotation1
Binding sitei143Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi170Divalent metal cationUniRule annotation1
Metal bindingi172Divalent metal cationUniRule annotation1
Metal bindingi259Divalent metal cationUniRule annotation1
Binding sitei298SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-TGU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:HDAC3Imported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Unplaced

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000015405.

Structurei

3D structure databases

ProteinModelPortaliH0ZXQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 313Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062889.
InParanoidiH0ZXQ4.
OMAiPRAWTHL.
OrthoDBiEOG091G067J.
TreeFamiTF352182.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

H0ZXQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTVDYFYD PDVANFPYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
60 70 80 90 100
YQASQHDMCR FHSEDYIDFL QRVSPNNMQG FTKSLNAFNV GDDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDYYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTYE TSLLVDEPIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PSDLLSYDRT DEPDPEERGS
410 420
EENYNRPEAP NEFYDGDHDN DKESDVEI
Length:428
Mass (Da):48,964
Last modified:February 22, 2012 - v1
Checksum:iC7F30DE3EFD31180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01061867 Genomic DNA. No translation available.
ABQF01061868 Genomic DNA. No translation available.
ABQF01061869 Genomic DNA. No translation available.
ABQF01061870 Genomic DNA. No translation available.
ABQF01061871 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSTGUT00000015661; ENSTGUP00000015405; ENSTGUG00000015013.

Similar proteinsi

Entry informationi

Entry nameiH0ZXQ4_TAEGU
AccessioniPrimary (citable) accession number: H0ZXQ4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: August 30, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported