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H0ZXQ4

- H0ZXQ4_TAEGU

UniProt

H0ZXQ4 - H0ZXQ4_TAEGU

Protein

Histone deacetylase

Gene

HDAC3

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. circadian regulation of gene expression Source: Ensembl
    2. negative regulation of JNK cascade Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of mitotic cell cycle Source: Ensembl
    5. regulation of multicellular organism growth Source: Ensembl
    6. spindle assembly Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_178261. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_178262. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_178837. NOTCH1 Intracellular Domain Regulates Transcription.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    Name:HDAC3Imported
    OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
    Taxonomic identifieri59729 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
    ProteomesiUP000007754: Unplaced

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. spindle microtubule Source: Ensembl
    3. transcriptional repressor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH0ZXQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000062889.
    KOiK11404.
    OMAiNFHYGPG.
    OrthoDBiEOG7DNNTW.
    TreeFamiTF352182.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    H0ZXQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTVDYFYD PDVANFPYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP    50
    YQASQHDMCR FHSEDYIDFL QRVSPNNMQG FTKSLNAFNV GDDCPVFPGL 100
    FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
    VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
    PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDYYQPT 250
    CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
    RNVARCWTYE TSLLVDEPIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
    SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PSDLLSYDRT DEPDPEERGS 400
    EENYNRPEAP NEFYDGDHDN DKESDVEI 428
    Length:428
    Mass (Da):48,964
    Last modified:February 22, 2012 - v1
    Checksum:iC7F30DE3EFD31180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABQF01061867 Genomic DNA. No translation available.
    ABQF01061868 Genomic DNA. No translation available.
    ABQF01061869 Genomic DNA. No translation available.
    ABQF01061870 Genomic DNA. No translation available.
    ABQF01061871 Genomic DNA. No translation available.
    RefSeqiXP_002189056.1. XM_002189020.2.

    Genome annotation databases

    EnsembliENSTGUT00000015661; ENSTGUP00000015405; ENSTGUG00000015013.
    GeneIDi100222558.
    KEGGitgu:100222558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABQF01061867 Genomic DNA. No translation available.
    ABQF01061868 Genomic DNA. No translation available.
    ABQF01061869 Genomic DNA. No translation available.
    ABQF01061870 Genomic DNA. No translation available.
    ABQF01061871 Genomic DNA. No translation available.
    RefSeqi XP_002189056.1. XM_002189020.2.

    3D structure databases

    ProteinModelPortali H0ZXQ4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSTGUT00000015661 ; ENSTGUP00000015405 ; ENSTGUG00000015013 .
    GeneIDi 100222558.
    KEGGi tgu:100222558.

    Organism-specific databases

    CTDi 8841.

    Phylogenomic databases

    GeneTreei ENSGT00530000062889.
    KOi K11404.
    OMAi NFHYGPG.
    OrthoDBi EOG7DNNTW.
    TreeFami TF352182.

    Enzyme and pathway databases

    Reactomei REACT_178261. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_178262. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_178837. NOTCH1 Intracellular Domain Regulates Transcription.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of a songbird."
      Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., Velho T.A.
      , Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.
      Nature 464:757-762(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JAN-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiH0ZXQ4_TAEGU
    AccessioniPrimary (citable) accession number: H0ZXQ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3