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H0ZXQ4

- H0ZXQ4_TAEGU

UniProt

H0ZXQ4 - H0ZXQ4_TAEGU

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Protein

Histone deacetylase

Gene

HDAC3

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. circadian regulation of gene expression Source: Ensembl
  2. negative regulation of JNK cascade Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. regulation of mitotic cell cycle Source: Ensembl
  5. regulation of multicellular organism growth Source: Ensembl
  6. spindle assembly Source: Ensembl
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_178261. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_178262. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_178837. NOTCH1 Intracellular Domain Regulates Transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:HDAC3Imported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
ProteomesiUP000007754: Unplaced

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. spindle microtubule Source: Ensembl
  3. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH0ZXQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000062889.
InParanoidiH0ZXQ4.
KOiK11404.
OMAiNFHYGPG.
OrthoDBiEOG7DNNTW.
TreeFamiTF352182.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

H0ZXQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTVDYFYD PDVANFPYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
60 70 80 90 100
YQASQHDMCR FHSEDYIDFL QRVSPNNMQG FTKSLNAFNV GDDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDYYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTYE TSLLVDEPIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PSDLLSYDRT DEPDPEERGS
410 420
EENYNRPEAP NEFYDGDHDN DKESDVEI
Length:428
Mass (Da):48,964
Last modified:February 22, 2012 - v1
Checksum:iC7F30DE3EFD31180
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABQF01061867 Genomic DNA. No translation available.
ABQF01061868 Genomic DNA. No translation available.
ABQF01061869 Genomic DNA. No translation available.
ABQF01061870 Genomic DNA. No translation available.
ABQF01061871 Genomic DNA. No translation available.
RefSeqiXP_002189056.1. XM_002189020.2.

Genome annotation databases

EnsembliENSTGUT00000015661; ENSTGUP00000015405; ENSTGUG00000015013.
GeneIDi100222558.
KEGGitgu:100222558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABQF01061867 Genomic DNA. No translation available.
ABQF01061868 Genomic DNA. No translation available.
ABQF01061869 Genomic DNA. No translation available.
ABQF01061870 Genomic DNA. No translation available.
ABQF01061871 Genomic DNA. No translation available.
RefSeqi XP_002189056.1. XM_002189020.2.

3D structure databases

ProteinModelPortali H0ZXQ4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSTGUT00000015661 ; ENSTGUP00000015405 ; ENSTGUG00000015013 .
GeneIDi 100222558.
KEGGi tgu:100222558.

Organism-specific databases

CTDi 8841.

Phylogenomic databases

GeneTreei ENSGT00530000062889.
InParanoidi H0ZXQ4.
KOi K11404.
OMAi NFHYGPG.
OrthoDBi EOG7DNNTW.
TreeFami TF352182.

Enzyme and pathway databases

Reactomei REACT_178261. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_178262. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_178837. NOTCH1 Intracellular Domain Regulates Transcription.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of a songbird."
    Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., Velho T.A.
    , Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.
    Nature 464:757-762(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH0ZXQ4_TAEGU
AccessioniPrimary (citable) accession number: H0ZXQ4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3