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Protein
Submitted name:

Calcium sensing receptor

Gene

CASR

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-TGU-416476. G alpha (q) signalling events.
R-TGU-418594. G alpha (i) signalling events.
R-TGU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium sensing receptorImported
Gene namesi
Name:CASRImported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei611 – 633HelicalSequence analysisAdd BLAST23
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Transmembranei681 – 703HelicalSequence analysisAdd BLAST23
Transmembranei724 – 743HelicalSequence analysisAdd BLAST20
Transmembranei769 – 791HelicalSequence analysisAdd BLAST23
Transmembranei803 – 825HelicalSequence analysisAdd BLAST23
Transmembranei831 – 853HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500354759320 – 994Sequence analysisAdd BLAST975

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000013740.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini611 – 875G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST265

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
InParanoidiH0ZSZ4.
OMAiGYTCLLA.
OrthoDBiEOG091G01NA.
TreeFamiTF331269.

Family and domain databases

Gene3Di2.10.50.30. 1 hit.
InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR038550. GPCR_3_9-Cys_sf.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

H0ZSZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYSCCLIL LLFTWSTVAY GPNQRAQKKG DIILGGLFPI HFGVAAKDQD
60 70 80 90 100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPTLLPN MTLGYRIFDT
110 120 130 140 150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGIS
160 170 180 190 200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI
210 220 230 240 250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE
260 270 280 290 300
EIQQVVEVIQ NSTARVIVVF SSGPDLEPLI KEIVRRNITG KIWLASEAWA
310 320 330 340 350
SSSLIAMPEF FRVIGSTIGF ALKAGQIPGF REFLQKVHPK KSTNNGFAKE
360 370 380 390 400
FWEETFNCYL PDGSKSSPAS TSFHKGHEEG LGAGNGTSAF RPPCTGDENI
410 420 430 440 450
TSVETPYMDY THLRISYNVY LAVYSIAHAL QDIYTCTPGK GLFTNGSCAD
460 470 480 490 500
IKKVEAWQVL KHLRHLNFTN NMGEQVDFDE FGDLVGNYSI INWHLSPEDG
510 520 530 540 550
SVVFEEVGHY NVYAKKGERL FINENKILWG GFSKEVPFSN CSRDCLPGTR
560 570 580 590 600
KGIIEGEPTC CFECVDCPDG EYSDETDASA CDKCPEDYWS NENHTSCIPK
610 620 630 640 650
QIEFLAWTEP FGIALTLFAV LGIFLTSFVL GVFTKFRNTP IVKATNRELS
660 670 680 690 700
YLLLFSLLCC FSSSLFFIGE PQNWTCRLRQ PAFGISFVLC ISCILVKTNR
710 720 730 740 750
VLLVFEAKIP TSLHRKWWGL NLQFLLVFLC TFVQIVICVI WLYTAPPSSY
760 770 780 790 800
RNHELEDEII FITCHEGSLM ALGFLIGYTC LLAAICFFFA FKSRKLPENF
810 820 830 840 850
NEAKFITFSM LIFFIVWISF IPAYASTYGK FVSAVEVIAI LAASFGLLAC
860 870 880 890 900
IFFNKVYIIL FKPSRNTIEE VRCSTAAHAF KVAARATLRR SNVSRKRSNS
910 920 930 940 950
LGGSTGSTPS SSISSKSNHE DPFPLPACAE RQRQQQRGCK QKVSFGSGTV
960 970 980 990
TLSLSFEEPQ KNAMANRNAK RRNSLEAQNS DDSLMRHRAL LPLQ
Length:994
Mass (Da):111,402
Last modified:February 22, 2012 - v1
Checksum:i6356F6E30473EABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01027489 Genomic DNA. No translation available.
ABQF01027490 Genomic DNA. No translation available.
ABQF01027491 Genomic DNA. No translation available.
ABQF01027492 Genomic DNA. No translation available.
ABQF01027493 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSTGUT00000013898; ENSTGUP00000013740; ENSTGUG00000013348.

Similar proteinsi

Entry informationi

Entry nameiH0ZSZ4_TAEGU
AccessioniPrimary (citable) accession number: H0ZSZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported