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Protein
Submitted name:

Sodium leak channel, non-selective

Gene

NALCN

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-TGU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium leak channel, non-selectiveImported
Gene namesi
Name:NALCNImported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei108 – 127HelicalSequence analysisAdd BLAST20
Transmembranei139 – 158HelicalSequence analysisAdd BLAST20
Transmembranei178 – 195HelicalSequence analysisAdd BLAST18
Transmembranei299 – 322HelicalSequence analysisAdd BLAST24
Transmembranei385 – 406HelicalSequence analysisAdd BLAST22
Transmembranei418 – 446HelicalSequence analysisAdd BLAST29
Transmembranei506 – 528HelicalSequence analysisAdd BLAST23
Transmembranei577 – 601HelicalSequence analysisAdd BLAST25
Transmembranei883 – 907HelicalSequence analysisAdd BLAST25
Transmembranei958 – 976HelicalSequence analysisAdd BLAST19
Transmembranei1019 – 1042HelicalSequence analysisAdd BLAST24
Transmembranei1136 – 1159HelicalSequence analysisAdd BLAST24
Transmembranei1213 – 1233HelicalSequence analysisAdd BLAST21
Transmembranei1239 – 1258HelicalSequence analysisAdd BLAST20
Transmembranei1278 – 1296HelicalSequence analysisAdd BLAST19
Transmembranei1338 – 1360HelicalSequence analysisAdd BLAST23
Transmembranei1425 – 1449HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000011239.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 331Ion_transInterPro annotationAdd BLAST296
Domaini384 – 605Ion_transInterPro annotationAdd BLAST222
Domaini889 – 1164Ion_transInterPro annotationAdd BLAST276
Domaini1211 – 1459Ion_transInterPro annotationAdd BLAST249

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili800 – 829Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
InParanoidiH0ZKW7.
OMAiMLGDSAM.
OrthoDBiEOG091G00F9.
TreeFamiTF312843.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR028823. NALCN.
PANTHERiPTHR10037:SF214. PTHR10037:SF214. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 4 hits.

Sequencei

Sequence statusi: Complete.

H0ZKW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV
60 70 80 90 100
ISVCMNTPKT FEHYPPLQYV TFALDTLLMF LYTAEMIAKM HIRGIVKGDS
110 120 130 140 150
SYVKDRWCVF DGFMVFCLWV SLVLQVFEIA EIVDQMSPWG MLRIPRPLIM
160 170 180 190 200
IRAFRIYFRF ELPRTRITNI LKRSGEQIWS VSIFLLFFLL LYGILGVQMF
210 220 230 240 250
GTFTYHCVTD DTQPGNVTWN NLAIPDTHCS RELEEGYQCP PGFKCMDLED
260 270 280 290 300
LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF
310 320 330 340 350
YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM
360 370 380 390 400
FHEDAAGGWQ LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVAVDVIV
410 420 430 440 450
AASNYYKGEN FKRQYDEFYL AEVAFTVLFD LEALLKIWCL GFTGYISSSL
460 470 480 490 500
HKFELLLVIG TTLHIYPDLY HSQFTYFQVL RVVRLIKISP ALEDFVYKIF
510 520 530 540 550
GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF PRASAFMSMF
560 570 580 590 600
QILTQEGWVD VMDQTLNAVG HMWAPVVAIY FILYHLFATL ILLSLFVAVI
610 620 630 640 650
LDNLELDEDL KKLKQLKQSE ANADTKEKLP LRLRIFEKFP NRPQMVKISK
660 670 680 690 700
LPSDFTVPKI RESFMKQFID RQQQDTSCLL RRLPSASSSS CDHSKRSAIE
710 720 730 740 750
ENRYIDQKLR KSVFSIRARN LLEKETAINK ILRACTRQRM LSGSFEGQPA
760 770 780 790 800
KERSILSVQH HIRQERRSLR HGSNSQRISR GKSLETLTQD HSNTVRYRNA
810 820 830 840 850
QREDSEIKMI QEKKEQAEMK RKVQEEELRE NHPYFDKPLF IVGREHRFRN
860 870 880 890 900
FCRVVVRARF NASKTDPVTG AVKNTKYHQL YDLLGLVTYL DWVMIIVTIC
910 920 930 940 950
SCISMMFESP FRRVMHAPTL QIAEYVFVIF MSIELNLKIM ADGLFFTPTA
960 970 980 990 1000
VIRDFGGVMD IFIYLVSLIF LCWMPQNVPA KSGAQLLMVL RCLRPLRIFK
1010 1020 1030 1040 1050
LVPQMRKVVR ELFSGFKEIF LVSILLLTLM LVFASFGVQL FAGKLAKCND
1060 1070 1080 1090 1100
PHIISREDCH GIFRINVSVS KNLNLKLRPG EKKPGFWVPR VWANPRNFNF
1110 1120 1130 1140 1150
DNVGNAMLAL FEVLSLKGWV EVRDVIIHRV GPIHGIYIHV FVFLGCMIGL
1160 1170 1180 1190 1200
TLFVGVVIAN FNENKGTALL TVDQRRWEDL KSRLKIAQPL HLPPRPDNDG
1210 1220 1230 1240 1250
FRAKMYDITQ HPFFKRTIAV LVLAQSVLLS VKWDAADPVT VPLATMSVVF
1260 1270 1280 1290 1300
TFIFVLEVTM KIIAMSPSGF WQSRRNRYDL LVTSLGVIWV ILHFALLNAY
1310 1320 1330 1340 1350
TYMMGACVIV FRFFSICGKH VTLKMLLLTV VVSMYKSFFI IVGMFLLLLC
1360 1370 1380 1390 1400
YAFAGVVLFG TVKYGENINR HANFSSAGKA ITVLFRIVTG EDWNKIMHDC
1410 1420 1430 1440 1450
MVQPPFCTPD NSTYWKTDCG NYAGALMYFC SFYVIIAYIM LNLLVAIIVE
1460 1470 1480 1490 1500
NFSLFYSTEE DQLLSYNDLR HFQIIWNMVD DKREGVIPTF RVKFLLRLLR
1510 1520 1530 1540 1550
GRLEVDLDKD KLLFKHMCYE MERLHNGGDV TFHDVLSMLS YRSVDIRKSL
1560 1570 1580 1590 1600
QLEELLAREQ LEYTIEEEVA KQTIRMWLKK CLKRIRAKQQ QSCSIIHSLR
1610 1620 1630 1640 1650
ESQQQELSRF LNPPSIETTQ PSEDMNALNQ DNSAQPETSS QQQLLSPTLS
1660 1670 1680 1690 1700
DRGGYRQDTG DAGKPQRKFG QWRLPSAPKP ISHSVSSVNL RFGGRSTMKS
1710 1720 1730 1740
VACKMNPMSD AASCGSEVKK WWTRQLTVES DESGEDLLDI
Length:1,740
Mass (Da):200,542
Last modified:February 22, 2012 - v1
Checksum:iEDE6D5B66075F204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01013249 Genomic DNA. No translation available.
ABQF01013250 Genomic DNA. No translation available.
ABQF01013251 Genomic DNA. No translation available.
ABQF01013252 Genomic DNA. No translation available.
ABQF01013253 Genomic DNA. No translation available.
ABQF01013254 Genomic DNA. No translation available.
ABQF01013255 Genomic DNA. No translation available.
ABQF01013256 Genomic DNA. No translation available.
ABQF01013257 Genomic DNA. No translation available.
ABQF01013258 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSTGUT00000011360; ENSTGUP00000011239; ENSTGUG00000010876.

Similar proteinsi

Entry informationi

Entry nameiH0ZKW7_TAEGU
AccessioniPrimary (citable) accession number: H0ZKW7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 25, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported