ID   H0YNU9_HUMAN            Unreviewed;       383 AA.
AC   H0YNU9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Interactor of little elongation complex ELL subunit 2 {ECO:0000313|Ensembl:ENSP00000454162.1};
GN   Name=ICE2 {ECO:0000313|Ensembl:ENSP00000454162.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454162.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000454162.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0000313|Ensembl:ENSP00000454162.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC087385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001263314.1; NM_001276385.1.
DR   AlphaFoldDB; H0YNU9; -.
DR   MassIVE; H0YNU9; -.
DR   MaxQB; H0YNU9; -.
DR   PeptideAtlas; H0YNU9; -.
DR   ProteomicsDB; 40666; -.
DR   Antibodypedia; 25471; 158 antibodies from 20 providers.
DR   DNASU; 79664; -.
DR   Ensembl; ENST00000561114.5; ENSP00000454162.1; ENSG00000128915.12.
DR   GeneID; 79664; -.
DR   UCSC; uc010bgk.5; human.
DR   CTD; 79664; -.
DR   HGNC; HGNC:29885; ICE2.
DR   VEuPathDB; HostDB:ENSG00000128915; -.
DR   GeneTree; ENSGT00390000006883; -.
DR   OrthoDB; 1368245at2759; -.
DR   BioGRID-ORCS; 79664; 358 hits in 1156 CRISPR screens.
DR   ChiTaRS; ICE2; human.
DR   GenomeRNAi; 79664; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000128915; Expressed in colonic epithelium and 189 other cell types or tissues.
DR   ExpressionAtlas; H0YNU9; baseline and differential.
DR   PANTHER; PTHR14633; LITTLE ELONGATION COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR14633:SF3; LITTLE ELONGATION COMPLEX SUBUNIT 2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:H0YNU9,
KW   ECO:0007829|MaxQB:H0YNU9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ   SEQUENCE   383 AA;  43811 MW;  C715065EDA4797B5 CRC64;
     MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR IGENLNASAS
     SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF SQREQRSYVD LLVKYAKIPA
     NSKAVGINKN DYLQYLDMKK HVNEEVTEFL KFLQNSAKKC AQDYNMLSDD ARLFTEKILR
     ACIEQVKKYS EFYTLHEVTS LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ
     LSKDDIATIE TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE
     QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM MSKNTSVPVS
     AVFMDKPEEF ISEMDVCNAF FFP
//