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Protein
Submitted name:

Bloom syndrome protein

Gene

BLM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Bloom syndrome proteinImported
Gene namesi
Name:BLMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000197299.10
HGNCiHGNC:1058 BLM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197299

PTM / Processingi

Proteomic databases

EPDiH0YNU5
MaxQBiH0YNU5
PeptideAtlasiH0YNU5
PRIDEiH0YNU5

Expressioni

Gene expression databases

BgeeiENSG00000197299
ExpressionAtlasiH0YNU5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YNU5
SMRiH0YNU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 851Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini877 – 1024Helicase C-terminalInterPro annotationAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 279Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00550000074520

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR012532 BDHCT
IPR032439 BDHCT_assoc
IPR032437 BLM_N
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF08072 BDHCT, 1 hit
PF16204 BDHCT_assoc, 1 hit
PF16202 BLM_N, 1 hit
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

H0YNU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT
60 70 80 90 100
NVSVAKTPVL RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ
110 120 130 140 150
RGGSKSLLPD FLQTPKEVVC TTQNTPTVKK SRDTALKKLE FSSSPDSLST
160 170 180 190 200
INDWDDMDDF DTSETSKSFV TPPQSHFVRV STAQKSKKGK RNFFKAQLYT
210 220 230 240 250
TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD GPIAEVHINE
260 270 280 290 300
DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF
310 320 330 340 350
VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM
360 370 380 390 400
QELNPETSTD CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL
410 420 430 440 450
LQQRNIRRKL LTEVDFNKSD ASLLGSLWRY RPDSLDGPME GDSCPTGNSM
460 470 480 490 500
KELNFSHLPS NSVSPGDCLL TTTLGKTGFS ATRKNLFERP LFNTHLQKSF
510 520 530 540 550
VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI NDLERETQPS
560 570 580 590 600
YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL
610 620 630 640 650
SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP
660 670 680 690 700
HTKEMMKIFH KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ
710 720 730 740 750
LPACVSPGVT VVISPLRSLI VDQVQKLTSL DIPATYLTGD KTDSEATNIY
760 770 780 790 800
LQLSKKDPII KLLYVTPEKI CASNRLISTL ENLYERKLLA RFVIDEAHCV
810 820 830 840 850
SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD ILTQLKILRP
860 870 880 890 900
QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE
910 920 930 940 950
CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG
960 970 980 990 1000
MGIDKPDVRF VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR
1010 1020 1030 1040 1050
LKRLIMMEKD GNHHTRETHF NNLYSMVHYC ENITECRRIQ LLAYFGENGF
1060 1070 1080 1090 1100
NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD VKSIVRFVQE HSSSQGMRNI
1110 1120 1130 1140 1150
KHVGPSGRFT MNMLVDIFLE SLSSDPEVLL QIDGVTEDKL EKYGAEVISV
1160 1170 1180 1190 1200
LQKYSEWTSP AEDSSPGISL SSSRGPGRSA AEELDEEIPV SSHYFASKTR
1210 1220 1230 1240 1250
NERKRKKMPA SQRSKRRKTA SSGSKAKGGS ATCRKISSKT KSSSIIGSSS
1260 1270 1280
ASHTSQATSG ANSKLGIMAP PKPINRPFLK PSYAFS
Length:1,286
Mass (Da):144,472
Last modified:February 22, 2012 - v1
Checksum:iECFA21B0D535FA58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021422 Genomic DNA No translation available.
AC124248 Genomic DNA No translation available.
KF511223 Genomic DNA No translation available.
RefSeqiNP_001274176.1, NM_001287247.1
UniGeneiHs.725208

Genome annotation databases

EnsembliENST00000560509; ENSP00000454158; ENSG00000197299
GeneIDi641
UCSCiuc010bnx.5 human

Similar proteinsi

Entry informationi

Entry nameiH0YNU5_HUMAN
AccessioniPrimary (citable) accession number: H0YNU5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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