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Protein
Submitted name:

Tyrosine-protein kinase receptor TYRO3

Gene

TYRO3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase receptor TYRO3Imported
Gene namesi
Name:TYRO3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:12446. TYRO3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei384 – 406HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092445.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiH0YNK6.
PaxDbiH0YNK6.
PeptideAtlasiH0YNK6.
PRIDEiH0YNK6.

Expressioni

Gene expression databases

BgeeiENSG00000092445.
ExpressionAtlasiH0YNK6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263798.

Structurei

3D structure databases

ProteinModelPortaliH0YNK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 83Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST83
Domaini94 – 175Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST82
Domaini182 – 275Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini280 – 371Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini473 – 745Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H0YNK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPVKLTVS QGQPVKLNCS VEGMEEPDIQ WVKDGAVVQN LDQLYIPVSE
60 70 80 90 100
QHWIGFLSLK SVERSDAGRY WCQVEDGGET EISQPVWLTV EGVPFFTVEP
110 120 130 140 150
KDLAVPPNAP FQLSCEAVGP PEPVTIVWWR GTTKIGGPAP SPSVLNVTGV
160 170 180 190 200
TQSTMFSCEA HNLKGLASSR TATVHLQALP AAPFNITVTK LSSSNASVAW
210 220 230 240 250
MPGADGRALL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL RDLVPATNYS
260 270 280 290 300
LRVRCANALG PSPYADWVPF QTKGLAPASA PQNLHAIRTD SGLILEWEEV
310 320 330 340 350
IPEAPLEGPL GPYKLSWVQD NGTQDELTVE GTRANLTGWD PQKDLIVRVC
360 370 380 390 400
VSNAVGCGPW SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG VLTALVTAAA
410 420 430 440 450
LALILLRKRR KETRFGQAFD SVMARGEPAV HFRAARSFNR ERPERIEATL
460 470 480 490 500
DSLGISDELK EKLEDVLIPE QQFTLGRMLG KGEFGSVREA QLKQEDGSFV
510 520 530 540 550
KVAVKMLKAD IIASSDIEEF LREAACMKEF DHPHVAKLVG VSLRSRAKGR
560 570 580 590 600
LPIPMVILPF MKHGDLHAFL LASRIGENPF NLPLQTLIRF MVDIACGMEY
610 620 630 640 650
LSSRNFIHRD LAARNCMLAE DMTVCVADFG LSRKIYSGDY YRQGCASKLP
660 670 680 690 700
VKWLALESLA DNLYTVQSDV WAFGVTMWEI MTRGQTPYAG IENAEIYNYL
710 720 730 740 750
IGGNRLKQPP ECMEDVYDLM YQCWSADPKQ RPSFTCLRME LENILGQLSV
760 770 780 790 800
LSASQDPLYI NIERAEEPTA GGSLELPGRD QPYSGAGDGS GMGAVGGTPS
810 820 830 840
DCRYILTPGG LAEQPGQAEH QPESPLNETQ RLLLLQQGLL PHSSC
Length:845
Mass (Da):92,316
Last modified:February 22, 2012 - v1
Checksum:i01C6CE9367B8BCCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016134 Genomic DNA. No translation available.
RefSeqiNP_001317193.1. NM_001330264.1.
UniGeneiHs.381282.

Genome annotation databases

EnsembliENST00000559066; ENSP00000454050; ENSG00000092445.
GeneIDi7301.
UCSCiuc059hzf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016134 Genomic DNA. No translation available.
RefSeqiNP_001317193.1. NM_001330264.1.
UniGeneiHs.381282.

3D structure databases

ProteinModelPortaliH0YNK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263798.

Proteomic databases

MaxQBiH0YNK6.
PaxDbiH0YNK6.
PeptideAtlasiH0YNK6.
PRIDEiH0YNK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000559066; ENSP00000454050; ENSG00000092445.
GeneIDi7301.
UCSCiuc059hzf.1. human.

Organism-specific databases

CTDi7301.
HGNCiHGNC:12446. TYRO3.
OpenTargetsiENSG00000092445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.

Miscellaneous databases

ChiTaRSiTYRO3. human.
GenomeRNAii7301.

Gene expression databases

BgeeiENSG00000092445.
ExpressionAtlasiH0YNK6. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0YNK6_HUMAN
AccessioniPrimary (citable) accession number: H0YNK6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 30, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.