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Protein
Submitted name:

Tyrosine-protein kinase receptor TYRO3

Gene

TYRO3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase receptor TYRO3Imported
Gene namesi
Name:TYRO3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000092445.11
HGNCiHGNC:12446 TYRO3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei384 – 406HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092445

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

EPDiH0YNK6
MaxQBiH0YNK6
PeptideAtlasiH0YNK6
PRIDEiH0YNK6

Expressioni

Gene expression databases

BgeeiENSG00000092445
ExpressionAtlasiH0YNK6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YNK6
SMRiH0YNK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 83Ig-likeInterPro annotationAdd BLAST83
Domaini94 – 175Ig-likeInterPro annotationAdd BLAST82
Domaini182 – 275Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini280 – 371Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini473 – 745Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG6I Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

H0YNK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPVKLTVS QGQPVKLNCS VEGMEEPDIQ WVKDGAVVQN LDQLYIPVSE
60 70 80 90 100
QHWIGFLSLK SVERSDAGRY WCQVEDGGET EISQPVWLTV EGVPFFTVEP
110 120 130 140 150
KDLAVPPNAP FQLSCEAVGP PEPVTIVWWR GTTKIGGPAP SPSVLNVTGV
160 170 180 190 200
TQSTMFSCEA HNLKGLASSR TATVHLQALP AAPFNITVTK LSSSNASVAW
210 220 230 240 250
MPGADGRALL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL RDLVPATNYS
260 270 280 290 300
LRVRCANALG PSPYADWVPF QTKGLAPASA PQNLHAIRTD SGLILEWEEV
310 320 330 340 350
IPEAPLEGPL GPYKLSWVQD NGTQDELTVE GTRANLTGWD PQKDLIVRVC
360 370 380 390 400
VSNAVGCGPW SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG VLTALVTAAA
410 420 430 440 450
LALILLRKRR KETRFGQAFD SVMARGEPAV HFRAARSFNR ERPERIEATL
460 470 480 490 500
DSLGISDELK EKLEDVLIPE QQFTLGRMLG KGEFGSVREA QLKQEDGSFV
510 520 530 540 550
KVAVKMLKAD IIASSDIEEF LREAACMKEF DHPHVAKLVG VSLRSRAKGR
560 570 580 590 600
LPIPMVILPF MKHGDLHAFL LASRIGENPF NLPLQTLIRF MVDIACGMEY
610 620 630 640 650
LSSRNFIHRD LAARNCMLAE DMTVCVADFG LSRKIYSGDY YRQGCASKLP
660 670 680 690 700
VKWLALESLA DNLYTVQSDV WAFGVTMWEI MTRGQTPYAG IENAEIYNYL
710 720 730 740 750
IGGNRLKQPP ECMEDVYDLM YQCWSADPKQ RPSFTCLRME LENILGQLSV
760 770 780 790 800
LSASQDPLYI NIERAEEPTA GGSLELPGRD QPYSGAGDGS GMGAVGGTPS
810 820 830 840
DCRYILTPGG LAEQPGQAEH QPESPLNETQ RLLLLQQGLL PHSSC
Length:845
Mass (Da):92,316
Last modified:February 22, 2012 - v1
Checksum:i01C6CE9367B8BCCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016134 Genomic DNA No translation available.
RefSeqiNP_001317193.1, NM_001330264.1
UniGeneiHs.381282

Genome annotation databases

EnsembliENST00000559066; ENSP00000454050; ENSG00000092445
GeneIDi7301
UCSCiuc059hzf.1 human

Similar proteinsi

Entry informationi

Entry nameiH0YNK6_HUMAN
AccessioniPrimary (citable) accession number: H0YNK6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health