RORA

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	72 – 147	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Nuclear receptor ROR-alphaImported
Gene namesⁱ	Name:RORAImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

HGNCⁱ

HGNC:10258. RORA.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00407
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00586772

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000069667.

OpenTargetsⁱ

ENSG00000069667.

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	H0YLS5.
PeptideAtlas More...PeptideAtlasⁱ	H0YLS5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000069667.
ExpressionAtlasⁱ	H0YLS5. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000261523.

STRINGⁱ

9606.ENSP00000261523.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	H0YLS5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 147	Nuclear receptor DNA-bindingInterPro annotationAdd BLAST		76

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4216. Eukaryota. ENOG410XUGR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388.

Family and domain databases

Gene3Dⁱ	3.30.50.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00399. ZnF_C4. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

H0YLS5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRVTVAPQTK PVFSTNELAH LSPPSAPASQ RESGVGLRAS CPTEWGQKVV 
        60         70         80         90        100
RGAFRGALRA EKRPAATAQI EIIPCKICGD KSSGIHYGVI TCEGCKGFFR 
       110        120        130        140        150
RSQQSNATYS CPRQKNCLID RTSRNRCQHC RLQKCLAVGM SRDAVKFGRM 

SKK

Length:153

Mass (Da):16,799

Last modified:February 22, 2012 - v1

Checksum:ⁱ5D7973129AD57FC8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	153	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC087385 Genomic DNA. No translation available. AC107241 Genomic DNA. No translation available. KC877548 Genomic DNA. No translation available. KC877551 Genomic DNA. No translation available. KC877555 Genomic DNA. No translation available. KF456062 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
KC877548 Genomic DNA. No translation available.
KC877551 Genomic DNA. No translation available.
KC877555 Genomic DNA. No translation available.
KF456062 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000559343; ENSP00000453322; ENSG00000069667.
UCSC genome browser More...UCSCⁱ	uc059jyl.1. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC087385 Genomic DNA. No translation available. AC107241 Genomic DNA. No translation available. KC877548 Genomic DNA. No translation available. KC877551 Genomic DNA. No translation available. KC877555 Genomic DNA. No translation available. KF456062 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
KC877548 Genomic DNA. No translation available.
KC877551 Genomic DNA. No translation available.
KC877555 Genomic DNA. No translation available.
KF456062 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	H0YLS5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000261523.

STRINGⁱ

9606.ENSP00000261523.

Proteomic databases

PaxDbⁱ	H0YLS5.
PeptideAtlas More...PeptideAtlasⁱ	H0YLS5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000559343; ENSP00000453322; ENSG00000069667.
UCSC genome browser More...UCSCⁱ	uc059jyl.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10258. RORA.
Open Targets More...OpenTargetsⁱ	ENSG00000069667.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4216. Eukaryota. ENOG410XUGR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388.

Miscellaneous databases

ChiTaRSⁱ	RORA. human.

ChiTaRSⁱ

RORA. human.

Gene expression databases

Bgeeⁱ	ENSG00000069667.
ExpressionAtlasⁱ	H0YLS5. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.30.50.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00399. ZnF_C4. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0YLS5_HUMAN
Accessionⁱ	H0YLS5Primary (citable) accession number: H0YLS5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	February 22, 2012
	Last modified:	May 10, 2017
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H0YLS5 (H0YLS5_HUMAN)

Your basket is currently empty.

Nuclear receptor ROR-alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ