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H0YLS5

- H0YLS5_HUMAN

UniProt

H0YLS5 - H0YLS5_HUMAN

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Protein
Submitted name: Nuclear receptor ROR-alpha
Gene
RORA
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor ROR-alphaImported
Gene namesi
Name:RORAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10258. RORA.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiH0YLS5.
BgeeiH0YLS5.

Structurei

3D structure databases

ProteinModelPortaliH0YLS5.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

OMAiQNIISHI.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0YLS5-1 [UniParc]FASTAAdd to Basket

« Hide

MRVTVAPQTK PVFSTNELAH LSPPSAPASQ RESGVGLRAS CPTEWGQKVV    50
RGAFRGALRA EKRPAATAQI EIIPCKICGD KSSGIHYGVI TCEGCKGFFR 100
RSQQSNATYS CPRQKNCLID RTSRNRCQHC RLQKCLAVGM SRDAVKFGRM 150
SKK 153
Length:153
Mass (Da):16,799
Last modified:February 22, 2012 - v1
Checksum:i5D7973129AD57FC8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei153 – 1531Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009560 Genomic DNA. No translation available.
AC012404 Genomic DNA. No translation available.
AC022898 Genomic DNA. No translation available.
AC079068 Genomic DNA. No translation available.
AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
AC107905 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000559343; ENSP00000453322; ENSG00000069667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009560 Genomic DNA. No translation available.
AC012404 Genomic DNA. No translation available.
AC022898 Genomic DNA. No translation available.
AC079068 Genomic DNA. No translation available.
AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
AC107905 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali H0YLS5.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000559343 ; ENSP00000453322 ; ENSG00000069667 .

Organism-specific databases

HGNCi HGNC:10258. RORA.
GenAtlasi Search...

Phylogenomic databases

OMAi QNIISHI.

Miscellaneous databases

ChiTaRSi RORA. human.
NextBioi 35524528.

Gene expression databases

ArrayExpressi H0YLS5.
Bgeei H0YLS5.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH0YLS5_HUMAN
AccessioniPrimary (citable) accession number: H0YLS5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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