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H0YLS5

- H0YLS5_HUMAN

UniProt

H0YLS5 - H0YLS5_HUMAN

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Protein
Submitted name:

Nuclear receptor ROR-alpha

Gene

RORA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor ROR-alphaImported
Gene namesi
Name:RORAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10258. RORA.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiH0YLS5.
ExpressionAtlasiH0YLS5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0YLS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119049.
OMAiQNIISHI.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0YLS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTVAPQTK PVFSTNELAH LSPPSAPASQ RESGVGLRAS CPTEWGQKVV
60 70 80 90 100
RGAFRGALRA EKRPAATAQI EIIPCKICGD KSSGIHYGVI TCEGCKGFFR
110 120 130 140 150
RSQQSNATYS CPRQKNCLID RTSRNRCQHC RLQKCLAVGM SRDAVKFGRM

SKK
Length:153
Mass (Da):16,799
Last modified:February 22, 2012 - v1
Checksum:i5D7973129AD57FC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei153 – 1531Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009560 Genomic DNA. No translation available.
AC012404 Genomic DNA. No translation available.
AC022898 Genomic DNA. No translation available.
AC079068 Genomic DNA. No translation available.
AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
AC107905 Genomic DNA. No translation available.
KC877546 Genomic DNA. No translation available.
KC877548 Genomic DNA. No translation available.
KC877551 Genomic DNA. No translation available.
KC877553 Genomic DNA. No translation available.
KC877555 Genomic DNA. No translation available.
KC877558 Genomic DNA. No translation available.
KC877560 Genomic DNA. No translation available.
KC877561 Genomic DNA. No translation available.
KC877563 Genomic DNA. No translation available.
KC877565 Genomic DNA. No translation available.
KC877566 Genomic DNA. No translation available.
KF454895 Genomic DNA. No translation available.
KF456062 Genomic DNA. No translation available.
KF456065 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000559343; ENSP00000453322; ENSG00000069667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009560 Genomic DNA. No translation available.
AC012404 Genomic DNA. No translation available.
AC022898 Genomic DNA. No translation available.
AC079068 Genomic DNA. No translation available.
AC087385 Genomic DNA. No translation available.
AC107241 Genomic DNA. No translation available.
AC107905 Genomic DNA. No translation available.
KC877546 Genomic DNA. No translation available.
KC877548 Genomic DNA. No translation available.
KC877551 Genomic DNA. No translation available.
KC877553 Genomic DNA. No translation available.
KC877555 Genomic DNA. No translation available.
KC877558 Genomic DNA. No translation available.
KC877560 Genomic DNA. No translation available.
KC877561 Genomic DNA. No translation available.
KC877563 Genomic DNA. No translation available.
KC877565 Genomic DNA. No translation available.
KC877566 Genomic DNA. No translation available.
KF454895 Genomic DNA. No translation available.
KF456062 Genomic DNA. No translation available.
KF456065 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali H0YLS5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000559343 ; ENSP00000453322 ; ENSG00000069667 .

Organism-specific databases

HGNCi HGNC:10258. RORA.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119049.
OMAi QNIISHI.

Miscellaneous databases

ChiTaRSi RORA. human.
NextBioi 35524528.

Gene expression databases

Bgeei H0YLS5.
ExpressionAtlasi H0YLS5. baseline and differential.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH0YLS5_HUMAN
AccessioniPrimary (citable) accession number: H0YLS5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3