H0YLS5 (H0YLS5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nuclear receptor ROR-alpha Ensembl ENSP00000453322

Gene names

Name:

RORA Ensembl ENSP00000453322

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000453322

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains nuclear receptor DNA-binding domain. SAAS SAAS001628
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000453322

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001628
Cellular component	Nucleus SAAS SAAS001628
Domain	Zinc-finger SAAS SAAS001628
Ligand	DNA-binding SAAS SAAS001628 Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: GOC transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	153	1	Ensembl ENSP00000453322

Sequences

	Sequence		Length	Mass (Da)
	H0YLS5 [UniParc]. Last modified February 22, 2012. Version 1. Checksum: 5D7973129AD57FC8	FASTA	153	16,799
	10 20 30 40 50 60 MRVTVAPQTK PVFSTNELAH LSPPSAPASQ RESGVGLRAS CPTEWGQKVV RGAFRGALRA 70 80 90 100 110 120 EKRPAATAQI EIIPCKICGD KSSGIHYGVI TCEGCKGFFR RSQQSNATYS CPRQKNCLID 130 140 150 RTSRNRCQHC RLQKCLAVGM SRDAVKFGRM SKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JAN-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009560 Genomic DNA. No translation available. AC012404 Genomic DNA. No translation available. AC022898 Genomic DNA. No translation available. AC079068 Genomic DNA. No translation available. AC087385 Genomic DNA. No translation available. AC107241 Genomic DNA. No translation available. AC107905 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	H0YLS5.
ModBase	Search...
MobiDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000559343; ENSP00000453322; ENSG00000069667.
Organism-specific databases
HGNC	HGNC:10258. RORA.
GenAtlas	Search...
Gene expression databases
Bgee	H0YLS5.
Family and domain databases
Gene3D	1.10.565.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR001628. Znf_hrmn_rcpt. [Graphical view]
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RORA. human.
NextBio	35524528.

Entry information

Entry name

H0YLS5_HUMAN

Accession

Primary (citable) accession number: H0YLS5

Entry history

Integrated into UniProtKB/TrEMBL:	February 22, 2012
Last sequence update:	February 22, 2012
Last modified:	February 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.