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H0YLS5

- H0YLS5_HUMAN

UniProt

H0YLS5 - H0YLS5_HUMAN

Protein
Submitted name:

Nuclear receptor ROR-alpha

Gene

RORA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
  1. Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear receptor ROR-alphaImported
    Gene namesi
    Name:RORAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10258. RORA.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiH0YLS5.
    BgeeiH0YLS5.

    Structurei

    3D structure databases

    ProteinModelPortaliH0YLS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    OMAiQNIISHI.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    [Graphical view]
    PfamiPF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    H0YLS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVTVAPQTK PVFSTNELAH LSPPSAPASQ RESGVGLRAS CPTEWGQKVV    50
    RGAFRGALRA EKRPAATAQI EIIPCKICGD KSSGIHYGVI TCEGCKGFFR 100
    RSQQSNATYS CPRQKNCLID RTSRNRCQHC RLQKCLAVGM SRDAVKFGRM 150
    SKK 153
    Length:153
    Mass (Da):16,799
    Last modified:February 22, 2012 - v1
    Checksum:i5D7973129AD57FC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei153 – 1531Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009560 Genomic DNA. No translation available.
    AC012404 Genomic DNA. No translation available.
    AC022898 Genomic DNA. No translation available.
    AC079068 Genomic DNA. No translation available.
    AC087385 Genomic DNA. No translation available.
    AC107241 Genomic DNA. No translation available.
    AC107905 Genomic DNA. No translation available.
    KC877546 Genomic DNA. No translation available.
    KC877548 Genomic DNA. No translation available.
    KC877551 Genomic DNA. No translation available.
    KC877553 Genomic DNA. No translation available.
    KC877555 Genomic DNA. No translation available.
    KC877558 Genomic DNA. No translation available.
    KC877560 Genomic DNA. No translation available.
    KC877561 Genomic DNA. No translation available.
    KC877563 Genomic DNA. No translation available.
    KC877565 Genomic DNA. No translation available.
    KC877566 Genomic DNA. No translation available.
    KF454895 Genomic DNA. No translation available.
    KF456062 Genomic DNA. No translation available.
    KF456065 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000559343; ENSP00000453322; ENSG00000069667.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009560 Genomic DNA. No translation available.
    AC012404 Genomic DNA. No translation available.
    AC022898 Genomic DNA. No translation available.
    AC079068 Genomic DNA. No translation available.
    AC087385 Genomic DNA. No translation available.
    AC107241 Genomic DNA. No translation available.
    AC107905 Genomic DNA. No translation available.
    KC877546 Genomic DNA. No translation available.
    KC877548 Genomic DNA. No translation available.
    KC877551 Genomic DNA. No translation available.
    KC877553 Genomic DNA. No translation available.
    KC877555 Genomic DNA. No translation available.
    KC877558 Genomic DNA. No translation available.
    KC877560 Genomic DNA. No translation available.
    KC877561 Genomic DNA. No translation available.
    KC877563 Genomic DNA. No translation available.
    KC877565 Genomic DNA. No translation available.
    KC877566 Genomic DNA. No translation available.
    KF454895 Genomic DNA. No translation available.
    KF456062 Genomic DNA. No translation available.
    KF456065 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali H0YLS5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000559343 ; ENSP00000453322 ; ENSG00000069667 .

    Organism-specific databases

    HGNCi HGNC:10258. RORA.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi QNIISHI.

    Miscellaneous databases

    ChiTaRSi RORA. human.
    NextBioi 35524528.

    Gene expression databases

    ArrayExpressi H0YLS5.
    Bgeei H0YLS5.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    [Graphical view ]
    Pfami PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JAN-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiH0YLS5_HUMAN
    AccessioniPrimary (citable) accession number: H0YLS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3