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Protein
Submitted name:

Transient receptor potential cation channel subfamily M member 7

Gene

TRPM7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel subfamily M member 7Imported
Submitted name:
Transient receptor potential cation channel, subfamily M, member 7, isoform CRA_cImported
Gene namesi
Name:TRPM7Imported
ORF Names:hCG_39859Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17994. TRPM7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei758 – 776HelicalSequence analysisAdd BLAST19
Transmembranei856 – 878HelicalSequence analysisAdd BLAST23
Transmembranei923 – 945HelicalSequence analysisAdd BLAST23
Transmembranei957 – 976HelicalSequence analysisAdd BLAST20
Transmembranei997 – 1016HelicalSequence analysisAdd BLAST20
Transmembranei1078 – 1101HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092439.

PTM / Processingi

Proteomic databases

MaxQBiH0YLN8.
PeptideAtlasiH0YLN8.
PRIDEiH0YLN8.

Expressioni

Gene expression databases

BgeeiENSG00000092439.
ExpressionAtlasiH0YLN8. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiH0YLN8. 10 interactors.
STRINGi9606.ENSP00000320239.

Structurei

3D structure databases

ProteinModelPortaliH0YLN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1593 – 1823Alpha-type protein kinaseInterPro annotationAdd BLAST231

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029601. TRPM7.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF8. PTHR13800:SF8. 3 hits.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H0YLN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ
60 70 80 90 100
HACFTASLAM KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG
110 120 130 140 150
SHSYRAKYVR LSYDTKPEVI LQLLLKEWQM ELPKLVISVH GGMQKFELHP
160 170 180 190 200
RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC
210 220 230 240 250
TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN LHSHFILVDD
260 270 280 290 300
GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV
310 320 330 340 350
LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI
360 370 380 390 400
KKTFNFGQNE ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL
410 420 430 440 450
KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD
460 470 480 490 500
RVAFVKLLIE NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLVRDVKQGN
510 520 530 540 550
LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN
560 570 580 590 600
TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK
610 620 630 640 650
KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA
660 670 680 690 700
KALVACKIYR SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ
710 720 730 740 750
DETMAMKLLT YELKNWSNST CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR
760 770 780 790 800
LNMRKNSWYK VILSILVPPA ILLLEYKTKA EMSHIPQSQD AHQMTMDDSE
810 820 830 840 850
NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP ITRKFYAFYH
860 870 880 890 900
APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK
910 920 930 940 950
VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA
960 970 980 990 1000
NAYDNHVFVA GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM
1010 1020 1030 1040 1050
FYIVVIMALV LLSFGVPRKA ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA
1060 1070 1080 1090 1100
YEIDVCANDS VIPQICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY
1110 1120 1130 1140 1150
LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS LFCCICKRRK
1160 1170 1180 1190 1200
KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT
1210 1220 1230 1240 1250
FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT
1260 1270 1280 1290 1300
AQKASEASKV HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS
1310 1320 1330 1340 1350
SLPQGDLESN NPFHCNILMK DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS
1360 1370 1380 1390 1400
SSGALFPSAV SPPELRQRLH GVELLKIFNK NQKLGSSSTS IPHLSSPPTK
1410 1420 1430 1440 1450
FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF VGHRDSMDLQ
1460 1470 1480 1490 1500
RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQEKISR
1510 1520 1530 1540 1550
RPSTEDTHEV DSKAALIPDW LQDRPSNREM PSEEGTLNGL TSPFKPAMDT
1560 1570 1580 1590 1600
NYYYSAVERN NLMRLSQSIP FTPVPPRGEP VTVYRLEESS PNILNNSMSS
1610 1620 1630 1640 1650
WSQLGLCAKI EFLSKEEMGG GLRRAVKVQC TWSEHDILKS GHLYIIKSFL
1660 1670 1680 1690 1700
PEVVNTWSSI YKEDTVLHLC LREIQQQRAA QKLTFAFNQM KPKSIPYSPR
1710 1720 1730 1740 1750
FLEVFLLYCH SAGQWFAVEE CMTGEFRKYN NNNGDEIIPT NTLEEIMLAF
1760 1770 1780 1790 1800
SHWTYEYTRG ELLVLDLQGV GENLTDPSVI KAEEKRSCDM VFGPANLGED
1810 1820 1830 1840 1850
AIKNFRAKHH CNSCCRKLKL PDLKRNDYTP DKIIFPQDEP SDLNLQPGNS
1860
TKESESTNSV RLML
Length:1,864
Mass (Da):212,626
Last modified:February 22, 2012 - v1
Checksum:iE3D1312F9536EED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084756 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77407.1.
RefSeqiNP_001288141.1. NM_001301212.1.
UniGeneiHs.512894.

Genome annotation databases

EnsembliENST00000560955; ENSP00000453277; ENSG00000092439.
GeneIDi54822.
UCSCiuc059jee.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084756 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77407.1.
RefSeqiNP_001288141.1. NM_001301212.1.
UniGeneiHs.512894.

3D structure databases

ProteinModelPortaliH0YLN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH0YLN8. 10 interactors.
STRINGi9606.ENSP00000320239.

Proteomic databases

MaxQBiH0YLN8.
PeptideAtlasiH0YLN8.
PRIDEiH0YLN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000560955; ENSP00000453277; ENSG00000092439.
GeneIDi54822.
UCSCiuc059jee.1. human.

Organism-specific databases

CTDi54822.
HGNCiHGNC:17994. TRPM7.
OpenTargetsiENSG00000092439.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.

Miscellaneous databases

ChiTaRSiTRPM7. human.
GenomeRNAii54822.

Gene expression databases

BgeeiENSG00000092439.
ExpressionAtlasiH0YLN8. baseline and differential.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029601. TRPM7.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF8. PTHR13800:SF8. 3 hits.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0YLN8_HUMAN
AccessioniPrimary (citable) accession number: H0YLN8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 30, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.