H0YLB5 (H0YLB5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
POU domain, class 2, transcription factor 1 Ensembl ENSP00000453135

Gene names

Name:

POU2F1 Ensembl ENSP00000453135

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000453135

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Sequence similarities	Contains 1 POU-specific domain. Contains 1 homeobox DNA-binding domain. SAAS SAAS013847
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000453135

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682 SAAS SAAS013847
Domain	Homeobox SAAS SAAS013847 RuleBase RU000682
Ligand	DNA-binding RuleBase RU000682 SAAS SAAS013847
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H0YLB5 [UniParc]. Last modified February 22, 2012. Version 1. Checksum: 9FE411AAACFD42EC	FASTA	528	56,252
	10 20 30 40 50 60 MADGGAASQD ESSAAAAAAA DSRMNNPSET SKPSMESGDG NTGTQTNGLD FQKQPVPVGG 70 80 90 100 110 120 AISTAQAQAF LGHLHQVQLA GTSLQAAAQS LNVQSKSNEE SGDSQQPSQP SQQPSVQAAI 130 140 150 160 170 180 PQTQLMLAGG QITGLTLTPA QQQLLLQQAQ AQAQLLAAAV QQHSASQQHS AAGATISASA 190 200 210 220 230 240 ATPMTQIPLS QPIQIAQDLQ QLQQLQQQNL NLQQFVLVHP TTNLQPAQFI ISQTPQGQQG 250 260 270 280 290 300 LLQAQNLLTQ LPQQSQANLL QSQPSITLTS QPATPTRTIA ATPIQTLPQS QSTPKRIDTP 310 320 330 340 350 360 SLEEPSDLEE LEQFAKTFKQ RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK 370 380 390 400 410 420 NMCKLKPLLE KWLNDAENLS SDSSLSSPSA LNSPGIEGLS RRRKKRTSIE TNIRVALEKS 430 440 450 460 470 480 FLENQKPTSE EITMIADQLN MEKEVIRVWF CNRRQKEKRI NPPSSGGTSS SPIKAIFPSP 490 500 510 520 TSLVATTPSL VTSSAATTLT VSPVLPLTSA AVTNLSALQT PPPTTQQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JAN-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136984 Genomic DNA. No translation available. AL359962 Genomic DNA. No translation available. AL451050 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	H0YLB5.
SMR	H0YLB5. Positions 305-461.
ModBase	Search...
Proteomic databases
PRIDE	H0YLB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000558944; ENSP00000453135; ENSG00000143190.
Organism-specific databases
HGNC	HGNC:9212. POU2F1.
GenAtlas	Search...
Gene expression databases
ArrayExpress	H0YLB5.
Bgee	H0YLB5.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 1.10.260.40. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR000327. POU_specific. IPR000972. TF_octamer. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PRINTS	PR00029. OCTAMER. PR00028. POUDOMAIN.
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	POU2F1. human.
NextBio	35524393.

Entry information

Entry name

H0YLB5_HUMAN

Accession

Primary (citable) accession number: H0YLB5

Entry history

Integrated into UniProtKB/TrEMBL:	February 22, 2012
Last sequence update:	February 22, 2012
Last modified:	April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.