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Protein

Transmembrane protein 250

Gene

TMEM250

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation by promoting progression into S phase.1 Publication
(Microbial infection) Promotes human herpesvirus 1 (HHV-1) proliferation.1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of viral process Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 250Imported
Alternative name(s):
Herpes virus UL25-binding protein1 Publication
Gene namesi
Name:TMEM250Imported
Synonyms:C9orf69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000238227.7.
HGNCiHGNC:31009. TMEM250.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000238227.

Polymorphism and mutation databases

BioMutaiC9orf69.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004209061 – 139Transmembrane protein 250Add BLAST139

Proteomic databases

MaxQBiH0YL14.
PaxDbiH0YL14.
PRIDEiH0YL14.

Expressioni

Inductioni

Up-regulated upon HHV-1 infection.1 Publication

Gene expression databases

BgeeiENSG00000238227.
ExpressionAtlasiH0YL14. baseline and differential.
GenevisibleiH0YL14. HS.

Organism-specific databases

HPAiHPA066070.

Interactioni

Subunit structurei

Interacts with HHV-1 protein CVC2/UL25; this interaction occurs in the course of a HHV-1 infection.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UL25D3YP883EBI-6399705,EBI-6449813From Human herpesvirus 1.

Protein-protein interaction databases

IntActiH0YL14. 2 interactors.
STRINGi9606.ENSP00000453019.

Structurei

3D structure databases

ProteinModelPortaliH0YL14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00560000078707.
InParanoidiH0YL14.
OMAiGHRRLDF.
OrthoDBiEOG091G0VDQ.

Sequencei

Sequence statusi: Complete.

H0YL14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVMPIPRRV RSFHGPHTTC LHAACGPVRA SHLARTKYNN FDVYIKTRWL
60 70 80 90 100
YGFIRFLLYF SCSLFTAALW GALAALFCLQ YLGVRVLLRF QRKLSVLLLL
110 120 130
LGRRRVDFRL VNELLVYGIH VTMLLVGGLG WCFMVFVDM
Length:139
Mass (Da):16,083
Last modified:April 18, 2012 - v2
Checksum:i482DDEB661FD9A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138781 Genomic DNA. No translation available.
BC014304 mRNA. No translation available.
CCDSiCCDS59155.1.
RefSeqiNP_001243455.1. NM_001256526.1.
NP_690046.3. NM_152833.2.
UniGeneiHs.287411.

Genome annotation databases

EnsembliENST00000418388; ENSP00000453019; ENSG00000238227.
ENST00000557985; ENSP00000457272; ENSG00000238227.
ENST00000561457; ENSP00000452750; ENSG00000238227.
GeneIDi90120.
KEGGihsa:90120.
UCSCiuc004cgx.6. human.

Similar proteinsi

Entry informationi

Entry nameiTM250_HUMAN
AccessioniPrimary (citable) accession number: H0YL14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 18, 2012
Last modified: October 25, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM