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Protein
Submitted name:

Lactadherin

Gene

MFGE8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
LactadherinImported
Gene namesi
Name:MFGE8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:7036. MFGE8.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500354618524 – 268Sequence analysisAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 66PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiH0YKS8.
PaxDbiH0YKS8.
PeptideAtlasiH0YKS8.
PRIDEiH0YKS8.

Expressioni

Gene expression databases

BgeeiENSG00000140545.
ExpressionAtlasiH0YKS8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0YKS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 67EGF-likeInterPro annotationAdd BLAST45
Domaini70 – 225F5/8 type CInterPro annotationAdd BLAST156

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFBC. Eukaryota.
ENOG41114BV. LUCA.
GeneTreeiENSGT00760000119073.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR027060. Lactadherin.
PANTHERiPTHR10127:SF683. PTHR10127:SF683. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0YKS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPRLLAAL CGALLCAPSL LVALDICSKN PCHNGGLCEE ISQEVRGDVF
60 70 80 90 100
PSYTCTCLKG YAGNHCETKC VEPLGLENGN IANSQIAASS VRVTFLGLQH
110 120 130 140 150
WVPELARLNR AGMVNAWTPS SNDDNPWIQV NLLRRMWVTG VVTQGASRLA
160 170 180 190 200
SHEYLKAFKV AYSLNGHEFD FIHDVNKKHK EFVGNWNKNA VHVNLFETPV
210 220 230 240 250
EAQYVRLYPT SCHTACTLRF ELLGCELNAA TRPGACISSA GTPPMHGWTS
260
RATSTPGLRG ATVTISGC
Length:268
Mass (Da):29,168
Last modified:February 22, 2012 - v1
Checksum:iFA019024AA4C62E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei268Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067805 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000558029; ENSP00000452926; ENSG00000140545.
UCSCiuc059myl.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiH0YKS8_HUMAN
AccessioniPrimary (citable) accession number: H0YKS8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 5, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported