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Protein

Diacylglycerol kinase

Gene

DGKA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DGKAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2849. DGKA.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065357.

PTM / Processingi

Proteomic databases

MaxQBiH0YJH4.
PeptideAtlasiH0YJH4.
PRIDEiH0YJH4.

Expressioni

Gene expression databases

BgeeiENSG00000065357.
ExpressionAtlasiH0YJH4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0YJH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116DAGKcInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119050.

Family and domain databases

Gene3Di3.40.50.10330. 2 hits.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
PfamiView protein in Pfam
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
SMARTiView protein in SMART
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiView protein in PROSITE
PS50146. DAGK. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0YJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LRIDPVPNTH PLLVFVNPKS GGKQGQRLRL FKDVPDSRIL VCGGDGTVGW
60 70 80 90 100
ILETIDKANL PVLPPVAVLP LGTGNDLARC LRWGGGYEGQ NLAKILKDLE
110 120 130 140 150
MSKVVHMDRW SVEVIPQQTE EKSDPVPFQI INNYFSIGVD ASIAHRFHIM
160 170 180 190 200
REKYPEKFNS RMKNKLWYFE FATSESIFST CKKLEESLTV EICGKPLDLS

NL
Length:202
Mass (Da):22,765
Last modified:February 22, 2012 - v1
Checksum:iCF31E009049E028E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei202Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025162 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000552903; ENSP00000451518; ENSG00000065357.
UCSCiuc058pee.1. human.

Similar proteinsi

Entry informationi

Entry nameiH0YJH4_HUMAN
AccessioniPrimary (citable) accession number: H0YJH4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 10, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported