ID   H0YHK3_HUMAN            Unreviewed;      1104 AA.
AC   H0YHK3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=PTPRF interacting protein alpha 2 {ECO:0000313|Ensembl:ENSP00000447273.2};
GN   Name=PPFIA2 {ECO:0000313|Ensembl:ENSP00000447273.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000447273.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000447273.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000447273.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC       {ECO:0000256|ARBA:ARBA00007026}.
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DR   EMBL; AC011316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001269465.1; NM_001282536.1.
DR   AlphaFoldDB; H0YHK3; -.
DR   SMR; H0YHK3; -.
DR   MassIVE; H0YHK3; -.
DR   PeptideAtlas; H0YHK3; -.
DR   ProteomicsDB; 38729; -.
DR   Antibodypedia; 29823; 93 antibodies from 19 providers.
DR   DNASU; 8499; -.
DR   Ensembl; ENST00000550359.6; ENSP00000447273.2; ENSG00000139220.17.
DR   GeneID; 8499; -.
DR   UCSC; uc058rjo.1; human.
DR   CTD; 8499; -.
DR   HGNC; HGNC:9246; PPFIA2.
DR   VEuPathDB; HostDB:ENSG00000139220; -.
DR   GeneTree; ENSGT01050000244900; -.
DR   OMA; DHEWIGN; -.
DR   OrthoDB; 2906732at2759; -.
DR   BioGRID-ORCS; 8499; 16 hits in 1149 CRISPR screens.
DR   ChiTaRS; PPFIA2; human.
DR   GenomeRNAi; 8499; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139220; Expressed in cortical plate and 137 other cell types or tissues.
DR   ExpressionAtlas; H0YHK3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR   CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR   CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR   InterPro; IPR029515; Liprin.
DR   InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR   InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR   InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR   PANTHER; PTHR12587:SF6; LIPRIN-ALPHA-2; 1.
DR   Pfam; PF00536; SAM_1; 2.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 3.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR   PROSITE; PS50105; SAM_DOMAIN; 3.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|EPD:H0YHK3,
KW   ECO:0007829|MaxQB:H0YHK3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          745..811
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          874..931
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          955..1024
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          77..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          42..76
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          352..382
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          497..538
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        81..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..574
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1104 AA;  125906 MW;  BA107C7C0ECBFB3B CRC64;
     MTVVKRQAQS PSGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVSLERVS ALEEELAAAN
     QEIVALREQN VHIQRKMASS EGSTESEHLE GMEPGQKVHE KRLSNGSIDS TDETSQIVEL
     QELLEKQNYE MAQMKERLAA LSSRVGEVEQ EAETARKDLI KTEEMNTKYQ RDIREAMAQK
     EDMEERITTL EKRYLSAQRE STSIHDMNDK LENELANKEA ILRQMEEKNR QLQERLELAE
     QKLQQTMRKA ETLPEVEAEL AQRIAALTKA EERHGNIEER MRHLEGQLEE KNQELQRARQ
     REKMNEEHNK RLSDTVDRLL TESNERLQLH LKERMAALEE KNVLIQESET FRKNLEESLH
     DKERLAEEIE KLRSELDQLK MRTGSLIEPT IPRTHLDTSA ELRYSVGSLV DSQSDYRTTK
     VIRRPRRGRM GVRRDEPKVK SLGDHEWNRT QQIGVLSSHP FESDTEMSDI DDDDRETIFS
     SMDLLSPSGH SDAQTLAMML QEQLDAINKE IRLIQEEKES TELRAEEIEN RVASVSLEGL
     NLARVHPGTS ITASVTASSL ASSSPPSGHS TPKLTPRSPA REMDRMGVMT LPSDLRKHRR
     KIAVVEEDGR EDKATIKCET SPPPTPRALR MTHTLPSSYH NDARSSLSVS LEPESLGLGS
     ANSSQDSLHK APKKKGIKSS IGRLFGKKEK ARLGQLRGFM ETEAAAQESL GLGKLGTQAE
     KDRRLKKKHE LLEEARRKGL PFAQWDGPTV VAWLELWLGM PAWYVAACRA NVKSGAIMSA
     LSDTEIQREI GISNPLHRLK LRLAIQEMVS LTSPSAPPTS RTPSGNVWVT HEEMENLAAP
     AKTKESEEGS WAQCPVFLQT LAYGDMNHEW IGNEWLPSLG LPQYRSYFME CLVDARMLDH
     LTKKDLRVHL KMVDSFHRTS LQYGIMCLKR LNYDRKELER RREASQHEIK DVLVWSNDRV
     IRWIQAIGLR EYANNILESG VHGSLIALDE NFDYSSLALL LQIPTQNTQA RQILEREYNN
     LLALGTERRL DESDDKNFRR GSTWRRQFPP REVHGISMMP GSSETLPAGF RLTTTSGQSR
     KMTTDVASSR LQRLDNSTVR TYSC
//