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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 8

Gene

LRP8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 8Imported
Gene namesi
Name:LRP8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157193.14
HGNCiHGNC:6700 LRP8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157193

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 79PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiH0YEV6
PRIDEiH0YEV6

Expressioni

Gene expression databases

BgeeiENSG00000157193
ExpressionAtlasiH0YEV6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YEV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 64EGF-likeInterPro annotationAdd BLAST40
Domaini65 – 104EGF-likeInterPro annotationAdd BLAST40
Repeati151 – 197LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati198 – 240LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118968

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00058 Ldl_recept_b, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00135 LY, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS51120 LDLRB, 2 hits

Sequencei

Sequence statusi: Fragment.

H0YEV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XDGSDEAGCL QVPPTFLGNR RRPRGLNECL HNNGGCSHIC TDLKIGFECT
60 70 80 90 100
CPAGFQLLDQ KTCGDIDECK DPDACSQICV NYKGYFKCEC YPGYEMDLLT
110 120 130 140 150
KNCKAAAGKS PSLIFTNRHE VRRIDLVKRN YSRLIPMLKN VVALDVEVAT
160 170 180 190 200
NRIYWCDLSY RKIYSAYMDK ASDPKEQEVL IDEQLHSPEG LAVDWVHKHI
210 220 230 240
YWTDSGNKTI SVATVDGGRR RTLFSRNLSE PRAIAVDPLR
Length:240
Mass (Da):27,084
Last modified:October 5, 2016 - v8
Checksum:i0A29C11C8600CED6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei240Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355483 Genomic DNA No translation available.
AL606760 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000475501; ENSP00000436651; ENSG00000157193
UCSCiuc057gro.1 human

Similar proteinsi

Entry informationi

Entry nameiH0YEV6_HUMAN
AccessioniPrimary (citable) accession number: H0YEV6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 54 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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