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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 8

Gene

LRP8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 8Imported
Gene namesi
Name:LRP8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6700. LRP8.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157193.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiH0YEV6.
PRIDEiH0YEV6.

Expressioni

Gene expression databases

ExpressionAtlasiH0YEV6. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 64EGF-likeInterPro annotationAdd BLAST40
Domaini65 – 104EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118968.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51120. LDLRB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0YEV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XDGSDEAGCL QVPPTFLGNR RRPRGLNECL HNNGGCSHIC TDLKIGFECT
60 70 80 90 100
CPAGFQLLDQ KTCGDIDECK DPDACSQICV NYKGYFKCEC YPGYEMDLLT
110 120 130 140 150
KNCKAAAGKS PSLIFTNRHE VRRIDLVKRN YSRLIPMLKN VVALDVEVAT
160 170 180 190 200
NRIYWCDLSY RKIYSAYMDK ASDPKEQEVL IDEQLHSPEG LAVDWVHKHI
210 220 230 240
YWTDSGNKTI SVATVDGGRR RTLFSRNLSE PRAIAVDPLR
Length:240
Mass (Da):27,084
Last modified:October 5, 2016 - v8
Checksum:i0A29C11C8600CED6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei240Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355483 Genomic DNA. No translation available.
AL606760 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000475501; ENSP00000436651; ENSG00000157193.
UCSCiuc057gro.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355483 Genomic DNA. No translation available.
AL606760 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YEV6.
PRIDEiH0YEV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000475501; ENSP00000436651; ENSG00000157193.
UCSCiuc057gro.1. human.

Organism-specific databases

HGNCiHGNC:6700. LRP8.
OpenTargetsiENSG00000157193.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118968.

Miscellaneous databases

ChiTaRSiLRP8. human.

Gene expression databases

ExpressionAtlasiH0YEV6. baseline and differential.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51120. LDLRB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0YEV6_HUMAN
AccessioniPrimary (citable) accession number: H0YEV6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 5, 2016
Last modified: November 2, 2016
This is version 43 of the entry and version 8 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.