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Protein
Submitted name:

7-dehydrocholesterol reductase

Gene

DHCR7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
7-dehydrocholesterol reductaseImported
Gene namesi
Name:DHCR7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2860. DHCR7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Transmembranei58 – 7518HelicalSequence analysisAdd
BLAST
Transmembranei91 – 10717HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiH0YEJ5.
PeptideAtlasiH0YEJ5.

Expressioni

Gene expression databases

BgeeiENSG00000172893.
ExpressionAtlasiH0YEJ5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347717.

Structurei

3D structure databases

ProteinModelPortaliH0YEJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
GeneTreeiENSGT00390000000417.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0YEJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TGNFFYNYMM GIEFNPRIGK WFDFKLFFNG RPGIVAWTLI NLSFAAKQRE
60 70 80 90 100
LHSHVTNAMV LVNVLQAIYV IDFFWNETWY LKTIDICHDH FGWYLGWGDC
110 120 130 140 150
VWLPYLYTLQ KRTRRQGVCQ RQSWGLTPGR WAPEPTLLSS PWAKHRLTPS
160 170 180 190 200
PSPPRVCTWC TTPCSCPPRT PWASCCWAWW ATTSSGWPTT RRTCSAARMG
210 220 230 240
AASSGAGSPR SSSAPTHPPM GRGTTASCWC RASGAWPATS TTSAT
Length:245
Mass (Da):27,644
Last modified:February 22, 2012 - v1
Checksum:i9C99C1D658E396C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002387 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000525137; ENSP00000435956; ENSG00000172893.
UCSCiuc058euk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002387 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH0YEJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347717.

Proteomic databases

PaxDbiH0YEJ5.
PeptideAtlasiH0YEJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525137; ENSP00000435956; ENSG00000172893.
UCSCiuc058euk.1. human.

Organism-specific databases

HGNCiHGNC:2860. DHCR7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
GeneTreeiENSGT00390000000417.

Miscellaneous databases

ChiTaRSiDHCR7. human.

Gene expression databases

BgeeiENSG00000172893.
ExpressionAtlasiH0YEJ5. baseline and differential.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0YEJ5_HUMAN
AccessioniPrimary (citable) accession number: H0YEJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 7, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.