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Protein
Submitted name:

Caspase-1

Gene

CASP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-1Imported
Gene namesi
Name:CASP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1499. CASP1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137752.

PTM / Processingi

Proteomic databases

MaxQBiH0YEC7.
PaxDbiH0YEC7.
PeptideAtlasiH0YEC7.
PRIDEiH0YEC7.

Expressioni

Gene expression databases

BgeeiENSG00000137752.
ExpressionAtlasiH0YEC7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410076.

Structurei

3D structure databases

ProteinModelPortaliH0YEC7.
SMRiH0YEC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 138CASPASE_P20InterPro annotationAdd BLAST129
Domaini166 – 221CASPASE_P10InterPro annotationAdd BLAST56

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0YEC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IYPIMDKSSR TRLALIICNE EFDSIPRRTG AEVDITGMTM LLQNLGYSVD
60 70 80 90 100
VKKNLTASDM TTELEAFAHR PEHKTSDSTF LVFMSHGIRE GICGKKHSEQ
110 120 130 140 150
VPDILQLNAI FNMLNTKNCP SLKDKPKVII IQACRGDSPG VVWFKDSVGV
160 170 180 190 200
SGNLSLPTTE EFEDDAIKKA HIEKDFIAFC SSTPDNVSWR HPTMGSVFIG
210 220 230
RLIEHMQEYA CSCDVEEIFR KEVKRSFCKG FWNYVC
Length:236
Mass (Da):26,667
Last modified:February 22, 2012 - v1
Checksum:iD768A60A0DCDFA59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001153 Genomic DNA. No translation available.
KF455483 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000532439; ENSP00000435536; ENSG00000137752.
UCSCiuc058gya.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001153 Genomic DNA. No translation available.
KF455483 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH0YEC7.
SMRiH0YEC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000410076.

Proteomic databases

MaxQBiH0YEC7.
PaxDbiH0YEC7.
PeptideAtlasiH0YEC7.
PRIDEiH0YEC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532439; ENSP00000435536; ENSG00000137752.
UCSCiuc058gya.1. human.

Organism-specific databases

HGNCiHGNC:1499. CASP1.
OpenTargetsiENSG00000137752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.

Miscellaneous databases

ChiTaRSiCASP1. human.

Gene expression databases

BgeeiENSG00000137752.
ExpressionAtlasiH0YEC7. baseline and differential.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0YEC7_HUMAN
AccessioniPrimary (citable) accession number: H0YEC7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 30, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.