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Protein
Submitted name:

Breast cancer type 2 susceptibility protein

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer type 2 susceptibility proteinImported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:1101. BRCA2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139618.

PTM / Processingi

Proteomic databases

PeptideAtlasiH0YE37.

Expressioni

Gene expression databases

ExpressionAtlasiH0YE37. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0YE37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 156BRCA-2_OB3InterPro annotationAdd BLAST119

Phylogenomic databases

GeneTreeiENSGT00390000003602.

Family and domain databases

InterProiView protein in InterPro
IPR015525. BRCA2.
IPR015188. BRCA2_OB_3.
IPR012340. NA-bd_OB-fold.
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiView protein in Pfam
PF09104. BRCA-2_OB3. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0YE37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XSKSKSERAN IQLAATKKTQ YQQLPVSDEI LFQIYQPREP LHFSKFLDPD
60 70 80 90 100
FQPSCSEVDL IGFVVSVVKK TGLAPFVYLS DECYNLLAIK FWIDLNEDII
110 120 130 140 150
KPHMLIAASN LQWRPESKSG LLTLFAGDFS VFSASPKEGH FQETFNKMKN
160 170 180
TVERQSLALS PPGWSTIAQS RITAVSASWA QAILVP
Length:186
Mass (Da):20,864
Last modified:February 22, 2012 - v1
Checksum:iE6EEA549E0637A0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137247 Genomic DNA. No translation available.
AL445212 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000470094; ENSP00000434898; ENSG00000139618.
UCSCiuc058wfx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137247 Genomic DNA. No translation available.
AL445212 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH0YE37.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YE37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470094; ENSP00000434898; ENSG00000139618.
UCSCiuc058wfx.1. human.

Organism-specific databases

HGNCiHGNC:1101. BRCA2.
OpenTargetsiENSG00000139618.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003602.

Gene expression databases

ExpressionAtlasiH0YE37. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR015525. BRCA2.
IPR015188. BRCA2_OB_3.
IPR012340. NA-bd_OB-fold.
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiView protein in Pfam
PF09104. BRCA-2_OB3. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH0YE37_HUMAN
AccessioniPrimary (citable) accession number: H0YE37
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 15, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.