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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

DLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:DLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000150768.15.
HGNCiHGNC:2896. DLAT.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150768.

PTM / Processingi

Proteomic databases

MaxQBiH0YDD4.
PeptideAtlasiH0YDD4.
PRIDEiH0YDD4.

Expressioni

Gene expression databases

BgeeiENSG00000150768.
ExpressionAtlasiH0YDD4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0YDD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 126Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini188 – 225Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557. Eukaryota.
COG0508. LUCA.
GeneTreeiENSGT00890000139393.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom_sf.
IPR036625. E3-bd_dom_sf.
IPR006257. LAT1.
IPR004167. PSBD.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
PS51826. PSBD. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0YDD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PARRNSVTTG YGGVRALCGW TPSSGATPRN RLLLQLLGSP GRRYYSLPPH
60 70 80 90 100
QKVPLPSLSP TMQAGTIARW EKKEGDKINE GDLLAEIETD KATIGFEVQE
110 120 130 140 150
EGYLAKILVP EGTRDVPLGT PLCIIVEKEA DISAFADYRP TEVTDLKPQV
160 170 180 190 200
PPPTPPPVAA VPPTPQPLAP TPSAPCPATP AGPKGRVFVS PLAKKLAVEK
210 220 230 240 250
GIDLTQVKGT GPDGRITKKD IDSFVPSKVA PAPAAVVPPT GPGMAPVPTG
260 270 280 290 300
VFTDIPISNI RRVIAQRLMQ SKQTIPHYYL SIDVNMGEVL LVRKELNKIL
310 320 330 340 350
EGRSKISVND FIIKASALAC LKVPEANSSW MDTVIRQNHV VDVSVAVSTP
360 370 380 390 400
AGLITPIVFN AHIKGVETIA NDVVSLATKA REGKLQPHEF QGGTFTISNL
410 420 430 440 450
GMFGIKNFSA IINPPQACIL AIGASEDKLV PADNEKGFDV ASMMSVTLSC
460 470
DHRVVDGAVG AQWLAEFRKY LEKPITMLL
Length:479
Mass (Da):51,201
Last modified:February 22, 2012 - v1
Checksum:i53A2B6EA6642A364
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000907 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000531306; ENSP00000433432; ENSG00000150768.
UCSCiuc058hhb.1. human.

Similar proteinsi

Entry informationi

Entry nameiH0YDD4_HUMAN
AccessioniPrimary (citable) accession number: H0YDD4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported