ANK2

Functionⁱ

GO - Biological processⁱ

signal transduction Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ankyrin-2Imported
Gene namesⁱ	Name:ANK2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145362.17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:493. ANK2.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000145362.

OpenTargetsⁱ

ENSG00000145362.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	H0Y931.
PeptideAtlas More...PeptideAtlasⁱ	H0Y931.
PRIDEⁱ	H0Y931.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000145362.
ExpressionAtlasⁱ	H0Y931. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	H0Y931.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	12 – 119	ZU5InterPro annotationAdd BLAST		108
Domainⁱ	486 – 570	DeathInterPro annotationAdd BLAST		85

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129677.

GeneTreeⁱ

ENSGT00840000129677.

Family and domain databases

InterProⁱ	View protein in InterPro IPR030301. Ankyrin-B. IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR000906. ZU5_dom.
PANTHERⁱ	PTHR24123:SF34. PTHR24123:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531. Death. 1 hit. PF00791. ZU5. 2 hits.
SMARTⁱ	View protein in SMART SM00005. DEATH. 1 hit. SM00218. ZU5. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50017. DEATH_DOMAIN. 1 hit. PS51145. ZU5. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

H0Y931-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
XNVALSSSPI HSGFLVSFMV DARGGAMRGC RHNGLRIIIP PRKCTAPTRV 
        60         70         80         90        100
TCRLVKRHRL ATMPPMVEGE GLASRLIEVG PSGAQFLGPV IVEIPHFAAL 
       110        120        130        140        150
RGKERELVVL RSENGDSWKE HFCDYTEDEL NEILNGMDEV LDSPEDLEKK 
       160        170        180        190        200
RICRIITRDF PQYFAVVSRI KQDSNLIGPE GGVLSSTVVP QVQAVFPEGA 
       210        220        230        240        250
LTKRIRVGLQ AQPMHSELVK KILGNKATFS PIVTLEPRRR KFHKPITMTI 
       260        270        280        290        300
PVPKASSDVM LNGFGGDAPT LRLLCSITGG TTPAQWEDIT GTTPLTFVNE 
       310        320        330        340        350
CVSFTTNVSA RFWLIDCRQI QESVTFASQV YREIICVPYM AKFVVFAKSH 
       360        370        380        390        400
DPIEARLRCF CMTDDKVDKT LEQQENFAEV ARSRDVEVLE GKPIYVDCFG 
       410        420        430        440        450
NLVPLTKSGQ HHIFSFFAFK ENRLPLFVKV RDTTQEPCGR LSFMKEPKST 
       460        470        480        490        500
RGLVHQAICN LNITLPIYTK IDMTSEKNPQ DEQERIEERL AYIADHLGFS 
       510        520        530        540        550
WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER DGKHATDTNL 
       560        570        580        590        600
VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL DHSEGFSVLQ 
       610        620        630        640        650
EELCTAQHKQ KEEQAVSKES ETCDHPPIVS EEDISVGYST FQDGVPKTEG 
       660        670        680        690        700
DSSATALFPQ THKEQVQQDF SGKMQDLPEE SSLEYQQEYF VTTPGTETSE 
       710        720        730        740        750
TQKAMIVPSS PSKTPEEVST PAEEEKLYLQ TPTSSERGGS PIIQEPEEPS 
       760        770        780        790        800
EHREESSPRK TSLVIVESAD NQPETCERLD EDAAFEKELT EELGELEASS 
       810        820        830        840        850
DEEAMVTTRV VRRRVIIQGD DMPEIPPETV TEEEYIDEHG HTVVKKVTRK 
       860        870        880        890        900
IIRRYVSSEG TEKEEIMVQG MPQEPVNIEE GDGYSKVIKR VVLKSDTEQS 
       910        920        930        940        950
EVTLCEPSIL SSTSQFQAEP VEGRRVSKVV KTTVVLGERM EKHLGDSSLA 
       960 
TDLPSAKDDF EEDNNE

Length:966

Mass (Da):108,728

Last modified:February 22, 2012 - v1

Checksum:ⁱ661F6E2132935F46

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004057 Genomic DNA. No translation available. AC017007 Genomic DNA. No translation available. AC093617 Genomic DNA. No translation available. AC093879 Genomic DNA. No translation available. AC093900 Genomic DNA. No translation available. AC108042 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000514960; ENSP00000422853; ENSG00000145362.
UCSC genome browser More...UCSCⁱ	uc062zdl.1. human.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
H0Y931	Q7Z344	Homo sapiens (Human)	966	UniRef90_H0Y931	Cluster: Ankyrin-2 (Fragment)	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
H0Y931	E9PCH6 F7H0Q9 B7Z2H4 F7H4E6 Q7Z344 M4ASZ7 A0A1A8QF36 UPI00054F3C6E H0V163 H2T7S1 +3	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Macaca mulatta (Rhesus macaque) Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Nothobranchius rachovii (bluefin notho) Notothenia coriiceps (black rockcod) Cavia porcellus (Guinea pig) Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Cervus elaphus hippelaphus (European red deer) Callorhinchus milii (Ghost shark) And more	1,048	UniRef50_E9PCH6	Cluster: Ankyrin-2	14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004057 Genomic DNA. No translation available. AC017007 Genomic DNA. No translation available. AC093617 Genomic DNA. No translation available. AC093879 Genomic DNA. No translation available. AC093900 Genomic DNA. No translation available. AC108042 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	H0Y931.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	H0Y931.
PeptideAtlas More...PeptideAtlasⁱ	H0Y931.
PRIDEⁱ	H0Y931.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000514960; ENSP00000422853; ENSG00000145362.
UCSC genome browser More...UCSCⁱ	uc062zdl.1. human.

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145362.17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:493. ANK2.
Open Targets More...OpenTargetsⁱ	ENSG00000145362.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129677.

GeneTreeⁱ

ENSGT00840000129677.

Miscellaneous databases

ChiTaRSⁱ	ANK2. human.

ChiTaRSⁱ

ANK2. human.

Gene expression databases

Bgeeⁱ	ENSG00000145362.
ExpressionAtlasⁱ	H0Y931. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR030301. Ankyrin-B. IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR000906. ZU5_dom.
PANTHERⁱ	PTHR24123:SF34. PTHR24123:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531. Death. 1 hit. PF00791. ZU5. 2 hits.
SMARTⁱ	View protein in SMART SM00005. DEATH. 1 hit. SM00218. ZU5. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50017. DEATH_DOMAIN. 1 hit. PS51145. ZU5. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0Y931_HUMAN
Accessionⁱ	H0Y931Primary (citable) accession number: H0Y931
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	February 22, 2012
	Last modified:	September 27, 2017
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H0Y931 (H0Y931_HUMAN)

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Ankyrin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ