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UniProtKB - H0Y8A4 (H0Y8A4_HUMAN)

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Protein
Submitted name:

Tyrosine-protein kinase RYK

Gene

RYK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase RYKImported
Gene namesi
Name:RYKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10481. RYK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163785.

PTM / Processingi

Proteomic databases

PaxDbiH0Y8A4.
PeptideAtlasiH0Y8A4.
PRIDEiH0Y8A4.

Expressioni

Gene expression databases

ExpressionAtlasiH0Y8A4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296084.

Structurei

3D structure databases

ProteinModelPortaliH0Y8A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 132WIFInterPro annotationAdd BLAST129
Domaini271 – 544Protein kinaseInterPro annotationAdd BLAST274

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
GeneTreeiENSGT00810000125384.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR003306. WIF.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF02019. WIF. 1 hit.
PRINTSiPR00109. TYRKINASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948. WIF. 1 hit.
SMARTiView protein in SMART
SM00469. WIF. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50814. WIF. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0Y8A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SVSLYLSEDE VRRLIGLDAE LYYVRNDLIS HYALSFSLLV PSETNFLHFT 
        60         70         80         90        100
WHAKSKVEYK LGFQVDNVLA MDMPQVNISV QGEVPRTLSV FRVELSCTGK 
       110        120        130        140        150
VDSEVMILMQ LNLTVNSSKN FTVLNFKRRK MCYKKLEEVK TSALDKNTSR 
       160        170        180        190        200
TIYDPVHAAP TTSTRVFYIS VGVCCAVIFL VAIILAVLHL HSMKRIELDD 
       210        220        230        240        250
SISASSSSQG LSQPSTQTTQ YLRADTPNNA TPITSSLGYP TLRIEKNDLR 
       260        270        280        290        300
SVTLLEAKGK VKDIAISRER ITLKDVLQEG TFGRIFHGIL IDEKDPNKEK 
       310        320        330        340        350
QAFVKTVKDQ ASEIQVTMML TESCKLRGLH HRNLLPITHV CIEEGEKPMV 
       360        370        380        390        400
ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI ACGMSYLARR 
       410        420        430        440        450
EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 
       460        470        480        490        500
ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY 
       510        520        530        540 
RIAQPINCPD ELFAVMACCW ALDPEERPKF QQLVQCLTEF HAALGAYV
Length:548
Mass (Da):61,975
Last modified:November 26, 2014 - v2
Checksum:iC1940EA15623395B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096967 Genomic DNA. No translation available.
AC107310 Genomic DNA. No translation available.
AC108742 Genomic DNA. No translation available.
AMYH02007719 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000460933; ENSP00000419122; ENSG00000163785.
UCSCiuc062oar.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096967 Genomic DNA. No translation available.
AC107310 Genomic DNA. No translation available.
AC108742 Genomic DNA. No translation available.
AMYH02007719 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH0Y8A4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296084.

Proteomic databases

PaxDbiH0Y8A4.
PeptideAtlasiH0Y8A4.
PRIDEiH0Y8A4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000460933; ENSP00000419122; ENSG00000163785.
UCSCiuc062oar.1. human.

Organism-specific databases

HGNCiHGNC:10481. RYK.
OpenTargetsiENSG00000163785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
GeneTreeiENSGT00810000125384.

Miscellaneous databases

ChiTaRSiRYK. human.

Gene expression databases

ExpressionAtlasiH0Y8A4. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR003306. WIF.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF02019. WIF. 1 hit.
PRINTSiPR00109. TYRKINASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948. WIF. 1 hit.
SMARTiView protein in SMART
SM00469. WIF. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50814. WIF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y8A4_HUMAN
AccessioniPrimary (citable) accession number: H0Y8A4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 26, 2014
Last modified: March 15, 2017
This is version 35 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.