UniProtKB - H0Y8A4 (H0Y8A4_HUMAN)
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Protein
Submitted name:
Tyrosine-protein kinase RYK
Gene
RYK
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- protein kinase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Tyrosine-protein kinase RYKImported |
Gene namesi | Name:RYKImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163785.12. |
HGNCi | HGNC:10481. RYK. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 166 – 188 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000163785. |
ExpressionAtlasi | H0Y8A4. baseline and differential. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 132 | WIFInterPro annotationAdd BLAST | 129 | |
Domaini | 271 – 544 | Protein kinaseInterPro annotationAdd BLAST | 274 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG1024. Eukaryota. ENOG410XSKI. LUCA. |
GeneTreei | ENSGT00810000125384. |
Family and domain databases
InterProi | View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR003306. WIF. |
Pfami | View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF02019. WIF. 1 hit. |
PRINTSi | PR00109. TYRKINASE. |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD013948. WIF. 1 hit. |
SMARTi | View protein in SMART SM00469. WIF. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50814. WIF. 1 hit. |
i Sequence
Sequence statusi: Fragment.
H0Y8A4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SVSLYLSEDE VRRLIGLDAE LYYVRNDLIS HYALSFSLLV PSETNFLHFT
60 70 80 90 100
WHAKSKVEYK LGFQVDNVLA MDMPQVNISV QGEVPRTLSV FRVELSCTGK
110 120 130 140 150
VDSEVMILMQ LNLTVNSSKN FTVLNFKRRK MCYKKLEEVK TSALDKNTSR
160 170 180 190 200
TIYDPVHAAP TTSTRVFYIS VGVCCAVIFL VAIILAVLHL HSMKRIELDD
210 220 230 240 250
SISASSSSQG LSQPSTQTTQ YLRADTPNNA TPITSSLGYP TLRIEKNDLR
260 270 280 290 300
SVTLLEAKGK VKDIAISRER ITLKDVLQEG TFGRIFHGIL IDEKDPNKEK
310 320 330 340 350
QAFVKTVKDQ ASEIQVTMML TESCKLRGLH HRNLLPITHV CIEEGEKPMV
360 370 380 390 400
ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI ACGMSYLARR
410 420 430 440 450
EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM
460 470 480 490 500
ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY
510 520 530 540
RIAQPINCPD ELFAVMACCW ALDPEERPKF QQLVQCLTEF HAALGAYV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096967 Genomic DNA. No translation available. AC107310 Genomic DNA. No translation available. AC108742 Genomic DNA. No translation available. AMYH02007719 Genomic DNA. No translation available. |
Genome annotation databases
Ensembli | ENST00000460933; ENSP00000419122; ENSG00000163785. |
UCSCi | uc062oar.1. human. |
Similar proteinsi
Entry informationi
Entry namei | H0Y8A4_HUMAN | |
Accessioni | H0Y8A4Primary (citable) accession number: H0Y8A4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | November 26, 2014 | |
Last modified: | March 28, 2018 | |
This is version 42 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |