RYK

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tyrosine-protein kinase RYKImported
Gene namesⁱ	Name:RYKImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163785.12.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10481. RYK.

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	166 – 188	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000163785.

OpenTargetsⁱ

ENSG00000163785.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	H0Y8A4.
PeptideAtlas More...PeptideAtlasⁱ	H0Y8A4.
PRIDEⁱ	H0Y8A4.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163785.
ExpressionAtlasⁱ	H0Y8A4. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	H0Y8A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 132	WIFInterPro annotationAdd BLAST		129
Domainⁱ	271 – 544	Protein kinaseInterPro annotationAdd BLAST		274

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1024. Eukaryota. ENOG410XSKI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125384.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR003306. WIF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF02019. WIF. 1 hit.
PRINTSⁱ	PR00109. TYRKINASE.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD013948. WIF. 1 hit.
SMARTⁱ	View protein in SMART SM00469. WIF. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50814. WIF. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

H0Y8A4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
SVSLYLSEDE VRRLIGLDAE LYYVRNDLIS HYALSFSLLV PSETNFLHFT 
        60         70         80         90        100
WHAKSKVEYK LGFQVDNVLA MDMPQVNISV QGEVPRTLSV FRVELSCTGK 
       110        120        130        140        150
VDSEVMILMQ LNLTVNSSKN FTVLNFKRRK MCYKKLEEVK TSALDKNTSR 
       160        170        180        190        200
TIYDPVHAAP TTSTRVFYIS VGVCCAVIFL VAIILAVLHL HSMKRIELDD 
       210        220        230        240        250
SISASSSSQG LSQPSTQTTQ YLRADTPNNA TPITSSLGYP TLRIEKNDLR 
       260        270        280        290        300
SVTLLEAKGK VKDIAISRER ITLKDVLQEG TFGRIFHGIL IDEKDPNKEK 
       310        320        330        340        350
QAFVKTVKDQ ASEIQVTMML TESCKLRGLH HRNLLPITHV CIEEGEKPMV 
       360        370        380        390        400
ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI ACGMSYLARR 
       410        420        430        440        450
EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 
       460        470        480        490        500
ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY 
       510        520        530        540 
RIAQPINCPD ELFAVMACCW ALDPEERPKF QQLVQCLTEF HAALGAYV

Length:548

Mass (Da):61,975

Last modified:November 26, 2014 - v2

Checksum:ⁱC1940EA15623395B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC096967 Genomic DNA. No translation available. AC107310 Genomic DNA. No translation available. AC108742 Genomic DNA. No translation available. AMYH02007719 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC096967 Genomic DNA. No translation available.
AC107310 Genomic DNA. No translation available.
AC108742 Genomic DNA. No translation available.
AMYH02007719 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000460933; ENSP00000419122; ENSG00000163785.
UCSC genome browser More...UCSCⁱ	uc062oar.1. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
H0Y8A4	P34925-2 Q8WTZ8	Homo sapiens (Human)	610	UniRef100_P34925-2	Cluster: Isoform 2 of Tyrosine-protein kinase RYK	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
H0Y8A4	Q01887 Q71UK0 H3BKH8 A0A2K6QF79 A0A2K5QP83 UPI0006264742 A0A2K5P4X6 A0A2J8S2D4 A0A2J8S2F2 A0A2J8QIX2 +65	Mus musculus (Mouse) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Macaca nemestrina (Pig-tailed macaque) Piliocolobus tephrosceles (Ugandan red Colobus) Homo sapiens (Human) And more	594	UniRef90_Q01887	Cluster: Tyrosine-protein kinase RYK	76

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
H0Y8A4	Q01887 Q71UK0 H3BKH8 A0A2K6QF79 A0A2K5P4X6 A0A2K5QP83 UPI0006264742 A0A2J8S2D4 A0A2J8S2F2 A0A2J8QIX2 +300	Mus musculus (Mouse) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Macaca nemestrina (Pig-tailed macaque) Piliocolobus tephrosceles (Ugandan red Colobus) Homo sapiens (Human) And more	594	UniRef50_Q01887	Cluster: Tyrosine-protein kinase RYK	311

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC096967 Genomic DNA. No translation available. AC107310 Genomic DNA. No translation available. AC108742 Genomic DNA. No translation available. AMYH02007719 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC096967 Genomic DNA. No translation available.
AC107310 Genomic DNA. No translation available.
AC108742 Genomic DNA. No translation available.
AMYH02007719 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	H0Y8A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	H0Y8A4.
PeptideAtlas More...PeptideAtlasⁱ	H0Y8A4.
PRIDEⁱ	H0Y8A4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000460933; ENSP00000419122; ENSG00000163785.
UCSC genome browser More...UCSCⁱ	uc062oar.1. human.

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163785.12.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10481. RYK.
Open Targets More...OpenTargetsⁱ	ENSG00000163785.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1024. Eukaryota. ENOG410XSKI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125384.

Miscellaneous databases

ChiTaRSⁱ	RYK. human.

ChiTaRSⁱ

RYK. human.

Gene expression databases

Bgeeⁱ	ENSG00000163785.
ExpressionAtlasⁱ	H0Y8A4. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR003306. WIF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF02019. WIF. 1 hit.
PRINTSⁱ	PR00109. TYRKINASE.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD013948. WIF. 1 hit.
SMARTⁱ	View protein in SMART SM00469. WIF. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50814. WIF. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0Y8A4_HUMAN
Accessionⁱ	H0Y8A4Primary (citable) accession number: H0Y8A4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	November 26, 2014
	Last modified:	March 28, 2018
	This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H0Y8A4 (H0Y8A4_HUMAN)

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Tyrosine-protein kinase RYK

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ