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Protein
Submitted name:

Transient receptor potential cation channel subfamily M member 8

Gene

TRPM8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel subfamily M member 8Imported
Gene namesi
Name:TRPM8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17961. TRPM8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei90 – 108HelicalSequence analysisAdd BLAST19
Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei157 – 176HelicalSequence analysisAdd BLAST20
Transmembranei216 – 245HelicalSequence analysisAdd BLAST30
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144481.

PTM / Processingi

Proteomic databases

PaxDbiH0Y7P0.

Expressioni

Gene expression databases

BgeeiENSG00000144481.
ExpressionAtlasiH0Y7P0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323926.

Structurei

3D structure databases

ProteinModelPortaliH0Y7P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 249Ion_transInterPro annotationAdd BLAST204

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410INBX. Eukaryota.
ENOG4110YBY. LUCA.
GeneTreeiENSGT00760000119127.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view]
PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0Y7P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TECYSSDEDL AEQLLVYSCE AWGGSNCLEL AVEATDQHFI AQPGVQWYVN
60 70 80 90 100
GVNYFTDLWN VMDTLGLFYF IAGIVFRLHS SNKSSLYSGR VIFCLDYIIF
110 120 130 140 150
TLRLIHIFTV SRNLGPKIIM LQRMLIDVFF FLFLFAVWMV AFGVARQGIL
160 170 180 190 200
RQNEQRWRWI FRSVIYEPYL AMFGQVPSDV DGTTYDFAHC TFTGNESKPL
210 220 230 240 250
CVELDEHNLP RFPEWITIPL VCIYMLSTNI LLVNLLVAMF GYTVGTVQEN
260 270 280 290 300
NDQVWKFQRY FLVQEYCSRL NIPFPFIVFA YFYMVVKKCF KCCCKEKNME
310 320 330 340 350
SSVCCFKNED NETLAWEGVM KENYLVKINT KANDTSEEMR HRFRQLDTKI
360 370
ILRNADEQFC YRLLNERFSD PWVHGG
Length:376
Mass (Da):44,149
Last modified:February 22, 2012 - v1
Checksum:i080B241081061800
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005538 Genomic DNA. No translation available.
KF510796 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000456930; ENSP00000414198; ENSG00000144481.
UCSCiuc061two.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005538 Genomic DNA. No translation available.
KF510796 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH0Y7P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323926.

Proteomic databases

PaxDbiH0Y7P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456930; ENSP00000414198; ENSG00000144481.
UCSCiuc061two.1. human.

Organism-specific databases

HGNCiHGNC:17961. TRPM8.
OpenTargetsiENSG00000144481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INBX. Eukaryota.
ENOG4110YBY. LUCA.
GeneTreeiENSGT00760000119127.

Gene expression databases

BgeeiENSG00000144481.
ExpressionAtlasiH0Y7P0. baseline and differential.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view]
PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y7P0_HUMAN
AccessioniPrimary (citable) accession number: H0Y7P0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 2, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.