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Protein

Phosphatase and actin regulator

Gene

PHACTR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatase and actin regulatorUniRule annotation
Gene namesi
Name:PHACTR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20990. PHACTR1.

PTM / Processingi

Proteomic databases

PaxDbiH0Y518.

Expressioni

Gene expression databases

ExpressionAtlasiH0Y518. baseline and differential.

Interactioni

Subunit structurei

Binds PPP1CA and actin.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000329880.

Structurei

3D structure databases

ProteinModelPortaliH0Y518.
SMRiH0Y518. Positions 41-70, 327-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatase and actin regulator family.UniRule annotation
Contains 4 RPEL repeats.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiENOG410IMQP. Eukaryota.
ENOG411029R. LUCA.
GeneTreeiENSGT00390000004420.

Family and domain databases

InterProiIPR029987. Phactr1.
IPR004018. RPEL_repeat.
[Graphical view]
PANTHERiPTHR12751:SF6. PTHR12751:SF6. 1 hit.
PfamiPF02755. RPEL. 4 hits.
[Graphical view]
SMARTiSM00707. RPEL. 4 hits.
[Graphical view]
PROSITEiPS51073. RPEL. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H0Y518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSDSLVPGT HTPPIRRRSK FANLGRIFKP WKWRKKKSEK FKHTSAALER
60 70 80 90 100
KISMRQSREE LIKRGVLKEI YDKDGELSIS NEEDSLENGQ SLSSSQLSLP
110 120 130 140 150
ALSEMEPVPM PRDPCSYEVL QPSDIMDGPD PGAPVKLPCL PVKLSPPLPP
160 170 180 190 200
KKVMICMPVG GPDLSLVSYT AQKSGQQGVA QHHHTVLPSQ IQHQLQYGSH
210 220 230 240 250
GQHLPSTTGS LPMHPSGCRM IDELNKTLAM TMQRLESSEQ RVPCSTSYHS
260 270 280 290 300
SGLHSGDGVT KAGPMGLPEI RQVPTVVIEC DDNKENVPHE SDYEDSSCLY
310 320 330 340 350
TREEEEEEED EDDDSSLYTS SLAMKVCRKD SLAIKLSNRP SKRELEEKNI
360 370 380 390 400
LPRQTDEERL ELRQQIGTKL TRRLSQRPTA EELEQRNILK PRNEQEEQEE
410 420 430 440 450
KREIKRRLTR KLSQRPTVEE LRERKILIRF SDYVEVADAQ DYDRRADKPW
460 470 480
TRLTAADKAA IRKELNEFKS TEMEVHELSR HLTRFHRP
Length:488
Mass (Da):55,847
Last modified:October 29, 2014 - v2
Checksum:i22FE274EF41BE8E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC213202 Genomic DNA. No translation available.
AL008729 Genomic DNA. No translation available.
AL354680 Genomic DNA. No translation available.
AL391385 Genomic DNA. No translation available.
AL391837 Genomic DNA. No translation available.
AL591682 Genomic DNA. No translation available.
KF458098 Genomic DNA. No translation available.
KF458101 Genomic DNA. No translation available.
Z99495 Genomic DNA. No translation available.
UniGeneiHs.436996.

Genome annotation databases

EnsembliENST00000415087; ENSP00000395948; ENSG00000112137.
ENST00000635526; ENSP00000489396; ENSG00000282833.
UCSCiuc063lxl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC213202 Genomic DNA. No translation available.
AL008729 Genomic DNA. No translation available.
AL354680 Genomic DNA. No translation available.
AL391385 Genomic DNA. No translation available.
AL391837 Genomic DNA. No translation available.
AL591682 Genomic DNA. No translation available.
KF458098 Genomic DNA. No translation available.
KF458101 Genomic DNA. No translation available.
Z99495 Genomic DNA. No translation available.
UniGeneiHs.436996.

3D structure databases

ProteinModelPortaliH0Y518.
SMRiH0Y518. Positions 41-70, 327-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329880.

Proteomic databases

PaxDbiH0Y518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415087; ENSP00000395948; ENSG00000112137.
ENST00000635526; ENSP00000489396; ENSG00000282833.
UCSCiuc063lxl.1. human.

Organism-specific databases

CTDi221692.
HGNCiHGNC:20990. PHACTR1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMQP. Eukaryota.
ENOG411029R. LUCA.
GeneTreeiENSGT00390000004420.

Miscellaneous databases

ChiTaRSiPHACTR1. human.
GenomeRNAii221692.

Gene expression databases

ExpressionAtlasiH0Y518. baseline and differential.

Family and domain databases

InterProiIPR029987. Phactr1.
IPR004018. RPEL_repeat.
[Graphical view]
PANTHERiPTHR12751:SF6. PTHR12751:SF6. 1 hit.
PfamiPF02755. RPEL. 4 hits.
[Graphical view]
SMARTiSM00707. RPEL. 4 hits.
[Graphical view]
PROSITEiPS51073. RPEL. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (DEC-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH0Y518_HUMAN
AccessioniPrimary (citable) accession number: H0Y518
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 29, 2014
Last modified: June 8, 2016
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.