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Protein
Submitted name:

Nuclear autoantigen Sp-100

Gene

SP100

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Zinc 1Combined sources1
Metal bindingi82Zinc 1Combined sources1
Metal bindingi91Zinc 2Combined sources1
Metal bindingi94Zinc 2Combined sources1
Metal bindingi99Zinc 1; via pros nitrogenCombined sources1
Metal bindingi102Zinc 1Combined sources1
Metal bindingi116Zinc 2Combined sources1
Metal bindingi119Zinc 2Combined sources1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear autoantigen Sp-100Imported
Gene namesi
Name:SP100Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000067066.16.
HGNCiHGNC:11206. SP100.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067066.

PTM / Processingi

Proteomic databases

MaxQBiH0Y4R8.
PaxDbiH0Y4R8.
PeptideAtlasiH0Y4R8.
PRIDEiH0Y4R8.

Expressioni

Gene expression databases

BgeeiENSG00000067066.
ExpressionAtlasiH0Y4R8. baseline and differential.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5PWCX-ray1.55A/B74-253[»]
5PWDX-ray1.57A/B74-253[»]
ProteinModelPortaliH0Y4R8.
SMRiH0Y4R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SANDInterPro annotationAdd BLAST58
Domaini76 – 122PHD-typeInterPro annotationAdd BLAST47

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00510000046835.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR010919. SAND-like_dom_sf.
IPR000770. SAND_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00439. Bromodomain. 1 hit.
PF01342. SAND. 1 hit.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEiView protein in PROSITE
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0Y4R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XTLYKERFKQ GTSKKCIQSE DKKWFTPREF EIEGDRGASK NWKLSIRCGG
60 70 80 90 100
YTLKVLMERI LESHNNTLVD PCPENSNICE VCNKWGRLFC CDTCPRSFHE
110 120 130 140 150
HCHIPSVEAN KNPWSCIFCR IKTIQERCPE SQSGHQESEV LMRQMLPEEQ
160 170 180 190 200
LKCEFLLLKV YCDSKSCFFA SEPYYNREGS QGPQKPMWLN KVKTSLNEQM
210 220 230 240 250
YTRVEGFVQD MRLIFHNHKE FYREDKFTRL GIQVQDIFEK NFRNIFAIQE

TSKNIIMFI
Length:259
Mass (Da):30,730
Last modified:February 22, 2012 - v1
Checksum:i99E406A0DA7ECC75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009949 Genomic DNA. No translation available.
AC010149 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000431952; ENSP00000393679; ENSG00000067066.
UCSCiuc061tjw.1. human.

Similar proteinsi

Entry informationi

Entry nameiH0Y4R8_HUMAN
AccessioniPrimary (citable) accession number: H0Y4R8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported