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Protein
Submitted name:

Myeloid differentiation primary response protein MyD88

Gene

MYD88

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Myeloid differentiation primary response protein MyD88Imported
Gene namesi
Name:MYD88Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7562. MYD88.

PTM / Processingi

Proteomic databases

EPDiH0Y4G9.
PaxDbiH0Y4G9.
PRIDEiH0Y4G9.

Expressioni

Gene expression databases

BgeeiH0Y4G9.
ExpressionAtlasiH0Y4G9. baseline and differential.
GenevisibleiH0Y4G9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000401399.

Structurei

3D structure databases

ProteinModelPortaliH0Y4G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12178DeathInterPro annotationAdd
BLAST
Domaini171 – 316146TIRInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
OMAiRCKRMVV.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H0Y4G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RPDRAEAPGP PAMAAGGPGA GSAAPVSSTS SLPLAALNMR VRRRLSLFLN
60 70 80 90 100
VRTQVAADWT ALAEEMDFEY LEIRQLETQA DPTGRLLDAW QGRPGASVGR
110 120 130 140 150
LLELLTKLGR DDVLLELGPS IEEDCQKYIL KQQQEEAEKP LQVAAVDSSV
160 170 180 190 200
PRTAELAGIT TLDDPLGHMP ERFDAFICYC PSDIQFVQEM IRQLEQTNYR
210 220 230 240 250
LKLCVSDRDV LPGTCVWSIA SELIEKRLAR RPRGGCRRMV VVVSDDYLQS
260 270 280 290 300
KECDFQTKFA LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC
310
TKSWFWTRLA KALSLP
Length:316
Mass (Da):35,313
Last modified:February 22, 2012 - v1
Checksum:i11249F8778C047B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006309 Genomic DNA. No translation available.
UniGeneiHs.82116.

Genome annotation databases

EnsembliENST00000421516; ENSP00000391753; ENSG00000172936.
UCSCiuc062ifw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006309 Genomic DNA. No translation available.
UniGeneiHs.82116.

3D structure databases

ProteinModelPortaliH0Y4G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000401399.

Proteomic databases

EPDiH0Y4G9.
PaxDbiH0Y4G9.
PRIDEiH0Y4G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421516; ENSP00000391753; ENSG00000172936.
UCSCiuc062ifw.1. human.

Organism-specific databases

HGNCiHGNC:7562. MYD88.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
OMAiRCKRMVV.

Miscellaneous databases

ChiTaRSiMYD88. human.
NextBioi17764.

Gene expression databases

BgeeiH0Y4G9.
ExpressionAtlasiH0Y4G9. baseline and differential.
GenevisibleiH0Y4G9. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH0Y4G9_HUMAN
AccessioniPrimary (citable) accession number: H0Y4G9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 16, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.