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Protein
Submitted name:

Serine/threonine-protein kinase SIK3

Gene

SIK3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiH0Y494.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase SIK3Imported
Gene namesi
Name:SIK3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29165. SIK3.

PTM / Processingi

Proteomic databases

EPDiH0Y494.
MaxQBiH0Y494.

Expressioni

Gene expression databases

BgeeiH0Y494.
ExpressionAtlasiH0Y494. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH0Y494.
SMRiH0Y494. Positions 48-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 317252Protein kinaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili641 – 66828Sequence analysisAdd
BLAST
Coiled coili936 – 95823Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00790000122947.
KOiK19009.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H0Y494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP
60 70 80 90 100
PAPASRGPMP ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT
110 120 130 140 150
QLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI
160 170 180 190 200
FDHLVAHGRM AEKEARRKFK QIVTAVYFCH CRNIVHRDLK AENLLLDANL
210 220 230 240 250
NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG
260 270 280 290 300
VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL
310 320 330 340 350
DPNKRLSMEQ ICKHKWMKLG DADPNFDRLI AECQQLKEER QVDPLNEDVL
360 370 380 390 400
LAMEDMGLDK EQTLQAEQAG TAMNISVPQV QLINPENQIV EPDGTLNLDS
410 420 430 440 450
DEGEEPSPEA LVRYLSMRRH TVGVADPRTE VMEDLQKLLP GFPGVNPQAP
460 470 480 490 500
FLQVAPNVNF MHNLLPMQNL QPTGQLEYKE QSLLQPPTLQ LLNGMGPLGR
510 520 530 540 550
RASDGGANIQ LHAQQLLKRP RGPSPLVTMT PAVPAVTPVD EESSDGEPDQ
560 570 580 590 600
EAVQRYLANR SKRHTLAMTN PTAEIPPDLQ RQLGQQPFRS RVWPPHLVPD
610 620 630 640 650
QHRSTYKDSN TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KMGNNSSIKQ
660 670 680 690 700
LQQECEQLQK MYGGQIDERT LEKTQQQHML YQQEQHHQIL QQQIQDSICP
710 720 730 740 750
PQPSPPLQAA CENQPALLTH QLQRLRIQPS SPPPNHPNNH LFRQPSNSPP
760 770 780 790 800
PMSSAMIQPH GAASSSQFQG LPSRSAIFQQ QPENCSSPPN VALTCLGMQQ
810 820 830 840 850
PAQSQQVTIQ VQEPVDMLSN MPGTAAGSSG RGISISPSAG QMQMQHRTNL
860 870 880 890 900
MATLSYGHRP LSKQLSADSA EAHSAHQQPP HYTTSALQQA LLSPTPPDYT
910 920 930 940 950
RHQQVPHILQ GLLSPRHSLT GHSDIRLPPT EFAQLIKRQQ QQRQQQQQQQ
960 970 980 990 1000
QQQEYQELFR HMNQGDAGSL APSLGGQSMT ERQALSYQNA DSYHHHTSPQ
1010 1020 1030 1040 1050
HLLQIRAQEC VSQASSPTPP HGYAHQPALM HSESMEEDCS CEGAKDGFQD
1060 1070 1080 1090 1100
SKSSSTLTKG CHDSPLLLST GGPGDPESLL GTVSHAQELG IHPYGHQPTA
1110 1120 1130 1140 1150
AFSKNKVPSR EPVIGNCMDR SSPGQAVELP DHNGLGYPAR PSVHEHHRPR
1160 1170 1180 1190 1200
ALQRHHTIQN SDDAYVQLDN LPGMSLVAGK ALSSARMSDA VLSQSSLMGS
1210 1220 1230 1240 1250
QQFQDGENEE CGASLGGHEH PDLSDGSQHL NSSCYPSTCI TDILLSYKHP
1260
EVSFSMEQAG V
Length:1,261
Mass (Da):138,586
Last modified:February 22, 2012 - v1
Checksum:i36FE1ABFEB26690E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000936 Genomic DNA. No translation available.
AP003070 Genomic DNA. No translation available.
AP006216 Genomic DNA. No translation available.
RefSeqiNP_001268678.1. NM_001281749.1.
UniGeneiHs.167451.

Genome annotation databases

EnsembliENST00000446921; ENSP00000390442; ENSG00000160584.
GeneIDi23387.
KEGGihsa:23387.
UCSCiuc001pqa.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000936 Genomic DNA. No translation available.
AP003070 Genomic DNA. No translation available.
AP006216 Genomic DNA. No translation available.
RefSeqiNP_001268678.1. NM_001281749.1.
UniGeneiHs.167451.

3D structure databases

ProteinModelPortaliH0Y494.
SMRiH0Y494. Positions 48-422.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y494.
MaxQBiH0Y494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446921; ENSP00000390442; ENSG00000160584.
GeneIDi23387.
KEGGihsa:23387.
UCSCiuc001pqa.5. human.

Organism-specific databases

CTDi23387.
HGNCiHGNC:29165. SIK3.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00790000122947.
KOiK19009.

Enzyme and pathway databases

SignaLinkiH0Y494.

Miscellaneous databases

ChiTaRSiSIK3. human.
GenomeRNAii23387.

Gene expression databases

BgeeiH0Y494.
ExpressionAtlasiH0Y494. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH0Y494_HUMAN
AccessioniPrimary (citable) accession number: H0Y494
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 8, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.