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Protein
Submitted name:

Dystrophin

Gene

DMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiH0Y304.

Names & Taxonomyi

Protein namesi
Submitted name:
DystrophinImported
Gene namesi
Name:DMDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198947.15.
HGNCiHGNC:2928. DMD.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198947.

PTM / Processingi

Proteomic databases

EPDiH0Y304.
MaxQBiH0Y304.
PeptideAtlasiH0Y304.
PRIDEiH0Y304.

Expressioni

Gene expression databases

BgeeiENSG00000198947.
ExpressionAtlasiH0Y304. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0Y304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini751 – 784WWInterPro annotationAdd BLAST34
Domaini1003 – 1050ZZ-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 39Sequence analysisAdd BLAST28
Coiled coili99 – 119Sequence analysisAdd BLAST21
Coiled coili199 – 243Sequence analysisAdd BLAST45
Coiled coili250 – 270Sequence analysisAdd BLAST21
Coiled coili285 – 305Sequence analysisAdd BLAST21
Coiled coili618 – 652Sequence analysisAdd BLAST35
Coiled coili1179 – 1213Sequence analysisAdd BLAST35
Coiled coili1252 – 1286Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4286. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000119237.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR016344. Dystrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR036020. WW_dom_sf.
IPR000433. Znf_ZZ.
PANTHERiPTHR44318:SF1. PTHR44318:SF1. 1 hit.
PfamiView protein in Pfam
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 4 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
SMARTiView protein in SMART
SM00150. SPEC. 5 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

H0Y304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VSRALPEKQG EIEAQIKDLG QLEKKLEDLE EQLNHLLLWL SPIRNQLEIY
60 70 80 90 100
NQPNQEGPFD VKETEIAVQA KQPDVEEILS KGQHLYKEKP ATQPVKRKLE
110 120 130 140 150
DLSSEWKAVN RLLQELRAKQ PDLAPGLTTI GASPTQTVTL VTQPVVTKET
160 170 180 190 200
AISKLEMPSS LMLEVPALAD FNRAWTELTD WLSLLDQVIK SQRVMVGDLE
210 220 230 240 250
DINEMIIKQK ATMQDLEQRR PQLEELITAA QNLKNKTSNQ EARTIITDRI
260 270 280 290 300
ERIQNQWDEV QEHLQNRRQQ LNEMLKDSTQ WLEAKEEAEQ VLGQARAKLE
310 320 330 340 350
SWKEGPYTVD AIQKKITETK QLAKDLRQWQ TNVDVANDLA LKLLRDYSAD
360 370 380 390 400
DTRKVHMITE NINASWRSIH KRVSEREAAL EETHRLLQQF PLDLEKFLAW
410 420 430 440 450
LTEAETTANV LQDATRKERL LEDSKGVKEL MKQWQDLQGE IEAHTDVYHN
460 470 480 490 500
LDENSQKILR SLEGSDDAVL LQRRLDNMNF KWSELRKKSL NIRSHLEASS
510 520 530 540 550
DQWKRLHLSL QELLVWLQLK DDELSRQAPI GGDFPAVQKQ NDVHRAFKRE
560 570 580 590 600
LKTKEPVIMS TLETVRIFLT EQPLEGLEKL YQEPRELPPE ERAQNVTRLL
610 620 630 640 650
RKQAEEVNTE WEKLNLHSAD WQRKIDETLE RLRELQEATD ELDLKLRQAE
660 670 680 690 700
VIKGSWQPVG DLLIDSLQDH LEKVKALRGE IAPLKENVSH VNDLARQLTT
710 720 730 740 750
LGIQLSPYNL STLEDLNTRW KLLQVAVEDR VRQLHEAHRD FGPASQHFLS
760 770 780 790 800
TSVQGPWERA ISPNKVPYYI NHETQTTCWD HPKMTELYQS LADLNNVRFS
810 820 830 840 850
AYRTAMKLRR LQKALCLDLL SLSAACDALD QHNLKQNDQP MDILQIINCL
860 870 880 890 900
TTIYDRLEQE HNNLVNVPLC VDMCLNWLLN VYDTGRTGRI RVLSFKTGII
910 920 930 940 950
SLCKAHLEDK YRYLFKQVAS STGFCDQRRL GLLLHDSIQI PRQLGEVASF
960 970 980 990 1000
GGSNIEPSVR SCFQFANNKP EIEAALFLDW MRLEPQSMVW LPVLHRVAAA
1010 1020 1030 1040 1050
ETAKHQAKCN ICKECPIIGF RYRSLKHFNY DICQSCFFSG RVAKGHKMHY
1060 1070 1080 1090 1100
PMVEYCTPTT SGEDVRDFAK VLKNKFRTKR YFAKHPRMGY LPVQTVLEGD
1110 1120 1130 1140 1150
NMETPASSPQ LSHDDTHSRI EHYASRLAEM ENSNGSYLND SISPNESIDD
1160 1170 1180 1190 1200
EHLLIQHYCQ SLNQDSPLSQ PRSPAQILIS LESEERGELE RILADLEEEN
1210 1220 1230 1240 1250
RNLQAEYDRL KQQHEHKGLS PLPSPPEMMP TSPQSPRDAE LIAEAKLLRQ
1260 1270 1280 1290 1300
HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPQAEAKVN GTTVSSPSTS
1310 1320 1330 1340 1350
LQRSDSSQPM LLRVVGSQTS DSMGEEDLLS PPQDTSTGLE EVMEQLNNSF
1360 1370 1380
PSSRGHNVGS LFHMADDLGR AMESLVSVMT DEEGAE
Length:1,386
Mass (Da):159,362
Last modified:February 22, 2012 - v1
Checksum:i428391C4D801D5D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006061 Genomic DNA. No translation available.
AC078957 Genomic DNA. No translation available.
AC078958 Genomic DNA. No translation available.
AC079143 Genomic DNA. No translation available.
AC079175 Genomic DNA. No translation available.
AC079177 Genomic DNA. No translation available.
AC079864 Genomic DNA. No translation available.
AC090632 Genomic DNA. No translation available.
AC093167 Genomic DNA. No translation available.
AC093193 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000358062; ENSP00000350765; ENSG00000198947.
UCSCiuc064ylu.1. human.

Similar proteinsi

Entry informationi

Entry nameiH0Y304_HUMAN
AccessioniPrimary (citable) accession number: H0Y304
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 31, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported