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Protein
Submitted name:

Thrombomodulin

Gene

THBD

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:THBDImported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei519 – 541HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500354599617 – 577Sequence analysisAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi442 ↔ 452PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000018555.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 158C-type lectinInterPro annotationAdd BLAST128
Domaini322 – 358EGF-likeInterPro annotationAdd BLAST37
Domaini362 – 402EGF-likeInterPro annotationAdd BLAST41
Domaini438 – 478EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
InParanoidiH0XR13.
OMAiLCGPLCV.
OrthoDBiEOG091G06M1.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR016316. CD141.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_cys_sf.
IPR015149. Tme5_EGF-like.
PANTHERiPTHR24036:SF5. PTHR24036:SF5. 1 hit.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

H0XR13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVLLLGVL APAGLGIPTP AEPQPRGSQC VEHDCFALFR GPATFLAASQ
60 70 80 90 100
VCERLQGHLM TVRSSVAADV ISLLLNSDGG DSPRLWIGLK LPAGCRDPGH
110 120 130 140 150
LGSLRGFQWV TGDNRTSYSR WARLDHSREP LCGPLCVTVS AAGASAPGEP
160 170 180 190 200
AWQEQQCDAE THGFLCEFHF PTSCRPLEVK HGAQAAASVS ITYSTPFGAR
210 220 230 240 250
GADFQALPAG STAAVAPLGL ELVCSAPPGA AGEARWVREK PGAWPCGVEN
260 270 280 290 300
GGCERVCNDS SGVPSCFCPG DAALQADGRS CAASCNDLCE HLCFPDPNVP
310 320 330 340 350
GSYSCMCETG YQLAADQHRC EDVDDCMLVP SPCPQRCINT QGGFECLCHP
360 370 380 390 400
GYELVDGECV EAVDPCFAAN CEYQCQPVGP TNYTCICAEG FVPKPQEPSR
410 420 430 440 450
CQMFCNQTSC PADCDPNTPA DCKCPEGYIL DEGSVCTDID ECYNDYCHGG
460 470 480 490 500
QCRNLPGSYE CVCGPDSVLA GQVSKDCSPI EVNGQNTGVE DGGSGEIPVS
510 520 530 540 550
PTPSSTSGPP AAGQVHSGVL MGISIASLSL VVALLALLCH LRKKQGTARA
560 570
KTEYKPAAPA KEAALQQVRT ERTPQTL
Length:577
Mass (Da):60,544
Last modified:February 22, 2012 - v1
Checksum:iD987763684AB6535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03145741 Genomic DNA. No translation available.
RefSeqiXP_003803986.2. XM_003803938.2.

Genome annotation databases

EnsembliENSOGAT00000032779; ENSOGAP00000018555; ENSOGAG00000026061.
GeneIDi100951808.

Similar proteinsi

Entry informationi

Entry nameiH0XR13_OTOGA
AccessioniPrimary (citable) accession number: H0XR13
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 22, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported