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Protein

Claudin

Gene

CLDN3

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN3Imported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 29HelicalUniRule annotationAdd BLAST18
Transmembranei78 – 104HelicalUniRule annotationAdd BLAST27
Transmembranei116 – 139HelicalUniRule annotationAdd BLAST24
Transmembranei159 – 182HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000015632.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
InParanoidiH0XHP2.
OMAiLCTIVCC.
OrthoDBiEOG091G0MMR.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01378. CLAUDIN3.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

H0XHP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEITGT SLAVLGWLGT IVCCALPMWR VSAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVAILVA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPEAQKREMG AGLYVGWAAA GLQLLGGALL CCSCPPREKK YQPAKVLYSA
210 220
PRSAGPAPAA STAYDRKDYV
Length:220
Mass (Da):23,330
Last modified:February 22, 2012 - v1
Checksum:i236403D811EFC7D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03108281 Genomic DNA. No translation available.
RefSeqiXP_003794247.1. XM_003794199.2.

Genome annotation databases

EnsembliENSOGAT00000024490; ENSOGAP00000015632; ENSOGAG00000033364.
GeneIDi100945481.

Similar proteinsi

Entry informationi

Entry nameiH0XHP2_OTOGA
AccessioniPrimary (citable) accession number: H0XHP2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported