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Protein

Aminopeptidase

Gene

ERAP1

Organism
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM01.018

Names & Taxonomyi

Protein namesi
Recommended name:
AminopeptidaseUniRule annotation (EC:3.4.11.-UniRule annotation)
Gene namesi
Name:ERAP1Imported
OrganismiOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)Imported
Taxonomic identifieri30611 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur
Proteomesi
  • UP000005225 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500354378633 – 942AminopeptidaseSequence analysisAdd BLAST910

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi30611.ENSOGAP00000003669

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 525Peptidase_M1InterPro annotationAdd BLAST261
Domaini598 – 917ERAP1_CInterPro annotationAdd BLAST320

Sequence similaritiesi

Belongs to the peptidase M1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1046 Eukaryota
COG0308 LUCA
GeneTreeiENSGT00760000119082
InParanoidiH0WP75
OMAiDTGYLWH
OrthoDBiEOG091G01GH
TreeFamiTF300395

Family and domain databases

CDDicd09601 M1_APN_2, 1 hit
InterProiView protein in InterPro
IPR033520 ERAP1
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
PANTHERiPTHR11533 PTHR11533, 1 hit
PTHR11533:SF156 PTHR11533:SF156, 1 hit
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE

Sequencei

Sequence statusi: Complete.

H0WP75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLSFRWPP AVLSCLLPSL VTLLTVSTPS WCQNSEAASP EGPDGTPFPW
60 70 80 90 100
SKMRLPEHVI PVHYDLMIHA NLTTLTFWGT VQVEIAVSQP TTAIILHGHR
110 120 130 140 150
LQVSEATLRR GAREQLSAEP LRVLEHPPHE QIALLAPEPL LAGLPYTVVI
160 170 180 190 200
KYAGNLSENF HGFYKSTYRT KEGEVRILAS TQFEPTAARM AFPCFDEPAL
210 220 230 240 250
KARFSIKIRR EPRHLAISNM PLVKSVTISG GLIEDHFDVT VKMSTYLVAF
260 270 280 290 300
IISDFESVSK MTKSGIKVSV YAVPDKIHQA NYALGAAVTL LEFYEDYFQI
310 320 330 340 350
PYPLPKQDLA AIPDFQSGAM ENWGLTTYRE SSLLFDAEKS SVSSKLAVTM
360 370 380 390 400
TVAHELAHQW FGNLVTMEWW NDLWLNEGFA KFMEFVSVSV THPELKVEDY
410 420 430 440 450
FFGKCFNVME VDALNSSHPV STPVENPAQI QEMFDDVSYE KGACILNMLR
460 470 480 490 500
DYLSAHVFKS GIIRYLQKYS YKNTKNEDLW NSMTSICPTD DPQNVDGFCP
510 520 530 540 550
GDQHSSSSSH WRQEGLDVQA MMDTWTLQKG FPLITVMVRG RNVYLEQQHY
560 570 580 590 600
MKASDDAPET GYLWHVPLTF ITSKSDTVHR FLLKAKTDVL ILPQEVEWIK
610 620 630 640 650
FNVGMNGYYI VHYEGDGWDS LTGLLKGTHR AISSQDRASL IHNAFQLASI
660 670 680 690 700
GKLSIEKALD LALYLKRETE ILPVFQGLNE LILIYKLMEK RDMNEVETQF
710 720 730 740 750
KAFLIKLLRD LIDRQAWTDE GSVTERMLRS RLLLLACVRG YQPCVQRAEG
760 770 780 790 800
YFRRWKESGG NLSLPNDVTL AVFAVGAQNT EGWDFLYSKY QSSLSSAEKE
810 820 830 840 850
QIEFALCMSQ KKDKLQWLLD QSFKGDIIKT QEFPGILILI GRNPVGYPLA
860 870 880 890 900
WQFLRENWNK LVQKFELGSP SIAHMVMGTT NQFSTRTRLE EVKGFFSSLK
910 920 930 940
ENGSQLRCVQ QTIETIEENI RWMDKNFDKI RVWLQNEKLE LL
Length:942
Mass (Da):107,400
Last modified:February 22, 2012 - v1
Checksum:iD3CD4D84D6640FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAQR03154692 Genomic DNA No translation available.
AAQR03154693 Genomic DNA No translation available.
RefSeqiXP_003799752.1, XM_003799704.2

Genome annotation databases

EnsembliENSOGAT00000004116; ENSOGAP00000003669; ENSOGAG00000004114
GeneIDi100956331

Similar proteinsi

Entry informationi

Entry nameiH0WP75_OTOGA
AccessioniPrimary (citable) accession number: H0WP75
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health