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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

PTPN6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei439SubstrateUniRule annotation1
Active sitei473Phosphocysteine intermediateUniRule annotation1
Binding sitei520SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN6Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSCPOG00000008887.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007982.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 120SH2InterPro annotationAdd BLAST97
Domaini130 – 233SH2InterPro annotationAdd BLAST104
Domaini264 – 535Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini450 – 526TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00880000137849.
InParanoidiH0VDD2.
OMAiQAKGEPW.
OrthoDBiEOG091G0VZ3.
TreeFamiTF351632.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR000980. SH2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 2 hits.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

H0VDD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AWTSRTSSFP APPSSPGAPR MVRWFHRDLS GLDAETLLKG RGVDGSFLAR
60 70 80 90 100
PSRKNQGDFS LSVRVGDQVT HIRIQNTGDF YDLYGGEKFA TLTELVEYYT
110 120 130 140 150
QQQAVLQDRD GTIIHLKYPL NCSDPTSERW YHGHMSGIQA EALLQAKGEP
160 170 180 190 200
WTFLVRESLS QPGDFVLSVL SDQPKAGVGS PLKVTHIKVM CEGERYTVGG
210 220 230 240 250
SEIFDNLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL
260 270 280 290 300
NKKKESEDTA KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL
310 320 330 340 350
PFDHTRVILQ GRDSNIPGSD YINANYVKNK LLGPDENSKT YIASQGCLEA
360 370 380 390 400
TVNDFWQMAW QENTRVIVMT TREVEKGRNK CVPYWPEVGS QRAYGPYSVT
410 420 430 440 450
NCGEHDAAEY KLRTLQVSPL DNGDLIREIW HYQYLSWPDH GVPSEPGGVL
460 470 480 490 500
SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ESISTKGLDC
510 520 530 540 550
DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEVMQSQK
560 570 580 590 600
GQESEYGNIT YPPAMKSAHA KASRTSSKHK EDVYENLHGK SKKEEKVKKQ
610
QSADKEKSKG SLKRK
Length:615
Mass (Da):69,484
Last modified:February 22, 2012 - v1
Checksum:iF6E98DE71A746202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02051612 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCPOT00000008967; ENSCPOP00000007982; ENSCPOG00000008887.

Similar proteinsi

Entry informationi

Entry nameiH0VDD2_CAVPO
AccessioniPrimary (citable) accession number: H0VDD2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 27, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported