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Protein
Submitted name:

Protein tyrosine phosphatase, non-receptor type 6

Gene

PTPN6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei380SubstrateUniRule annotation1
Active sitei414Phosphocysteine intermediateUniRule annotation1
Binding sitei461SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, non-receptor type 6Imported
Gene namesi
Name:PTPN6Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Expressioni

Gene expression databases

BgeeiENSCPOG00000008887

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007982

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH2InterPro annotationAdd BLAST61
Domaini71 – 174SH2InterPro annotationAdd BLAST104
Domaini205 – 476Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini391 – 467TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
InParanoidiH0VDD2
OrthoDBiEOG091G0VZ3
TreeFamiTF351632

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

H0VDD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSGVGDQV THIRIQNTGD FYDLYGGEKF ATLTELVEYY TQQQAVLQDR
60 70 80 90 100
DGTIIHLKYP LNCSDPTSER WYHGHMSGIQ AEALLQAKGE PWTFLVRESL
110 120 130 140 150
SQPGDFVLSV LSDQPKAGVG SPLKVTHIKV MCEGERYTVG GSEIFDNLTD
160 170 180 190 200
LVEHFKKTGI EEASGAFVYL RQPYYATRVN AADIENRVLE LNKKKESEDT
210 220 230 240 250
AKAGFWEEFE SLQKQEVKNL HQRLEGQRPE NKSKNRYKNI LPFDHTRVIL
260 270 280 290 300
QGRDSNIPGS DYINANYVKN KLLGPDENSK TYIASQGCLE ATVNDFWQMA
310 320 330 340 350
WQENTRVIVM TTREVEKGRN KCVPYWPEVG SQRAYGPYSV TNCGEHDAAE
360 370 380 390 400
YKLRTLQVSP LDNGDLIREI WHYQYLSWPD HGVPSEPGGV LSFLDQINQR
410 420 430 440 450
QESLPHAGPI IVHCSAGIGR TGTIIVIDML MESISTKGLD CDIDIQKTIQ
460 470 480 490 500
MVRAQRSGMV QTEAQYKFIY VAIAQFIETT KKKLEVMQSQ KGQESEYGNI
510 520 530 540 550
TYPPAMKSAH AKASRTSSKH KEDVYENLHG KSKKEEKVKK QQSADKEKSK

GSLKRK
Length:556
Mass (Da):62,962
Last modified:November 22, 2017 - v2
Checksum:i089878698756BE04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02051612 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCPOT00000008967; ENSCPOP00000007982; ENSCPOG00000008887

Similar proteinsi

Entry informationi

Entry nameiH0VDD2_CAVPO
AccessioniPrimary (citable) accession number: H0VDD2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 22, 2017
Last modified: June 20, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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