Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase non-receptor type

Gene

PTPN6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN6Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSCPOG00000008887.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007982.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.
InParanoidiH0VDD2.
OMAiQAKGEPW.
OrthoDBiEOG091G0VZ3.
TreeFamiTF351632.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 2 hits.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

H0VDD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSGVGDQV THIRIQNTGD FYDLYGGEKF ATLTELVEYY TQQQAVLQDR
60 70 80 90 100
DGTIIHLKYP LNCSDPTSER WYHGHMSGIQ AEALLQAKGE PWTFLVRESL
110 120 130 140 150
SQPGDFVLSV LSDQPKAGVG SPLKVTHIKV MCEGERYTVG GSEIFDNLTD
160 170 180 190 200
LVEHFKKTGI EEASGAFVYL RQPYYATRVN AADIENRVLE LNKKKESEDT
210 220 230 240 250
AKAGFWEEFE SLQKQEVKNL HQRLEGQRPE NKSKNRYKNI LPFDHTRVIL
260 270 280 290 300
QGRDSNIPGS DYINANYVKN KLLGPDENSK TYIASQGCLE ATVNDFWQMA
310 320 330 340 350
WQENTRVIVM TTREVEKGRN KCVPYWPEVG SQRAYGPYSV TNCGEHDAAE
360 370 380 390 400
YKLRTLQVSP LDNGDLIREI WHYQYLSWPD HGVPSEPGGV LSFLDQINQR
410 420 430 440 450
QESLPHAGPI IVHCSAGIGR TGTIIVIDML MESISTKGLD CDIDIQKTIQ
460 470 480 490 500
MVRAQRSGMV QTEAQYKFIY VAIAQFIETT KKKLEVMQSQ KGQESEYGNI
510 520 530 540 550
TYPPAMKSAH AKASRTSSKH KEDVYENLHG KSKKEEKVKK QQSADKEKSK

GSLKRK
Length:556
Mass (Da):62,962
Last modified:November 22, 2017 - v2
Checksum:i089878698756BE04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02051612 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCPOT00000008967; ENSCPOP00000007982; ENSCPOG00000008887.

Similar proteinsi

Entry informationi

Entry nameiH0VDD2_CAVPO
AccessioniPrimary (citable) accession number: H0VDD2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: November 22, 2017
Last modified: November 22, 2017
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported