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H0NW58 (H0NW58_BACCE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP-Rule MF_00487
EC=1.1.1.37 HAMAP-Rule MF_00487
Gene names
Name:mdh HAMAP-Rule MF_00487
ORF Names:BCN_4493 EMBL BAL20286.1
OrganismBacillus cereus NC7401 EMBL BAL20286.1
Taxonomic identifier334406 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group ›

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. SAAS SAAS011275 HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. SAAS SAAS011275 HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family. HAMAP-Rule MF_00487

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 176NAD By similarity HAMAP-Rule MF_00487
Nucleotide binding123 – 1253NAD By similarity HAMAP-Rule MF_00487

Sites

Active site1801Proton acceptor By similarity HAMAP-Rule MF_00487
Binding site361NAD By similarity HAMAP-Rule MF_00487
Binding site871Substrate By similarity HAMAP-Rule MF_00487
Binding site931Substrate By similarity HAMAP-Rule MF_00487
Binding site1001NAD By similarity HAMAP-Rule MF_00487
Binding site1251Substrate By similarity HAMAP-Rule MF_00487
Binding site1561Substrate By similarity HAMAP-Rule MF_00487

Amino acid modifications

Modified residue1491Phosphoserine By similarity HAMAP-Rule MF_00487

Sequences

Sequence LengthMass (Da)Tools
H0NW58 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 615A61C61CA217FD

FASTA31233,498
        10         20         30         40         50         60 
MTIKRKKVSV IGAGFTGATT AFLLAQKELA DVVLVDIPQL ENPTKGKALD MLEASPVQGF 

        70         80         90        100        110        120 
DANIIGTSDY ADTADSDVVV ITAGIARKPG MSRDDLVATN SKIMKSITRD IAKHSPNAII 

       130        140        150        160        170        180 
VVLTNPVDAM TYSVFKEAGF PKERVIGQSG VLDTARFRTF IAQELNLSVK DITGFVLGGH 

       190        200        210        220        230        240 
GDDMVPLVRY SYAGGIPLET LIPKERLEAI VERTRKGGGE IVGLLGNGSA YYAPAASLVE 

       250        260        270        280        290        300 
MTEAILKDQR RVLPAIAYLE GEYGYSDLYL GVPVILGGNG IEKIIELELL ADEKEALDRS 

       310 
VESVRNVMKV LV

« Hide

References

[1]"Complete Genome Sequence of Bacillus cereus NC7401, Which Produces High Levels of the Emetic Toxin Cereulide."
Takeno A., Okamoto A., Tori K., Oshima K., Hirakawa H., Toh H., Agata N., Yamada K., Ogasawara N., Hayashi T., Shimizu T., Kuhara S., Hattori M., Ohta M.
J. Bacteriol. 194:4767-4768(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NC7401 EMBL BAL20286.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP007209 Genomic DNA. Translation: BAL20286.1.
RefSeqYP_005107026.1. NC_016771.1.

3D structure databases

ProteinModelPortalH0NW58.
SMRH0NW58. Positions 5-309.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAL20286; BAL20286; BCN_4493.
GeneID11688767.
KEGGbnc:BCN_4493.

Phylogenomic databases

KOK00024.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH0NW58_BACCE
AccessionPrimary (citable) accession number: H0NW58
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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