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Protein

5'-3' exoribonuclease 1

Gene

VIN7_1655

Organism
Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotation, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
ORF Names:VIN7_1655Imported
OrganismiSaccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7) (Yeast)Imported
Taxonomic identifieri1095631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000009009 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 227XRN_NInterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

PhylomeDBiH0GG41.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiView protein in InterPro
IPR027073. 5_3_exoribonuclease.
IPR016494. 5_3_exoribonuclease_1.
IPR029060. PIN_domain-like.
IPR004859. Put_53exo.
PANTHERiPTHR12341. PTHR12341. 1 hit.
PfamiView protein in Pfam
PF03159. XRN_N. 1 hit.
PIRSFiPIRSF006743. Exonuclease_Xnr1. 1 hit.

Sequencei

Sequence statusi: Complete.

H0GG41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIPKFFRYI SERWPMILQL IEGTQIPEFD NLYLDMNSIL HNCTHGNDDD
60 70 80 90 100
VTKRLTEEEV FAKICTYIDH LFQTIKPKKI FYMAIDGVAP RAKMNQQRAR
110 120 130 140 150
RFRTAMDAEK ALKKAIENGD EIPKGEPFDS NSITPGTEFM AKLTKNLQYF
160 170 180 190 200
IHDKISNDSK WREVQIIFSG HEVPGEGEHK IMNFIRHLKS QKDFNQNTRH
210 220 230 240 250
CIYGLDADLI MLGLSTHGPH FALLREEVTF GRRNSEKKSL EHQNFYLLHL
260 270 280 290 300
SLLREYMELE FKEIADEMQF EYNFERILDD FILVMFVIGN DFLPNLPDLH
310 320 330 340 350
LNKGAFPVLL QTFKEALLHT DGYINEHGKI NLKRLGVWLN YLSQFELLNF
360 370 380 390 400
EKDDIDVEWF NKQLENISLE GERKRQRVGK KLLVKQQKKL IGSIKPWLME
410 420 430 440 450
QLQEKLSPDL PDEEIPTLEL PKDLDMKDHL EFLKEFAFDL GLFITHSKSK
460 470 480 490 500
GSYSLKMDLD SINPDETEEE FQNRVNSIRK TIKKYQNAII VEDKEELETE
510 520 530 540 550
KTIYNERFER WKHEYYHDKL KFTTDSEEKV RDLAKDYVEG LQWVLYYYYR
560 570 580 590 600
GCPSWSWYYP HHYAPRISDL VKGLDQDIEF DLSKPFTPFQ QLMAVLPERS
610 620 630 640 650
KNLIPPAFRP LMYDEQSPIH DFYPAEVQLD KNGKTADWEA VVLISFVDEK
660 670 680 690 700
RLIEAMQPYL CKLSPEEKTR NQFGKDLIYS FNPQVDNIYK SPLGGIFSDI
710 720 730 740 750
EHNHCVEKEY ITIPLDSSEI RYGLLPNAKL GAEMLAGFPT LLSLPFTSSL
760 770 780 790 800
EYNETMVFQQ PSKQQSMVLQ ITDIYKTNNV TLEDFSKRHL NKVIYTRWPY
810 820 830 840 850
LRESKLVSLT DGKTIYEYQE SNDKKKFRFI TKPAETQDKK LFNSLKNSML
860 870 880 890 900
RMYAKQKAVK IGPVEAIATV FPVTGLVRDS DGGYIKTFSP TPDYYPLQLV
910 920 930 940 950
VESVVNEDER YKERGPIPIE EEFPLNSKVI FLGDYAYGGE TTIDGYSSDR
960 970 980 990 1000
RLKITVEKKF LDSEPTIGKE RLQMDHQAVK YYPSYTVSKN MHLHPLFLSK
1010 1020 1030 1040 1050
ITSKFMITDA TGKHINVGIP VKFEARHQKV LGYARRNPRG WEYSNLTLNL
1060 1070 1080 1090 1100
LKEYRQTFPD FFFRLSKVGN DIPVLEDLFP DTSTKDAMNL LDGIKQWLKY
1110 1120 1130 1140 1150
VSSKFIAVSL ESDSLTKTSI AAVEDHIMKY AANIEGHERK QLAKVPREAV
1160 1170 1180 1190 1200
LNPRSSFALL RSQKFDLGDR VVYIQDSGKV PIFSKGTVVG YTTLSSSLSI
1210 1220 1230 1240 1250
QVLFDHEIVA GNNFGGRLRT NRGLGLDASF LLNITNRQFI YHSKASKKAL
1260 1270 1280 1290 1300
EKKKQSNNRN NNTKTAHKTP SKQQSEEKLR KERAHDLLNF IKKDTNEKNS
1310 1320 1330 1340 1350
ESVDNKSMGS QKDSKPAKKV LLKRPAQKSS ENVQVGLANF EKAPLDNPTV
1360 1370 1380 1390 1400
AGSIFNAVAN QYSDGIGSNL NIPTPPHPMN VVGGPIPGAN DVADVGLPYN
1410 1420 1430 1440 1450
IPPGFMTHPN GLHPLHPHQM PYPNMNEMSI PPPAPHGFGQ PIPFPPPPPM
1460 1470 1480 1490 1500
TNVSDQGSRI VVNEKESQDL KKFINGKQHS NGSTIGGETK NSRKGEIKPS
1510 1520
SGTNSTECQS PKSQSNAADR DNKKDEST
Length:1,528
Mass (Da):175,514
Last modified:February 22, 2012 - v1
Checksum:i7AFAB9A70FF79B49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGVY01000022 Genomic DNA. Translation: EHN07281.1.

Genome annotation databases

EnsemblFungiiEHN07281; EHN07281; VIN7_1655.

Similar proteinsi

Entry informationi

Entry nameiH0GG41_SACCK
AccessioniPrimary (citable) accession number: H0GG41
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported