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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

ND4

Organism
Leucoraja erinacea (Little skate) (Raja erinacea)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:ND4Imported
Encoded oniMitochondrionImported
OrganismiLeucoraja erinacea (Little skate) (Raja erinacea)Imported
Taxonomic identifieri7782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaRajiformesRajidaeLeucoraja

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 42HelicalSequence analysisAdd BLAST22
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei94 – 111HelicalSequence analysisAdd BLAST18
Transmembranei117 – 134HelicalSequence analysisAdd BLAST18
Transmembranei146 – 168HelicalSequence analysisAdd BLAST23
Transmembranei195 – 217HelicalSequence analysisAdd BLAST23
Transmembranei229 – 252HelicalSequence analysisAdd BLAST24
Transmembranei258 – 279HelicalSequence analysisAdd BLAST22
Transmembranei286 – 304HelicalSequence analysisAdd BLAST19
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei351 – 370HelicalSequence analysisAdd BLAST20
Transmembranei390 – 415HelicalSequence analysisAdd BLAST26
Transmembranei436 – 458HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110Oxidored_q5_NInterPro annotationAdd BLAST110
Domaini113 – 404Proton_antipo_MInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
PANTHERiPTHR43507. PTHR43507. 1 hit.
PfamiView protein in Pfam
PF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

G9L9I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKILIPTLL LFPVSWIAPQ KWMWTSTISN SLLIAALSLT WFKWDFEMGW
60 70 80 90 100
NYSNLFLGVD PLSAPLLALT CWLLPLMLLA SLKHLTTEPH KRQQIYISLL
110 120 130 140 150
ITLQALLIMA FSATEMILFY VMFEATLIPT LIIITRWGNQ TERLNAGIYF
160 170 180 190 200
LFYTLAGSLP LLIALLVLQK DLGTLSMLIL QYPNTYNPHS WASKFWWAAC
210 220 230 240 250
LIAFLVKMPL YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRIIVM
260 270 280 290 300
LNPLTKEMAY PFLILAIWGI IMTSSICLRQ TDLKSLIAYS SVSHMGLVAA
310 320 330 340 350
AILIQTPWSF AGATALMIAH GLVSSMLFCL ANTNYERIHS RTLLLARGTQ
360 370 380 390 400
IILPLMGTSW FLANLANLAL PPSPNLMGEL LIISSLFKWS NWTIILTGTG
410 420 430 440 450
VLLTASYSLY MFLMTQRGPT PQHLLFLTPS HTREHLLMYL HLLPTILLIT
460
KPELILGWTF
Length:460
Mass (Da):51,734
Last modified:February 22, 2012 - v1
Checksum:i2AA83BFFADBA73CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ034406 Genomic DNA. Translation: AET87638.1.
RefSeqiYP_004935527.1. NC_016429.1.

Genome annotation databases

GeneIDi11452187.

Similar proteinsi

Entry informationi

Entry nameiG9L9I8_LEUER
AccessioniPrimary (citable) accession number: G9L9I8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)