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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Leucoraja erinacea (Little skate) (Raja erinacea)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotationSAAS annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COX1Imported
Encoded oniMitochondrionImported
OrganismiLeucoraja erinacea (Little skate) (Raja erinacea)Imported
Taxonomic identifieri7782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaRajiformesRajidaeLeucoraja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Transmembranei57 – 83HelicalSequence analysisAdd BLAST27
Transmembranei104 – 128HelicalSequence analysisAdd BLAST25
Transmembranei148 – 171HelicalSequence analysisAdd BLAST24
Transmembranei183 – 210HelicalSequence analysisAdd BLAST28
Transmembranei243 – 261HelicalSequence analysisAdd BLAST19
Transmembranei268 – 291HelicalSequence analysisAdd BLAST24
Transmembranei303 – 326HelicalSequence analysisAdd BLAST24
Transmembranei338 – 359HelicalSequence analysisAdd BLAST22
Transmembranei379 – 400HelicalSequence analysisAdd BLAST22
Transmembranei412 – 430HelicalSequence analysisAdd BLAST19
Transmembranei450 – 473HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 518COX1InterPro annotationAdd BLAST518

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiView protein in InterPro
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR036927. Cyt_c_oxase-like_su1_sf.
IPR000883. Cyt_C_Oxase_1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiView protein in Pfam
PF00115. COX1. 1 hit.
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiView protein in PROSITE
PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.

Sequencei

Sequence statusi: Complete.

G9L9I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAINRWLFST NHKDIGTLYL IFGAWAGMVG TGLSLLIRAE LSQPGSLLGD
60 70 80 90 100
DQIYNVLVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGSP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSFL LLLASAGVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGISSILA SINFITTIIN MKPPAISQYQ TPLFVWSILV TTVLLLMALP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHVVAY YSGKKEPFGY MGMVWAMMAI GLLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG SIKWETPLLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF
410 420 430 440 450
TGYTLHSTWA KIQFSIMFIG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW
460 470 480 490 500
NVVSSIGSLI SLVAVIILLF IIWEAFASKR EVLSIELSNT NVEWLHGCPP
510
PYHTYEEPAF VQVQQPAY
Length:518
Mass (Da):57,204
Last modified:February 22, 2012 - v1
Checksum:i2C47474EBF9AF8C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ034406 Genomic DNA. Translation: AET87631.1.
RefSeqiYP_004935520.1. NC_016429.1.

Genome annotation databases

GeneIDi11452180.

Similar proteinsi

Entry informationi

Entry nameiG9L9I1_LEUER
AccessioniPrimary (citable) accession number: G9L9I1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 25, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)