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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

ND2

Organism
Leucoraja erinacea (Little skate) (Raja erinacea)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transport, Respiratory chainSAAS annotation, Transport
LigandNADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotationSAAS annotation)
Gene namesi
Name:ND2Imported
Encoded oniMitochondrionImported
OrganismiLeucoraja erinacea (Little skate) (Raja erinacea)Imported
Taxonomic identifieri7782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaRajiformesRajidaeLeucoraja

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 75HelicalSequence analysisAdd BLAST19
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei152 – 171HelicalSequence analysisAdd BLAST20
Transmembranei178 – 197HelicalSequence analysisAdd BLAST20
Transmembranei203 – 222HelicalSequence analysisAdd BLAST20
Transmembranei234 – 255HelicalSequence analysisAdd BLAST22
Transmembranei275 – 294HelicalSequence analysisAdd BLAST20
Transmembranei324 – 347HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 287Proton_antipo_MInterPro annotationAdd BLAST264
Domaini290 – 343NADH_dehy_S2_CInterPro annotationAdd BLAST54

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR010933. NADH_DH_su2_C.
IPR003917. NADH_UbQ_OxRdtase_chain2.
IPR001750. ND/Mrp_mem.
PfamiView protein in Pfam
PF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PRINTSiPR01436. NADHDHGNASE2.

Sequencei

Sequence statusi: Complete.

G9L9I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLVLSILI LSLGLGTTIT FMGSHWLLIW MGLEINTMAI IPLMIHQQHP
60 70 80 90 100
RAVEATTKYF LTQATASALL LFAGTTNAWT TGQWNITDML SPTSATLITL
110 120 130 140 150
ALALKIGLAP MHFWLPEVLQ GLSLTTGLIL STWQKLAPFA ILLQLYPLLN
160 170 180 190 200
PNILMTLGVA SIVIGGWSGL NQTQLRKILA YSSIAHLGWM ITILHFAPNL
210 220 230 240 250
ALLNLALYII MTTSMFLLFN TLNSTKINSI SVSATKAPLL SIMSLVTLLS
260 270 280 290 300
LGGLPPLSGF MPKWLILQEM TKQDLLIPAT IMALATLLSL FFYLRLCYAM
310 320 330 340
TLTISPTPIF FMSSWRTKTT QTNILLTITT SLSILLLPLT PTLLTLFT
Length:348
Mass (Da):38,214
Last modified:February 22, 2012 - v1
Checksum:iDA5F6B06F6AA415D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ034406 Genomic DNA. Translation: AET87630.1.
RefSeqiYP_004935519.1. NC_016429.1.

Genome annotation databases

GeneIDi11452179.

Similar proteinsi

Entry informationi

Entry nameiG9L9I0_LEUER
AccessioniPrimary (citable) accession number: G9L9I0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 7, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)