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G9HS63

- G9HS63_9HIV1

UniProt

G9HS63 - G9HS63_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HPOX-ray1.69P166-184[»]
    4HPYX-ray1.50P166-184[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    G9HS63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVKETQMSW PNLWRWGTLI LGLVIMCSAS DNLWVTVYYG VPVWRDADTT    50
    LFCASDAKAH ETEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNKMV 100
    EQMHEDVISL WDQSLQPCVK LTPLCVTLHC TDNVKVINET NTTSSLGLVG 150
    NITNEVSNCT FNMTTELRDK KQKVHALFYK LDIVKINENN KNSSIKNNNN 200
    NSSENSTTSN SSEYSEYMLI NCNTSVIKQA CPKISFDPIP IHYCTPAGYA 250
    ILKCNEKNFN GTGPCKNVSS VQCTHGIKPV VSTQLLLNGS LAEEEIIIRS 300
    ENLTDNTKNI IVHLNRSVAI NCTRPFNNTR QSIHIGPGQA FYKTGDIIGD 350
    IRQAFCEING TAWNETLKWV SGKLREHFKN KTIIFNSSSG GDPEITMHHF 400
    NCGGEFFYCN TTKLFNSSWE ENNNSTWDNE NNNSTRDNGN ITIPCRIKQI 450
    VNMWQGTGQA MYAPPIRGAI NCVSNITGIL LTRDGGRDNG TNNSTETFRP 500
    GGGNIKDNWR SELYKYKVVQ IEPLGLAPTR AKRRVVDREK RAVGIGAMIF 550
    GFLGAAGSTM GAASITLTVQ ARQLLSGIVQ QQSNLLRAIE AQHHLLQLTV 600
    WGIKQLQARV LAVERYLKDQ TLLGLWGCSG KIICTTAVPW NSTWSNKSYD 650
    EIWDNMTWIQ WEREISNYTN QIYGLLTESQ NQQDKNEQDL LQLDKWASLW 700
    NWFSITNWLW YIKIFIMIVG GLIGLRIVFT VLSIVNRVRQ GYSPLSFQTL 750
    THHQREPDRP ERIEEGGGEQ DRDRSVRLVS GFLALAWDDL RSLCLFSYHH 800
    LRDFILIAAR TVELLGLRRG WEALKYLGNL LLYWSQELKI SAISLLDATA 850
    ITVAGWTDRI IEVVQGAGRA ILHIPRRIRQ GLERALL 887
    Length:887
    Mass (Da):100,425
    Last modified:February 22, 2012 - v1
    Checksum:i55A617B00D028F0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JN388147 Genomic DNA. Translation: AET80836.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JN388147 Genomic DNA. Translation: AET80836.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HPO X-ray 1.69 P 166-184 [» ]
    4HPY X-ray 1.50 P 166-184 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AE-Env_CR11_Jan10RImported.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 166-184.

    Entry informationi

    Entry nameiG9HS63_9HIV1
    AccessioniPrimary (citable) accession number: G9HS63
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3