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G9HS63 (G9HS63_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein gp160 RuleBase RU004292
Gene names
Name:env EMBL AET80836.1
OrganismHuman immunodeficiency virus 1 EMBL AET80836.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length887 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity.

Ontologies

Keywords
   Biological processApoptosis SAAS SAAS000328
Fusion of virus membrane with host membrane SAAS SAAS000328
Host-virus interaction
Viral attachment to host cell SAAS SAAS000328 RuleBase RU004292
Viral immunoevasion RuleBase RU004292
Viral penetration into host cytoplasm
Virus entry into host cell
   Cellular componentHost cell membrane SAAS SAAS000328
Host endosome SAAS SAAS000328
Host membrane
Membrane
Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AET80836.1
Virion
   DiseaseAIDS RuleBase RU003294
   DomainTransmembrane
Transmembrane helix SAAS SAAS000328
   PTMCleavage on pair of basic residues RuleBase RU004292
Disulfide bond SAAS SAAS000328
   Technical term3D-structure PDB 4HPO PDB 4HPY
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

evasion or tolerance by virus of host immune response

Inferred from electronic annotation. Source: UniProtKB-KW

membrane fusion involved in viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
G9HS63 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: 55A617B00D028F0E

FASTA887100,425
        10         20         30         40         50         60 
MRVKETQMSW PNLWRWGTLI LGLVIMCSAS DNLWVTVYYG VPVWRDADTT LFCASDAKAH 

        70         80         90        100        110        120 
ETEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNKMV EQMHEDVISL WDQSLQPCVK 

       130        140        150        160        170        180 
LTPLCVTLHC TDNVKVINET NTTSSLGLVG NITNEVSNCT FNMTTELRDK KQKVHALFYK 

       190        200        210        220        230        240 
LDIVKINENN KNSSIKNNNN NSSENSTTSN SSEYSEYMLI NCNTSVIKQA CPKISFDPIP 

       250        260        270        280        290        300 
IHYCTPAGYA ILKCNEKNFN GTGPCKNVSS VQCTHGIKPV VSTQLLLNGS LAEEEIIIRS 

       310        320        330        340        350        360 
ENLTDNTKNI IVHLNRSVAI NCTRPFNNTR QSIHIGPGQA FYKTGDIIGD IRQAFCEING 

       370        380        390        400        410        420 
TAWNETLKWV SGKLREHFKN KTIIFNSSSG GDPEITMHHF NCGGEFFYCN TTKLFNSSWE 

       430        440        450        460        470        480 
ENNNSTWDNE NNNSTRDNGN ITIPCRIKQI VNMWQGTGQA MYAPPIRGAI NCVSNITGIL 

       490        500        510        520        530        540 
LTRDGGRDNG TNNSTETFRP GGGNIKDNWR SELYKYKVVQ IEPLGLAPTR AKRRVVDREK 

       550        560        570        580        590        600 
RAVGIGAMIF GFLGAAGSTM GAASITLTVQ ARQLLSGIVQ QQSNLLRAIE AQHHLLQLTV 

       610        620        630        640        650        660 
WGIKQLQARV LAVERYLKDQ TLLGLWGCSG KIICTTAVPW NSTWSNKSYD EIWDNMTWIQ 

       670        680        690        700        710        720 
WEREISNYTN QIYGLLTESQ NQQDKNEQDL LQLDKWASLW NWFSITNWLW YIKIFIMIVG 

       730        740        750        760        770        780 
GLIGLRIVFT VLSIVNRVRQ GYSPLSFQTL THHQREPDRP ERIEEGGGEQ DRDRSVRLVS 

       790        800        810        820        830        840 
GFLALAWDDL RSLCLFSYHH LRDFILIAAR TVELLGLRRG WEALKYLGNL LLYWSQELKI 

       850        860        870        880 
SAISLLDATA ITVAGWTDRI IEVVQGAGRA ILHIPRRIRQ GLERALL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JN388147 Genomic DNA. Translation: AET80836.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPOX-ray1.69P166-184[»]
4HPYX-ray1.50P166-184[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 2 hits.
ProtoNetSearch...

Entry information

Entry nameG9HS63_9HIV1
AccessionPrimary (citable) accession number: G9HS63
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)