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G9HS63

- G9HS63_9HIV1

UniProt

G9HS63 - G9HS63_9HIV1

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Protein
Envelope glycoprotein gp160
Gene
env
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity.UniRule annotationSAAS annotations
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.SAAS annotations

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotations, Fusion of virus membrane with host membraneSAAS annotations, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotations, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host endosomeSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationsImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPOX-ray1.69P166-184[»]
4HPYX-ray1.50P166-184[»]

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

G9HS63-1 [UniParc]FASTAAdd to Basket

« Hide

MRVKETQMSW PNLWRWGTLI LGLVIMCSAS DNLWVTVYYG VPVWRDADTT    50
LFCASDAKAH ETEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNKMV 100
EQMHEDVISL WDQSLQPCVK LTPLCVTLHC TDNVKVINET NTTSSLGLVG 150
NITNEVSNCT FNMTTELRDK KQKVHALFYK LDIVKINENN KNSSIKNNNN 200
NSSENSTTSN SSEYSEYMLI NCNTSVIKQA CPKISFDPIP IHYCTPAGYA 250
ILKCNEKNFN GTGPCKNVSS VQCTHGIKPV VSTQLLLNGS LAEEEIIIRS 300
ENLTDNTKNI IVHLNRSVAI NCTRPFNNTR QSIHIGPGQA FYKTGDIIGD 350
IRQAFCEING TAWNETLKWV SGKLREHFKN KTIIFNSSSG GDPEITMHHF 400
NCGGEFFYCN TTKLFNSSWE ENNNSTWDNE NNNSTRDNGN ITIPCRIKQI 450
VNMWQGTGQA MYAPPIRGAI NCVSNITGIL LTRDGGRDNG TNNSTETFRP 500
GGGNIKDNWR SELYKYKVVQ IEPLGLAPTR AKRRVVDREK RAVGIGAMIF 550
GFLGAAGSTM GAASITLTVQ ARQLLSGIVQ QQSNLLRAIE AQHHLLQLTV 600
WGIKQLQARV LAVERYLKDQ TLLGLWGCSG KIICTTAVPW NSTWSNKSYD 650
EIWDNMTWIQ WEREISNYTN QIYGLLTESQ NQQDKNEQDL LQLDKWASLW 700
NWFSITNWLW YIKIFIMIVG GLIGLRIVFT VLSIVNRVRQ GYSPLSFQTL 750
THHQREPDRP ERIEEGGGEQ DRDRSVRLVS GFLALAWDDL RSLCLFSYHH 800
LRDFILIAAR TVELLGLRRG WEALKYLGNL LLYWSQELKI SAISLLDATA 850
ITVAGWTDRI IEVVQGAGRA ILHIPRRIRQ GLERALL 887
Length:887
Mass (Da):100,425
Last modified:February 22, 2012 - v1
Checksum:i55A617B00D028F0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JN388147 Genomic DNA. Translation: AET80836.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JN388147 Genomic DNA. Translation: AET80836.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HPO X-ray 1.69 P 166-184 [» ]
4HPY X-ray 1.50 P 166-184 [» ]
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AE-Env_CR11_Jan10RImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 166-184.

Entry informationi

Entry nameiG9HS63_9HIV1
AccessioniPrimary (citable) accession number: G9HS63
Entry historyi
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi