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G9AWR2 (G9AWR2_PANAN) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CCF08004.1
Synonyms:ddl HAMAP-Rule MF_00047
ORF Names:PANA5342_0611 EMBL CCF08004.1
OrganismPantoea ananatis LMG 5342 [Complete proteome] EMBL CCF08004.1
Taxonomic identifier1123863 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain145 – 348204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding175 – 23056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3171Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G9AWR2 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: FE978840447CC93C

FASTA36539,635
        10         20         30         40         50         60 
MKKQRVGIVF GGKSSEHEVS LQSAKNIVDA IDKTRFEVVL LGIDKQGQWH LNDASNFLLN 

        70         80         90        100        110        120 
AENPSLIALN RTAKQVALIP GEPQNQIIDR KDAHPLSQLD VIFPVVHGTQ GEDGSLQGLL 

       130        140        150        160        170        180 
RMASLPFVGS DVLGSAVSMD KDVTKRLLRD AGLKVAPWLS VTQAQMNKLD IEAVIARFGL 

       190        200        210        220        230        240 
PLFIKPANQG SSVGVSKVTT AAAFRAALEL AFRFDNKVLI EKGIKGREIE CAVLGNDYPE 

       250        260        270        280        290        300 
ASPCGEVVVS DAFYSYDTKY ISETGAHTVI PADIPAAVDE AIREVALTAF TALSCFGLAR 

       310        320        330        340        350        360 
VDVFYTEDGE IIVNEVNTLP GFTNISMYPK LWQAAGLSYQ DLITRLIELA LERHQQNASL 


KTSVN 

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References

[1]"Complete Genome Sequence of Clinical Isolate Pantoea ananatis LMG 5342."
De Maayer P., Chan W.Y., Rezzonico F., Buhlmann A., Venter S.N., Blom J., Goesmann A., Frey J.E., Smits T.H., Duffy B., Coutinho T.A.
J. Bacteriol. 194:1615-1616(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LMG 5342 EMBL CCF08004.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE617160 Genomic DNA. Translation: CCF08004.1.
RefSeqYP_005194041.1. NC_016816.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCF08004; CCF08004; PANA5342_0611.
GeneID11795192.
KEGGplf:PANA5342_0611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycPANA1123863:GJWO-630-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG9AWR2_PANAN
AccessionPrimary (citable) accession number: G9AWR2
Entry history
Integrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)