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Protein

Thymidine kinase

Gene

tdk

Organism
Rhizobium fredii (strain HH103) (Sinorhizobium fredii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SFHH103_02234Imported
OrganismiRhizobium fredii (strain HH103) (Sinorhizobium fredii)Imported
Taxonomic identifieri1117943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000007735 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1117943.SFHH103_02234

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

G9A8Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFSYAT MNAGKSTLLL QAAYNYQERG MRVVMLIAAF DDRAGTGRIA
60 70 80 90 100
SRIGLKSDGI PFHGGDDLYG LIERLNDDGS GEIACVFVDE AQFLDEDQVW
110 120 130 140 150
QLARVADRLG IPVMAYGLRT DFQGKLFPGS MALLALADEL REVRTICHCG
160 170 180 190
RKATMVVRLD GDGNVVREGA QVDVGGNEKY VSYCRRHWED RMRDG
Length:195
Mass (Da):21,666
Last modified:February 22, 2012 - v1
Checksum:i4830F7F2C91C8F40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE616890 Genomic DNA Translation: CCE96729.1
RefSeqiWP_014329169.1, NC_016812.1

Genome annotation databases

GeneIDi34334310
KEGGisfh:SFHH103_02234
PATRICifig|380.5.peg.2374

Similar proteinsi

Entry informationi

Entry nameiG9A8Z9_RHIFH
AccessioniPrimary (citable) accession number: G9A8Z9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health